Disease-causing mutant WNK4 increases paracellular chloride permeability and phosphorylates claudins

Human Hypertension Caused by Mutations in WNK Kinases

2001 • 1,427 citations

Paracellin-1, a Renal Tight Junction Protein Required for Paracellular Mg ²⁺ Resorption

1999 • 1,107 citations

Direct Binding of Three Tight Junction-Associated Maguks, Zo-1, Zo-2, and Zo-3, with the Cooh Termini of Claudins

1999 • 1,094 citations

Claudin-2 expression induces cation-selective channels in tight junctions of epithelial cells

2002 • 769 citations

Conversion of Zonulae Occludentes from Tight to Leaky Strand Type by Introducing Claudin-2 into Madin-Darby Canine Kidney I Cells

2001 • 704 citations

Regulated expression of claudin-4 decreases paracellular conductance through a selective decrease in sodium permeability

2001 • 588 citations

Claudins create charge-selective channels in the paracellular pathway between epithelial cells

2002 • 530 citations

WNK1, a Novel Mammalian Serine/Threonine Protein Kinase Lacking the Catalytic Lysine in Subdomain II

2000 • 503 citations

WNK kinases regulate thiazide-sensitive Na-Cl cotransport

2003 • 428 citations

Molecular pathogenesis of inherited hypertension with hyperkalemia: The Na–Cl cotransporter is inhibited by wild-type but not mutant WNK4

2003 • 404 citations

Claudin extracellular domains determine paracellular charge selectivity and resistance but not tight junction fibril architecture

2003 • 377 citations

WNK4 regulates the balance between renal NaCl reabsorption and K+ secretion

2003 • 366 citations

Claudin-8 Expression in Madin-Darby Canine Kidney Cells Augments the Paracellular Barrier to Cation Permeation

2003 • 273 citations

Mineralocorticoid-resistant renal hyperkalemia without salt wasting (type II pseudohypoaldosteronism): Role of increased renal chloride reabsorption

1981 • 246 citations

Localization of the thiazide sensitive Na-Cl cotransporter, rTSC1, in the rat kidney

1996 • 185 citations

Localization of the ROMK protein on apical membranes of rat kidney nephron segments

1997 • 184 citations

Regulation of WNK1 by an Autoinhibitory Domain and Autophosphorylation

2002 • 163 citations

Chloride transport by the cortical and outer medullary collecting duct

1987 • 103 citations

Familial Hyperpotassemia and Hypertension Accompanied by Normal Plasma Aldosterone Levels

1978 • 74 citations

Interleukin-2 Receptor β Subunit-dependent and -independent Regulation of Intestinal Epithelial Tight Junctions

2001 • 59 citations