Deletional, mutational, and methylation analyses of CDKN2 (p16/MTS1) in primary and metastatic prostate cancer

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

1993 • 3,680 citations

A Cell Cycle Regulator Potentially Involved in Genesis of Many Tumor Types

1994 • 2,821 citations

5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers

1995 • 2,000 citations

Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers

1994 • 1,806 citations

Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma.

1994 • 1,542 citations

Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers.

1995 • 1,353 citations

Germline p16 mutations in familial melanoma

1994 • 1,241 citations

The essentials of DNA methylation

1992 • 960 citations

Cytidine methylation of regulatory sequences near the pi-class glutathione S-transferase gene accompanies human prostatic carcinogenesis.

1994 • 840 citations

Methylation of the 5' CpG island of the p16/CDKN2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing.

1995 • 713 citations

High levels of De Novo methylation and altered chromatin structure at CpG islands in cell lines

1990 • 709 citations

Frequency of homozygous deletion at p16/CDKN2 in primary human tumours

1995 • 653 citations

Mutations and altered expression of p16INK4 in human cancer.

1994 • 547 citations

CDKN2/p16 or RB alterations occur in the majority of glioblastomas and are inversely correlated.

1996 • 404 citations

Homozygous deletion and frequent allelic loss of chromosome 8p22 loci in human prostate cancer.

1993 • 364 citations

Reduction of E-cadherin levels and deletion of the alpha-catenin gene in human prostate cancer cells.

1993 • 294 citations

Silencing of p16/CDKN2 expression in human gliomas by methylation and chromatin condensation.

1996 • 251 citations

Mutation and altered expression of p16^ in human cancer

1994 • 234 citations

Mutations in the p16(INK4)/MTS1/CDKN2, p15(INK4B)/MTS2, and p18 genes in primary and metastatic lung cancer

1995 • 208 citations

Abnormal patterns of DNA methylation in human neoplasia: potential consequences for tumor progression.

1991 • 207 citations

Allelic loss of the retinoblastoma gene in primary human prostatic adenocarcinomas

1995 • 129 citations

In vivo occurrence of p16 (MTS1) and p15 (MTS2) alterations preferentially in non-small cell lung cancers.

1995 • 115 citations

Regional DNA hypermethylation at D17S5 precedes 17p structural changes in the progression of renal tumors.

1993 • 95 citations

Frequent mutations of CDKN2 in primary pancreatic adenocarcinomas

1995 • 82 citations

Mutational Analysis of CDKN2 (CDK4I/MTS1) Gene in Tissues and Cell Lines of Human Prostate Cancer

1995 • 58 citations

Molecular genetics of prostate cancer.

1995 • 50 citations

Correction: Corrigendum: Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma

1994 • 4 citations