Advances in the Treatment of Alzheimer’s Disease: Benefits of Dual Cholinesterase Inhibition

The Cholinergic Hypothesis of Geriatric Memory Dysfunction

1982 • 5,422 citations

Alzheimer's Disease and Senile Dementia: Loss of Neurons in the Basal Forebrain

1982 • 3,563 citations

Practice parameter: Management of dementia (an evidence-based review) [RETIRED]

2001 • 1,742 citations

Efficacy of rivastigmine in dementia with Lewy bodies: a randomised, double-blind, placebo-controlled international study

2000 • 1,110 citations

Mental and Behavioral Disturbances in Dementia: Findings From the Cache County Study on Memory in Aging

2000 • 1,110 citations

Acetylcholinesterase Accelerates Assembly of Amyloid-β-Peptides into Alzheimer's Fibrils: Possible Role of the Peripheral Site of the Enzyme

1996 • 1,058 citations

Acetylcholinesterase: enzyme structure, reaction dynamics, and virtual transition states

1987 • 1,044 citations

The Cholinesterases: From Genes to Proteins

1994 • 650 citations

Neurotransmitter-related enzymes in senile dementia of the alzheimer type

1979 • 638 citations

CHANGES IN BRAIN CHOLINESTERASES IN SENILE DEMENTIA OF ALZHEIMER TYPE

1978 • 535 citations

Consensus Statement on the Upcoming Crisis in Geriatric Mental Health

1999 • 513 citations

A randomized trial evaluating the efficacy and safety of ENA 713 (rivastigmine tartrate), a new acetylcholinesterase inhibitor, in patients with mild to moderately severe Alzheimer's disease

1998 • 473 citations

The cholinergic system in Alzheimer's disease

1997 • 399 citations

Cholinesterase Inhibitors: A New Class of Psychotropic Compounds

2000 • 384 citations

Is senile dementia "age-related" or "ageing-related"? —evidence from meta-analysis of dementia prevalence in the oldest old

1995 • 353 citations

Abundant Tissue Butyrylcholinesterase and Its Possible Function in the Acetylcholinesterase Knockout Mouse

2000 • 347 citations

A 52-Week Study of the Efficacy of Rivastigmine in Patients with Mild to Moderately Severe Alzheimer’s Disease

2000 • 324 citations

Changes in acetylcholinesterase and butyrylcholinesterase in Alzheimer's disease resemble embryonic development—A study of molecular forms

1992 • 307 citations

Butyrylcholinesterase in the life cycle of amyloid plaques

1997 • 294 citations

Selectivity of Cholinesterase Inhibition

1999 • 271 citations

Postnatal developmental delay and supersensitivity to organophosphate in gene-targeted mice lacking acetylcholinesterase.

2000 • 253 citations

Butyrylcholinesterase reactivity differentiates the amyloid plaques of aging from those of dementia

1994 • 246 citations

Clinical and cost-effectiveness of donepezil, rivastigmine and galantamine for Alzheimer's disease: a rapid and systematic review

2001 • 245 citations

Neuroglial cholinesterases in the normal brain and in Alzheimer's disease: Relationship to plaques, tangles, and patterns of selective vulnerability

1993 • 218 citations

Progressive brain atrophy on serial MRI in dementia with Lewy bodies, AD, and vascular dementia

2001 • 214 citations

Ageing: the cholinergic hypothesis of cognitive decline

1995 • 208 citations

Synthesis of Novel Phenserine-Based-Selective Inhibitors of Butyrylcholinesterase for Alzheimer's Disease

1999 • 206 citations

Synergy Between the Genes for Butyrylcholinesterase K Variant and Apolipoprotein E4 in Late-Onset Confirmed Alzheimer's Disease

1997 • 201 citations

Cholinesterases and the Pathology of Alzheimer Disease

1995 • 188 citations

Molecular Forms of Acetylcholinesterase and Butyrylcholinesterase in the Aged Human Central Nervous System

1986 • 184 citations

An efficacy and safety analysis of Exelon^® in Alzheimer’s disease patients with concurrent vascular risk factors

2000 • 158 citations

Cholinesterases within neurofibrillary tangles related to age and Alzheimer's disease

1987 • 126 citations

Functional Disability in Alzheimer's Disease

1997 • 124 citations

Long-term effects of rivastigmine in moderately severe Alzheimer's disease

2002 • 108 citations

From Molecular Structure to Alzheimer Therapy.

1997 • 96 citations

Pathological Proteins in Senile Plaques.

1994 • 92 citations

Symptoms, Vascular Risk Factors and Blood-Brain Barrier Function in Relation to CT White-Matter Changes in Dementia

2000 • 91 citations

Molecular forms of acetylcholinesterase in subcortical areas of normal and Alzheimer disease brain

1990 • 85 citations

Methyl Analogues of the Experimental Alzheimer Drug Phenserine: Synthesis and Structure/Activity Relationships for Acetyl- and Butyrylcholinesterase Inhibitory Action

2001 • 79 citations

Further evidence for a synergistic association between APOE ?4 and BCHE -K in confirmed Alzheimer's disease

1999 • 72 citations

The experimental Alzheimer drug phenserine: preclinical pharmacokinetics and pharmacodynamics

2000 • 68 citations

Chapter 33 The cholinergic receptor system of the human brain: neurochemical and pharmacological aspects in aging and Alzheimer

1989 • 64 citations

Analysis of association between Alzheimer disease and the K variant of butyrylcholinesterase (BCHE-K)

1999 • 38 citations

The butyrylcholinesterase K variant is a protective factor for sporadic Alzheimer's disease in women

2000 • 36 citations

Occurrence of acetylcholinesterase activity closely associated with amyloid ?/A4 protein is not correlated with acetylcholinesterase-positive fiber density in amygdala of Alzheimer's disease

1992 • 15 citations

The effects of rivastigmine on behavioral symptoms in severe ad patients in a nursing home setting

2000 • 5 citations

Deleted Work

1955 • 0 citations