Insulin-induced surface redistribution regulates internalization of the insulin receptor and requires its autophosphorylation.

Insulin Stimulates the Phosphorylation of the 95,000-Dalton Subunit of Its Own Receptor

1982 • 1,138 citations

Replacement of insulin receptor tyrosine residues 1162 and 1163 compromises insulin-stimulated kinase activity and uptake of 2-deoxyglucose

1986 • 1,100 citations

NPXY, a sequence often found in cytoplasmic tails, is required for coated pit-mediated internalization of the low density lipoprotein receptor.

1990 • 944 citations

After Insulin Binds

1987 • 687 citations

The insulin receptor and the molecular mechanism of insulin action.

1988 • 426 citations

A mutant insulin receptor with defective tyrosine kinase displays no biologic activity and does not undergo endocytosis.

1987 • 403 citations

Replacement of lysine residue 1030 in the putative ATP-binding region of the insulin receptor abolishes insulin- and antibody-stimulated glucose uptake and receptor kinase activity.

1987 • 399 citations

The protein-tyrosine kinase activity of the insulin receptor is necessary for insulin-mediated receptor down-regulation.

1987 • 179 citations

125I-insulin binding to cultured human lymphocytes. Initial localization and fate of hormone determined by quantitative electron microscopic autoradiography.

1978 • 171 citations

Co-localization of 125I-epidermal growth factor and ferritin-low density lipoprotein in coated pits: a quantitative electron microscopic study in normal and mutant human fibroblasts.

1982 • 171 citations

Receptor-mediated internalization of insulin requires a 12-amino acid sequence in the juxtamembrane region of the insulin receptor beta-subunit.

1990 • 130 citations

Expression of a functional human insulin receptor from a cloned cDNA in Chinese hamster ovary cells.

1985 • 128 citations

Defective internalization of insulin and its receptor in cells expressing mutated insulin receptors lacking kinase activity.

1987 • 97 citations

A domain of the insulin receptor required for endocytosis in rat fibroblasts.

1990 • 97 citations

Receptor-mediated endocytosis of insulin: role of microvilli, coated pits, and coated vesicles.

1982 • 97 citations

Surface redistribution of 125I-insulin in cultured human lymphocytes.

1981 • 79 citations

Monoclonal antibodies to the insulin receptor mimic metabolic effects of insulin but do not stimulate receptor autophosphorylation in transfected NIH 3T3 fibroblasts.

1989 • 63 citations

The cell biology of the insulin receptor

1989 • 50 citations

Tyrosine phosphorylation of the insulin receptor is not required for receptor internalization: studies in 2,4-dinitrophenol-treated cells.

1989 • 49 citations

Receptor cross-linking restores an insulin metabolic effect altered by mutation on tyrosine 1162 and tyrosine 1163

1989 • 49 citations

Endocytosis, Recycling, and Degradation of the Insulin Receptor

1989 • 36 citations

Insulin receptor function in fibroblasts from patients with leprechaunism. Differential alterations in binding, autophosphorylation, kinase activity, and receptor-mediated internalization.

1988 • 34 citations

Redistribution of 125I-Insulin on the Surface of Rat Hepatocytes as a Function of Dissociation Time

1985 • 33 citations

Mutation of Tyrosine Residues 1162 and 1163 of the Insulin Receptor Affects Hormone and Receptor Internalization

1990 • 31 citations

The Relationship of Ligand Receptor Mobility to Internalization of Polypeptide Hormones and Growth Factors*

1991 • 13 citations