Development of a Humanized Monoclonal Antibody (MEDI‐493) with Potent In Vitro and In Vivo Activity against Respiratory Syncytial Virus

AN EPIDEMIOLOGIC STUDY OF ALTERED CLINICAL REACTIVITY TO RESPIRATORY SYNCYTIAL (RS) VIRUS INFECTION IN CHILDREN PREVIOUSLY VACCINATED WITH AN INACTIVATED RS VIRUS VACCINE

1969 • 1,010 citations

Prophylactic Administration of Respiratory Syncytial Virus Immune Globulin to High-Risk Infants and Young Children

1993 • 735 citations

Respiratory-Syncytial-Virus Infections, Reinfections and Immunity

1979 • 698 citations

Risk of respiratory syncytial virus infection for infants from low-income families in relationship to age, sex, ethnic group, and maternal antibody level

1981 • 677 citations

Respiratory Syncytial Viral Infection in Infants with Congenital Heart Disease

1982 • 608 citations

The G glycoprotein of human respiratory syncytial viruses of subgroups A and B: extensive sequence divergence between antigenically related proteins.

1987 • 502 citations

High-Level Expression of a Recombinant Antibody from Myeloma Cells Using a Glutamine Synthetase Gene as an Amplifiable Selectable Marker

1992 • 468 citations

Priming immunization determines T helper cytokine mRNA expression patterns in lungs of mice challenged with respiratory syncytial virus.

1993 • 397 citations

Respiratory syncytial virus infection in children with bronchopulmonary dysplasia.

1988 • 370 citations

Improved outcome of respiratory syncytial virus infection in a high-risk hospitalized population of Canadian children

1992 • 359 citations

Enhanced pulmonary histopathology induced by respiratory syncytial virus (RSV) challenge of formalin-inactivated RSV-immunized BALB/c mice is abrogated by depletion of interleukin-4 (IL-4) and IL-10

1994 • 352 citations

Reduction of Respiratory Syncytial Virus Hospitalization Among Premature Infants and Infants with Bronchopulmonary Dysplasia Using Respiratory Syncytial Virus Immune Globulin Prophylaxis

1997 • 317 citations

Neonatal Respiratory Syncytial Virus Infection

1979 • 304 citations

Neutralization epitopes of the F glycoprotein of respiratory syncytial virus: effect of mutation upon fusion function

1989 • 297 citations

A Controlled Trial of Aerosolized Ribavirin in Infants Receiving Mechanical Ventilation for Severe Respiratory Syncytial Virus Infection

1991 • 295 citations

Respiratory Syncytial Virus

2004 • 275 citations

Kinetic and Concentration Analysis Using BIA Technology

1994 • 272 citations

Enhanced pulmonary histopathology is observed in cotton rats immunized with formalin-inactivated respiratory syncytial virus (RSV) or purified F glycoprotein and challenged with RSV 3–6 months after immunization

1990 • 270 citations

Quantitative aspects of passive immunity to respiratory syncytial virus infection in infant cotton rats

1985 • 247 citations

Role of respiratory syncytial virus in early hospitalizations for respiratory distress of young infants with cystic fibrosis

1988 • 235 citations

Immunoprophylaxis and immunotherapy of respiratory syncytial virus infection in the cotton rat

1985 • 219 citations

Antibody-Dependent Enhancement of Viral Infectivity

1986 • 207 citations

Respiratory Syncytial Virus-Induced Acute Lung Injury in Adult Patients with Bone Marrow Transplants

1989 • 203 citations

Human monoclonal Fab fragments derived from a combinatorial library bind to respiratory syncytial virus F glycoprotein and neutralize infectivity.

1992 • 181 citations

Respiratory syncytial virus

1993 • 176 citations

Immunization with Glycoprotein Subunits of Respiratory Syncytial Virus to Protect Cotton Rats Against Viral Infection

1987 • 162 citations

Reshaping a Human Monoclonal Antibody to Inhibit Human Respiratory Syncytial Virus Infection in Vivo

1991 • 162 citations

Role of Maternal Antibody in Pneumonia and Bronchiolitis Due to Respiratory Syncytial Vims

1976 • 160 citations

Mechanisms of immunity to respiratory syncytial virus in cotton rats

1983 • 136 citations

An update on approaches to the development of respiratory syncytial virus (RSV) and parainfluenza virus type 3 (PIV3) vaccines

1994 • 136 citations

Use of Ribavirin in the Treatment of Respiratory Syncytial Virus Infection

1993 • 126 citations

Respiratory Syncytial Virus Infections in Pediatric Liver Transplant Recipients

1992 • 125 citations

Protective epitopes on the fusion protein of respiratory syncytial virus recognized by murine and bovine monoclonal antibodies

1992 • 120 citations

Microneutralization test for respiratory syncytial virus based on an enzyme immunoassay

1985 • 115 citations

Protective Activity of a Human Respiratory Syncytial Virus Immune Globulin Prepared from Donors Screened by Microneutralization Assay

1992 • 103 citations

Studies of Passive Immunotherapy for Infections of Respiratory Syncytial Virus in the Respiratory Tract of a Primate Model

1985 • 100 citations

Passive transfer of respiratory syncytial virus (RSV) antiserum suppresses the immune response to the RSV fusion (F) and large (G) glycoproteins expressed by recombinant vaccinia viruses

1988 • 99 citations

The pathogenesis of respiratory syncytial virus infection in infant ferrets.

1976 • 93 citations

Model-building Studies of Antigen-binding Sites: The Hapten-binding Site of MOPC-315

1977 • 86 citations

Outbreak of respiratory syncytial virus infection in the elderly.

1980 • 79 citations

Antibody-Mediated Enhancement of Respiratory Syncytial Virus Infection in Two Monocyte/Macrophage Cell Lines

1989 • 73 citations

Noninfluenza Respiratory Virus Infection in Long-Term Care Facilities

1991 • 53 citations

Respiratory syncytial virus infections

1973 • 49 citations

Mechanism of antibody-mediated viral clearance in immunotherapy of respiratory syncytial virus infection of cotton rats

1990 • 40 citations

Respiratory syncytial virus infection and the immunocompromised host

1988 • 37 citations

Effect of passive antibody on the immune response of cotton rats to purified F and G glycoproteins of respiratory syncytial virus (RSV)

1991 • 29 citations

Topical Immunoprophylaxis of Respiratory Syncytial Virus (RSV)-Challenged Mice with RSV-Specific Immune Globulin

1995 • 26 citations

Use of the biotin-avidin system to study the specificity of antibodies against respiratory syncytial virus

1984 • 21 citations

RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, DOSE-ESCALATION TRIAL OF A HUMANIZED RESPIRATORY SYNCYTIAL VIRUS (RSV) MONOCLONAL ANTIBODY (MEDI-493) IN HIGH RISK INFANTS. • 768

1997 • 1 citations

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