Further evidence for a synergistic association between APOE ?4 and BCHE -K in confirmed Alzheimer's disease

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.

1993 • 4,145 citations

CHANGES IN BRAIN CHOLINESTERASES IN SENILE DEMENTIA OF ALZHEIMER TYPE

1978 • 535 citations

The use of a genetic map of biallelic markers in linkage studies

1997 • 499 citations

DNA sequence diversity in a 9.7-kb region of the human lipoprotein lipase gene

1998 • 485 citations

Comparative Alterations of Nicotinic and Muscarinic Binding Sites in Alzheimer's and Parkinson's Diseases

1992 • 324 citations

Butyrylcholinesterase in the life cycle of amyloid plaques

1997 • 294 citations

Mutagenically separated PCR (MS-PCR): a highly specific one step procedure for easy mutation detection

1993 • 251 citations

Nucleus basalis neuronal loss, neuritic plaques and choline acetyltransferase activity in advanced Alzheimer's disease

1986 • 210 citations

DNA mutation associated with the human butyrylcholinesterase K-variant and its linkage to the atypical variant mutation and other polymorphic sites.

1992 • 208 citations

Synergy Between the Genes for Butyrylcholinesterase K Variant and Apolipoprotein E4 in Late-Onset Confirmed Alzheimer's Disease

1997 • 201 citations

Structure of the gene for human butyrylcholinesterase. Evidence for a single copy

1990 • 161 citations

Distribution of butyrylcholinesterase in the human amygdala and hippocampal formation

1998 • 147 citations

Structure and Function of Cholinesterases and Related Proteins

1998 • 128 citations

ENZYME HISTOCHEMICAL STUDIES OF SENILE PLAQUES

1965 • 127 citations

E1k, another quantitative variant at cholinesterase locus 1.

1978 • 117 citations

The cloned butyrylcholinesterase (BCHE) gene maps to a single chromosome site, 3q26

1991 • 111 citations

Confidence intervals for the odds ratio in case-control studies: The state of the art

1979 • 105 citations

Characterization of 12 silent alleles of the human butyrylcholinesterase (BCHE) gene.

1996 • 102 citations

Electron microscopic localization of cholinesterase activity in Alzheimer brain tissue

1991 • 100 citations

No association between the K variant of the butyrylcholinesterase gene and pathologically confirmed Alzheimer's disease

1998 • 63 citations

On the identification and frequency of the J and K cholinesterase phenotypes in a Caucasian population.

1984 • 50 citations

Ultrastructural localization of butyrylcholinesterase in senile plaques in the brains of aged and Alzheimer disease patients

1997 • 49 citations

Genetic mutations of butyrylcholine esterase identified from phenotypic abnormalities in Japan

1997 • 48 citations

Analysis of the butyrylcholinesterase gene and nearby chromosome 3 markers in Alzheimer disease

1998 • 44 citations

Butyrylcholinesterase K variant and apolipoprotein E4 genes do not act in synergy in Finnish late-onset Alzheimer's disease patients

1998 • 43 citations

Cholinesterases colocalize with sites of neurofibrillary degeneration in aged and Alzheimer's brains

1994 • 42 citations

The butyrylcholinesterase gene is neither independently nor synergistically associated with late-onset AD in clinic- and community-based populations

1998 • 41 citations

Ultrastructural localization of butyrylcholinesterase on neurofibrillary degeneration sites in the brains of aged and Alzheimer's disease patients

1994 • 40 citations

Refinement of the localization of human butyrylcholinesterase to chromosome 3q26.1-q26.2 using a PCR-derived probe

1991 • 39 citations

A PCR based method to determine the Kalow allele of the cholinesterase gene: the E1k allele frequency and its significance in the normal population.

1994 • 25 citations

Plasma Cholinesterase Variants

1985 • 22 citations

Age Influences the Synergy between Butyrylcholinesterase K Variant and Apolipoprotein E ε4 in Late-Onset Alzheimer’s Disease

1998 • 4 citations