Aromatase inhibitors: mechanism of action and role in the treatment of breast cancer

Breast cancer and hormone replacement therapy: collaborative reanalysis of data from 51 epidemiological studies of 52 705 women with breast cancer and 108 411 women without breast cancer

1997 • 2,438 citations

ON THE TREATMENT OF INOPERABLE CASES OF CARCINOMA OF THE MAMMA: SUGGESTIONS FOR A NEW METHOD OF TREATMENT, WITH ILLUSTRATIVE CASES.

1896 • 1,633 citations

Aromatase Cytochrome P450, The Enzyme Responsible for Estrogen Biosynthesis*

1994 • 1,428 citations

Letrozole Is More Effective Neoadjuvant Endocrine Therapy Than Tamoxifen for ErbB-1– and/or ErbB-2–Positive, Estrogen Receptor–Positive Primary Breast Cancer: Evidence From a Phase III Randomized Trial

2001 • 1,075 citations

Utilization of Oxygen and Reduced Nicotinamide Adenine Dinucleotide Phosphate by Human Placental Microsomes during Aromatization of Androstenedione

1974 • 693 citations

A Prospective Study of Endogenous Estrogens and Breast Cancer in Postmenopausal Women

1995 • 635 citations

Influence of Letrozole and Anastrozole on Total Body Aromatization and Plasma Estrogen Levels in Postmenopausal Breast Cancer Patients Evaluated in a Randomized, Cross-Over Study

2002 • 572 citations

Endogenous concentration and subcellular distribution of androgens in normal and malignant human breast tissue.

1985 • 446 citations

Menopause and Breast Cancer Risk<xref ref-type="fn" rid="FN2">2</xref>

1972 • 421 citations

Chapter 3: Endogenous Estrogens as Carcinogens Through Metabolic Activation

2000 • 396 citations

Isolation of a full-length cDNA insert encoding human aromatase system cytochrome P-450 and its expression in nonsteroidogenic cells.

1988 • 302 citations

An association between the allele coding for a low activity variant of catechol-O-methyltransferase and the risk for breast cancer.

1997 • 286 citations

The importance of local synthesis of estrogen within the breast

1987 • 280 citations

Chapter 5: Tissue-Specific Synthesis and Oxidative Metabolism of Estrogens

2000 • 261 citations

Use of alternative promoters to express the aromatase cytochrome P450 (CYP19) gene in breast adipose tissues of cancer-free and breast cancer patients.

1996 • 250 citations

Inactivation of aromatase in vitro by 4-hydroxy-4-androstene-3,17-dione and 4-acetoxy-4-androstene-3,17-dione and sustained effects in vivo

1981 • 215 citations

Regulation of Estrogen Biosynthesis by Human Adipose Cells*

1989 • 177 citations

Concentration of Sex Steroids in Adipose Tissue after Menopause

1998 • 170 citations

SEX HORMONE LEVELS IN SERUM IN RELATION TO THE DEVELOPMENT OF BREAST CANCER

1987 • 164 citations

in situ oestrone synthesis in normal breast and breast tumour tissues: Effect of treatment with 4‐hydroxyandrostenedione

1989 • 157 citations

6-Methylenandrosta-1,4-diene-3,17-dione (FCE 24304): A new irreversible aromatase inhibitor

1988 • 148 citations

Aromatase activity in breast tissue

1991 • 144 citations

Structural characterization of the human estrogen synthetase (aromatase) gene

1990 • 143 citations

Regulation of aromatase activity within the breast

1997 • 105 citations

Biology of aromatase inhibitors: pharmacology/endocrinology within the breast.

1999 • 104 citations

Aromatase inhibitors: synthesis, biological activity, and binding mode of azole-type compounds

1993 • 100 citations

Local endocrine effects of aromatase inhibitors within the breast

2001 • 85 citations

Aromatase inhibitors in the treatment of breast cancer

1994 • 81 citations

Aromatase inhibitors ? mechanisms of steroidal inhibitors

1994 • 75 citations

Pathological features of breast cancer response following neoadjuvant treatment with either letrozole or tamoxifen

2003 • 72 citations

Breast tumor aromatase: functional role and transcriptional regulation.

1999 • 69 citations

Mechanism of human placental aromatase: A new active site model

1993 • 67 citations

Structure-activity relationships and binding model of novel aromatase inhibitors

1993 • 54 citations

Aromatease, its inhibitors and their use in breast cancer treatment

1993 • 52 citations

Endocrine changes with the aromatase inhibitor fadrozole hydrochloride in breast cancer

1994 • 44 citations

Aromatase Inhibition and Breast Cancer

2006 • 31 citations

Induction of aromatase expression by aminoglutethimide, an aromatase inhibitor that is used to treat breast cancer in postmenopausal women.

1999 • 24 citations