Protonation dynamics of the alpha-toxin ion channel from spectral analysis of pH-dependent current fluctuations

Coupling of Phosphorylation to Electron and Hydrogen Transfer by a Chemi-Osmotic type of Mechanism

1961 • 4,416 citations

Single-channel currents recorded from membrane of denervated frog muscle fibres

1976 • 2,456 citations

Formation of Bimolecular Membranes from Lipid Monolayers and a Study of Their Electrical Properties

1972 • 1,746 citations

Alpha-toxin of Staphylococcus aureus

1991 • 758 citations

Interpretation of protein titration curves. Application to lysozyme

1972 • 482 citations

Calculation of electrostatic potentials in an enzyme active site

1987 • 449 citations

On the mechanism of membrane damage by Staphylococcus aureus alpha-toxin.

1981 • 369 citations

Ionic channels formed byStaphylococcus aureus alpha-toxin: Voltage-dependent inhibition by divalent and trivalent cations

1986 • 349 citations

On the functional proton current pathway of electron transport phosphorylation

1979 • 340 citations

Proton migration along the membrane surface and retarded surface to bulk transfer

1994 • 334 citations

Selectivity Changes in Site-Directed Mutants of the VDAC Ion Channel: Structural Implications

1990 • 269 citations

Subunit stoichiometry of staphylococcal alpha-hemolysin in crystals and on membranes: a heptameric transmembrane pore.

1994 • 238 citations

Anionic lipid headgroups as a proton-conducting pathway along the surface of membranes: a hypothesis.

1983 • 223 citations

Direct measurement of proton transfer rates to a group controlling the dihydropyridine-sensitive Ca2+ channel

1987 • 201 citations

Current noise reveals protonation kinetics and number of ionizable sites in an open protein ion channel

1993 • 192 citations

A simple method for the determination of the pore radius of ion channels in planar lipid bilayer membranes

1992 • 182 citations

Staphylococcal alpha-toxin: oligomerization of hydrophilic monomers to form amphiphilic hexamers induced through contact with deoxycholate detergent micelles.

1981 • 177 citations

Discrete Conductance Fluctuations in Lipid Bilayer Protein Membranes

1969 • 173 citations

Primary sequence of the alpha-toxin gene from Staphylococcus aureus wood 46

1984 • 168 citations

Secondary structure and assembly mechanism of an oligomeric channel protein

1985 • 160 citations

Two Identical Noninteracting Sites in an Ion Channel Revealed by Proton Transfer

1994 • 160 citations

Proton flux mechanisms in model and biological membranes

1989 • 156 citations

Spectroscopic and ionization properties of N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)-labeledlipidsinmodelmembranes

1988 • 155 citations

Open channel noise. I. Noise in acetylcholine receptor currents suggests conformational fluctuations

1985 • 147 citations

Surface-bound optical probes monitor protein translocation and surface potential changes during the bacteriorhodopsin photocycle.

1992 • 143 citations

Correlation between toxin binding and hemolytic activity in membrane damage by staphylococcal alpha-toxin

1984 • 112 citations

Acid-induced unfolding and refolding transitions of cytochrome c: A three-state mechanism in water and deuterium oxide

1993 • 112 citations

Molecular design of PhoE porin and its functional consequences

1989 • 108 citations

Staphylococcal alpha toxin — recent advances

1988 • 88 citations

Functional expression of the alpha-hemolysin of Staphylococcus aureus in intact Escherichia coli and in cell lysates. Deletion of five C-terminal amino acids selectively impairs hemolytic activity.

1992 • 83 citations

How do protons cross the membrane-solution interface? Kinetic studies on bilayer membranes exposed to the protonophore S-13 (5-chloro-3-tert-butyl-2′-chloro-4′ nitrosalicylanilide)

1987 • 81 citations

Conformational changes associated with ion permeation in L-type calcium channels

1988 • 81 citations

A pore-forming protein with a metal-actuated switch

1994 • 81 citations

On the Mechanism of Action of Ribonuclease T₁

1971 • 59 citations

Open channel noise. V. Fluctuating barriers to ion entry in gramicidin A channels

1990 • 57 citations

Study of membrane permeability changes by fluctuation analysis

1977 • 53 citations

A Pore-forming protein with a protease-activated trigger

1994 • 51 citations

Quantitation of physical-chemical properties of the aqueous phase inside the phoE ionic channel

1992 • 47 citations

Staphylococcus aureus alpha-toxin. Production of functionally intact, site-specifically modifiable protein by introduction of cysteine at positions 69, 130, and 186

1993 • 44 citations

Proton diffusion along the membrane surface of thylakoids is not enhanced over that in bulk water

1989 • 41 citations

Dynamic studies of proton diffusion in mesoscopic heterogeneous matrix

1992 • 37 citations

Assembly of the alpha-toxin-hexamer of Staphylococcus aureus in the liposome membrane.

1987 • 36 citations

Triggeps and switches in a self‐assembling pore‐forming portein

1994 • 34 citations

Fluctuation of No and K Currents in Excitable Membranes

1982 • 31 citations

Modification of lysine residues ofStaphylococcus aureus α-toxin: Effects on its channel-forming properties

1991 • 31 citations

The projection structure of α-toxin from Staphylococcus aureus in human platelet membranes as analyzed by electron microscopy and image processing

1988 • 27 citations

Hofmeister effect in ion transport: reversible binding of halide anions to the roflamycoin channel

1994 • 26 citations

On-line computer-assisted analysis of 220 MHz NMR data of protein imidazole resonances

1970 • 26 citations

Reaction of bulk protons with a mitochondrial inner membrane preparation: Time-resolved measurements and their analysis

1993 • 26 citations