An update on approaches to the development of respiratory syncytial virus (RSV) and parainfluenza virus type 3 (PIV3) vaccines

RESPIRATORY SYNCYTIAL VIRUS DISEASE IN INFANTS DESPITE PRIOR ADMINISTRATION OF ANTIGENIC INACTIVATED VACCINE12

1969 • 1,921 citations

AN EPIDEMIOLOGIC STUDY OF ALTERED CLINICAL REACTIVITY TO RESPIRATORY SYNCYTIAL (RS) VIRUS INFECTION IN CHILDREN PREVIOUSLY VACCINATED WITH AN INACTIVATED RS VIRUS VACCINE

1969 • 1,010 citations

FIELD EVALUATION OF A RESPIRATORY SYNCYTIAL VIRUS VACCINE AND A TRIVALENT PARAINFLUENZA VIRUS VACCINE IN A PEDIATRIC POPULATION1

1969 • 612 citations

Nonreplicating vaccinia vector efficiently expresses recombinant genes.

1992 • 598 citations

NYVAC: A highly attenuated strain of vaccinia virus

1992 • 473 citations

Priming immunization determines T helper cytokine mRNA expression patterns in lungs of mice challenged with respiratory syncytial virus.

1993 • 397 citations

Enhanced pulmonary histopathology induced by respiratory syncytial virus (RSV) challenge of formalin-inactivated RSV-immunized BALB/c mice is abrogated by depletion of interleukin-4 (IL-4) and IL-10

1994 • 352 citations

Expression of the F glycoprotein of respiratory syncytial virus by a recombinant vaccinia virus: comparison of the individual contributions of the F and G glycoproteins to host immunity.

1986 • 317 citations

Enhancement of respiratory syncytial virus pulmonary pathology in cotton rats by prior intramuscular inoculation of formalin-inactiva ted virus

1986 • 305 citations

Dissociation between serum neutralizing and glycoprotein antibody responses of infants and children who received inactivated respiratory syncytial virus vaccine

1986 • 302 citations

Antigenic relatedness between glycoproteins of human respiratory syncytial virus subgroups A and B: evaluation of the contributions of F and G glycoproteins to immunity

1987 • 273 citations

Pulmonary histopathology induced by respiratory syncytial virus (RSV) challenge of formalin-inactivated RSV-immunized BALB/c mice is abrogated by depletion of CD4+ T cells

1992 • 270 citations

Enhanced pulmonary histopathology is observed in cotton rats immunized with formalin-inactivated respiratory syncytial virus (RSV) or purified F glycoprotein and challenged with RSV 3–6 months after immunization

1990 • 270 citations

Pulmonary eosinophilic response to respiratory syncytial virus infection in mice sensitized to the major surface glycoprotein G

1992 • 228 citations

Immunoprophylaxis and immunotherapy of respiratory syncytial virus infection in the cotton rat

1985 • 219 citations

Immune and histopathological responses in animals vaccinated with recombinant vaccinia viruses that express individual genes of human respiratory syncytial virus

1987 • 215 citations

Respiratory syncytial virus (RSV) F, G, M2 (22K), and N proteins each induce resistance to RSV challenge, but resistance induced by M2 and N proteins is relatively short-lived

1991 • 204 citations

Effect of age and preexisting antibody on serum antibody response of infants and children to the F and G glycoproteins during respiratory syncytial virus infection

1986 • 192 citations

Cell-mediated Immunity to Respiratory Syncytial Virus Induced by Inactivated Vaccine or by Infection

1976 • 186 citations

Serum and nasal-wash immunoglobulin G and A antibody response of infants and children to respiratory syncytial virus F and G glycoproteins following primary infection

1986 • 172 citations

Immunization with Glycoprotein Subunits of Respiratory Syncytial Virus to Protect Cotton Rats Against Viral Infection

1987 • 162 citations

CD4+ T cells clear virus but augment disease in mice infected with respiratory syncytial virus. Comparison with the effects of CD8+ T cells

1992 • 157 citations

Cotton rats previously immunized with a chimeric RSV FG glycoprotein develop enhanced pulmonary pathology when infected with RSV, a phenomenon not encountered following immunization with vaccinia—RSV recombinants or RSV

1992 • 147 citations

Vaccines 90: Modern approaches to new vaccines including prevention of AIDS

1991 • 137 citations

Expression of the fusion protein of human respiratory syncytial virus from recombinant vaccinia virus vectors and protection of vaccinated mice

1987 • 132 citations

Expression of the F and HN glycoproteins of human parainfluenza virus type 3 by recombinant vaccinia viruses: contributions of the individual proteins to host immunity

1987 • 129 citations

Immunogenicity and Safety of Respiratory Syncytial Virus Subunit Vaccine in Seropositive Children 18-36 Months Old

1993 • 126 citations

Resistance to human respiratory syncytial virus (RSV) infection induced by immunization of cotton rats with a recombinant vaccinia virus expressing the RSV G glycoprotein.

1986 • 117 citations

Strain-Specific Serum Antibody Responses in Infants Undergoing Primary Infection with Respiratory Syncytial Virus

1988 • 112 citations

Potential use of non-replicating vectors as recombinant vaccines

1992 • 110 citations

Immunization of cotton rats with the fusion (F) and large (G) glycoproteins of respiratory syncytial virus (RSV) protects against RSV challenge without potentiating RSV disease

1989 • 105 citations

A Human Respiratory Syncytial Virus (RSV) Primate Model of Enhanced Pulmonary Pathology Induced with a Formalin-Inactivated RSV Vaccine but Not a Recombinant FG Subunit Vaccine

1993 • 104 citations

Current approaches to the development of vaccines effective against parainfluenza and respiratory syncytial viruses

1988 • 100 citations

A further attenuated derivative of a cold-passaged temperature-sensitive mutant of human respiratory syncytial virus retains immunogenicity and protective efficacy against wild-type challenge in seronegative chimpanzees

1994 • 99 citations

Passive transfer of respiratory syncytial virus (RSV) antiserum suppresses the immune response to the RSV fusion (F) and large (G) glycoproteins expressed by recombinant vaccinia viruses

1988 • 99 citations

Protection of BALE/c mice from respiratory syncytial virus infection by immunization with a synthetic peptide derived from the G glycoprotein

1991 • 96 citations

Low-Temperature-Grown RS Virus in Adult Volunteers

1968 • 96 citations

A comparison in chimpanzees of the immunogenicity and efficacy of live attenuated respiratory syncytial virus (RSV) temperature-sensitive mutant vaccines and vaccinia virus recombinants that express the surface glycoproteins of RSV

1993 • 93 citations

Cytolytic T-lymphocyte responses to respiratory syncytial virus: effector cell phenotype and target proteins

1990 • 90 citations

Immunogenicity of Purified F Glycoprotein of Respiratory Syncytial Virus: Clinical and Immune Responses to Subsequent Natural Infection in Children

1993 • 85 citations

Cold adaptation of parainfluenza virus type 3: Induction of three phenotypic markers

1982 • 83 citations

Evaluation of bovine, cold-adapted human, and wild-type human parainfluenza type 3 viruses in adult volunteers and in chimpanzees

1991 • 83 citations

Nucleotide sequence analysis and expression from recombinant vectors demonstrate that the attachment protein G of bovine respiratory syncytial virus is distinct from that of human respiratory syncytial virus

1990 • 83 citations

Attenuation of Bovine Parainfluenza Virus Type 3 in Nonhuman Primates and Its Ability to Confer Immunity to Human Parainfluenza Virus Type 3 Challenge

1988 • 83 citations

Satisfactorily attenuated and protective mutants derived from a partially attenuated cold-passaged respiratory syncytial virus mutant by introduction of additional attenuating mutations during chemical mutagenesis

1994 • 81 citations

Respiratory syncytial virus infection in anti-mu-treated mice

1991 • 76 citations

The respiratory syncytial virus subgroup B attachment glycoprotein: analysis of sequence, expression from a recombinant vector, and evaluation as an immunogen against homologous and heterologous subgroup virus challenge

1990 • 75 citations

The Purification of Four Respiratory Syncytial Virus Proteins and Their Evaluation as Protective Agents against Experimental Infection in BALB/c Mice

1988 • 71 citations

Evaluation in chimpanzees of vaccinia virus recombinants that express the surface glycoproteins of human respiratory syncytial virus

1990 • 69 citations

Cold-passaged human parainfluenza type 3 viruses contain ts and non-ts mutations leading to attenuation in rhesus monkeys

1992 • 69 citations

Expression of biologically active and antigenically authentic parainfluenza Type 3 virus hemagglutinin-neuraminidase glycoprotein by a recombinant baculovirus

1987 • 69 citations

Immunogenicity of Recombinant Adenovirus-Respiratory Syncytial Virus Vaccines with Adenovirus Types 4, 5, and 7 Vectors in Dogs and a Chimpanzee

1992 • 69 citations

The cytolytic activity of pulmonary CD8+ lymphocytes, induced by infection with a vaccinia virus recombinant expressing the M2 protein of respiratory syncytial virus (RSV), correlates with resistance to RSV infection in mice

1993 • 68 citations

Serum immunoglobulin G antibody subclass response to respiratory syncytial virus F and G glycoproteins after first, second, and third infections

1989 • 68 citations

Initiation of cytotoxic T-cell response and protection of Balb/c mice by vaccination with an experimental ISCOMs respiratory syncytial virus subunit vaccine

1992 • 66 citations

Secretory Antibody Response to Respiratory Syncytial Virus Infection

1981 • 63 citations

Protection of Cotton Rats against Human Respiratory Syncytial Virus by Vaccination with a Novel Chimeric FG Glycoprotein

1989 • 61 citations

Immunization of Cotton Rats with the Human Respiratory Syncytial Virus F Glycoprotein Produced Using a Baculovirus Vector

1989 • 59 citations

Immunogenicity and pathogenicity of a triple temperature-sensitive modified respiratory syncytial virus in adult volunteers

1993 • 56 citations

Group-Specific Serum Antibody Responses in Children with Primary and Recurrent Respiratory Syncytial Virus Infections

1991 • 55 citations

Nucleotide sequence analysis of the bovine respiratory syncytial virus fusion protein mRNA and expression from a recombinant vaccinia virus

1991 • 52 citations

Nucleotide sequence of the bovine parainfluenza 3 virus genome: the genes of the F and HN glycoproteins

1987 • 52 citations

Characterization of a Novel Human Respiratory Syncytial Virus Chimeric FG Glycoprotein Expressed Using a Baculovirus Vector

1989 • 48 citations

Vaccination of Cotton Rats with a Chimeric FG Glycoprotein of Human Respiratory Syncytial Virus Induces Minimal Pulmonary Pathology on Challenge

1991 • 48 citations

Evaluation in non-human primates of the safety, immunogenicity and efficacy of recombinant vaccinia viruses expressing the F or G glycoprotein of respiratory syncytial virus

1988 • 46 citations

Microencapsulated Human Parainfluenza Virus Induces a Protective Immune Response

1993 • 46 citations

Evaluation of a live attenuated, cold-adapted parainfluenza virus type 3 vaccine in children

1992 • 45 citations

Immunization with vaccinia virus recombinants that express the surface glycoproteins of human parainfluenza virus type 3 (PIV3) protects patas monkeys against PIV3 infection

1988 • 44 citations

Comparison of the ability of formalin-inactivated respiratory syncytial virus, immunopurified F, G and N proteins and cell lysate to enhance pulmonary changes in Balb/c mice

1992 • 41 citations

Antibody responses of humans and nonhuman primates to individual antigenic sites of the hemagglutinin-neuraminidase and fusion glycoproteins after primary infection or reinfection with parainfluenza type 3 virus

1990 • 38 citations

Low-temperature-grown RS virus in adult volunteers

1968 • 36 citations

Intranasal Immunization of Hamsters with Envelope Glycoproteins of Human Parainfluenza Virus Type 3

1988 • 36 citations

Evaluation of the immunogenicity and protective efficacy of a candidate parainfluenza virus type 3 subunit vaccine in cotton rats

1991 • 35 citations

Protection of cotton rats against human parainfluenza virus type 3 by vaccination with a chimeric FHN subunit glycoprotein

1993 • 35 citations

Immunosuppression of the Antibody Response to Respiratory Syncytial Virus (RSV) by Pre-existing Serum Antibodies: Partial Prevention by Topical Infection of the Respiratory Tract with Vaccinia Virus-RSV Recombinants

1989 • 33 citations

Comparison of soluble and secreted forms of human parainfluenza virus type 3 glycoproteins expressed from mammalian and insect cells as subunit vaccines

1993 • 32 citations

Evaluation of cold‐adapted adn temperature‐sensitive mutants of parainfluenza virus type 3 in weanling hamsters

1984 • 31 citations

A Cold-Adapted Mutant of Parainfluenza Virus Type 3 Is Attenuated and Protective in Chimpanzees

1993 • 30 citations

Effect of passive antibody on the immune response of cotton rats to purified F and G glycoproteins of respiratory syncytial virus (RSV)

1991 • 29 citations

Bovine respiratory syncytial virus protects cotton rats against human respiratory syncytial virus infection

1993 • 29 citations

Synthetic peptides corresponding to the F protein of RSV stimulate murine B and T cells but fail to confer protection

1991 • 28 citations

The complete nucleotide sequence of two cold-adapted, temperature-sensitive attenuated mutant vaccine viruses (cp12 and cp45) derived from the JS strain of human parainfluenza virus type 3 (PIV3)

1993 • 27 citations

Current approaches to the development of vaccines effective against parainfluenza viruses.

1988 • 26 citations

Protection of weanling hamsters from experimental infection with wild‐type parainfluenza virus type 3 (para 3) by cold‐adapted mutants of para 3

1986 • 25 citations

Expression of the G glycoprotein gene of human respiratory syncytial virus in Salmonella typhimurium

1993 • 25 citations

Lack of detectable enhanced pulmonary histopathology in cotton rats immunized with purified F glycoprotein of respiratory syncytial virus (RSV) when challenged at 3–6 months after immunization

1993 • 23 citations

Protection of cotton rats by immunization with the human parainfluenza virus type 3 fusion (F) glycoprotein expressed on the surface of insect cells infected with a recombinant baculovirus

1991 • 23 citations

Development of a novel subunit vaccine that protects cotton rats against both human respiratory syncytial virus and human parainfluenza virus type 3

1993 • 23 citations

Comparative analysis of the immunostimulatory properties of different adjuvants on the immunogenicity of a prototype parainfluenza virus type 3 subunit vaccine

1992 • 18 citations

Induction of a neutralizing immune response to human respiratory syncytial virus with anti-idiotypic antibodies

1990 • 16 citations

A chimeric glycoprotein of human respiratory syncytial virus termed FG induces T-cell mediated immunity in mice

1991 • 14 citations

The Envelope Proteins from Purified Respiratory Syncytial Virus Protect Mice from Intranasal Virus Challenge

1989 • 8 citations