Phosphorylation of Claudin-3 at Threonine 192 by cAMP-dependent Protein Kinase Regulates Tight Junction Barrier Function in Ovarian Cancer Cells

Multifunctional strands in tight junctions

2001 • 2,392 citations

The tight junction: a multifunctional complex

2004 • 1,360 citations

Tight junction proteins

2002 • 1,091 citations

Adv. Drug Delivery Rev.

1997 • 881 citations

Signalling to and from tight junctions

2003 • 863 citations

Localized Effects of cAMP Mediated by Distinct Routes of Protein Kinase A

2004 • 745 citations

Large-scale serial analysis of gene expression reveals genes differentially expressed in ovarian cancer.

2000 • 486 citations

Selection of Potential Markers for Epithelial Ovarian Cancer with Gene Expression Arrays and Recursive Descent Partition Analysis

2004 • 442 citations

Molecular Physiology and Pathophysiology of Tight Junctions I. Tight junction structure and function: lessons from mutant animals and proteins

2000 • 439 citations

Tight junction proteins claudin-3 and claudin-4 are frequently overexpressed in ovarian cancer but not in ovarian cystadenomas.

2003 • 338 citations

Gene expression profiles in primary ovarian serous papillary tumors and normal ovarian epithelium: Identification of candidate molecular markers for ovarian cancer diagnosis and therapy

2004 • 304 citations

Protein kinase inhibitors prevent junction dissociation induced by low extracellular calcium in MDCK epithelial cells

1992 • 280 citations

Disease-causing mutant WNK4 increases paracellular chloride permeability and phosphorylates claudins

2004 • 260 citations

Protein phosphatase 2A associates with and regulates atypical PKC and the epithelial tight junction complex

2002 • 254 citations

Differential Gene Expression in Ovarian Carcinoma

2004 • 230 citations

Overexpression of the Cell Adhesion Molecules DDR1, Claudin 3, and Ep-CAM in Metaplastic Ovarian Epithelium and Ovarian Cancer

2004 • 207 citations

Cyclic AMP induces phosphorylation of claudin-5 immunoprecipitates and expression of claudin-5 gene in blood–brain-barrier endothelial cells via protein kinase A-dependent and -independent pathways

2003 • 191 citations

Tyrosine phosphorylation of occludin attenuates its interactions with ZO-1, ZO-2, and ZO-3

2003 • 182 citations

The Organization of Tight Junctions in Epithelia: Implications for Mammary Gland Biology and Breast Tumorigenesis

2003 • 143 citations

Thr203 of claudin-1, a putative phosphorylation site for MAP kinase, is required to promote the barrier function of tight junctions

2004 • 135 citations

Thr207 of claudin-5 is involved in size-selective loosening of the endothelial barrier by cyclic AMP

2004 • 124 citations

Activation of ERK1/2 MAP kinase pathway induces tight junction disruption in human corneal epithelial cells

2003 • 117 citations

Tight junction-related structures in the absence of a lumen: Occludin, claudins and tight junction plaque proteins in densely packed cell formations of stratified epithelia and squamous cell carcinomas

2003 • 109 citations

Tight junctions and their role in cancer metastasis.

2001 • 99 citations

Role of VASP in reestablishment of epithelial tight junction assembly after Ca²⁺ switch

2002 • 94 citations

Modification of tight junction function by protein kinase C isoforms

2000 • 89 citations

Regulation of epithelial transport and barrier function by distinct protein kinase C isoforms

2001 • 86 citations

Molecular Physiology and Pathophysiology of Tight Junctions III. Tight junction regulation by intracellular messengers: differences in response within and between epithelia

2000 • 75 citations

Tight-junction protein zonula occludens 2 is a target of phosphorylation by protein kinase C

2001 • 73 citations

Increased expression of the RIα subunit of the cAMP-dependent protein kinase A is associated with advanced stage ovarian cancer

1999 • 61 citations

Dissecting the Circuitry of Protein Kinase A and cAMP Signaling in Cancer Genesis

2002 • 54 citations

Disruption of epithelial tight junctions is prevented by cyclic nucleotide-dependent protein kinase inhibitors

2000 • 53 citations

Tight-junction protein zonula occludens 2 is a target of phosphorylation by protein kinase C

2001 • 51 citations

PKC signalling regulates tight junction membrane assembly in the pre-implantation mouse embryo

2004 • 48 citations

Protein kinase A-Iα subunit-directed antisense inhibition of ovarian cancer cell growth: crosstalk with tyrosine kinase signaling pathway

1999 • 34 citations

Organotypic culture of human ovarian surface epithelial cells: A potential model for ovarian carcinogenesis

1998 • 26 citations

Cyclic AMP‐dependent protein kinase A negatively modulates adherens junction integrity and differentiation of intestinal epithelial cells

2004 • 18 citations