Antimicrobial polypeptides of human neutrophils

Defensins. Natural peptide antibiotics of human neutrophils.

1985 • 1,411 citations

Iron Transport and Storage Proteins

1980 • 1,183 citations

Subcellular localization of the b-cytochrome component of the human neutrophil microbicidal oxidase: translocation during activation.

1983 • 938 citations

Interaction of human defensins with Escherichia coli. Mechanism of bactericidal activity.

1989 • 695 citations

A Bactericidal Effect for Human Lactoferrin

1977 • 688 citations

An iron-binding protein common to many external secretions

1966 • 589 citations

Human leukocyte granule elastase: rapid isolation and characterization

1976 • 550 citations

Primary structures of three human neutrophil defensins.

1985 • 529 citations

Direct inactivation of viruses by human granulocyte defensins

1986 • 525 citations

Bactericidal activity of human lactoferrin: sensitivity of a variety of microorganisms

1980 • 494 citations

Monocyte-chemotactic activity of defensins from human neutrophils.

1989 • 486 citations

The beige mutation in the mouse selectively impairs natural killer cell function

1979 • 467 citations

Wegener's granulomatosis autoantibodies identify a novel diisopropylfluorophosphate-binding protein in the lysosomes of normal human neutrophils.

1989 • 439 citations

The respiratory burst of phagocytic cells is associated with a rise in vacuolar pH

1981 • 429 citations

BIOCHEMICAL AND MORPHOLOGICAL CHARACTERIZATION OF AZUROPHIL AND SPECIFIC GRANULES OF HUMAN NEUTROPHILIC POLYMORPHONUCLEAR LEUKOCYTES

1974 • 427 citations

The Chediak-Higashi syndrome: studies in four patients and a review of the literature.

1972 • 398 citations

Anti-neutrophil cytoplasm antibodies in Wegener's granulomatosis recognize an elastinolytic enzyme.

1990 • 397 citations

Character of azurophil and specific granules purified from human polymorphonuclear leukocytes.

1974 • 340 citations

Lactoferrin enhances hydroxyl radical production by human neutrophils, neutrophil particulate fractions, and an enzymatic generating system.

1981 • 338 citations

Insect immunity: isolation from immune blood of the dipteran Phormia terranovae of two insect antibacterial peptides with sequence homology to rabbit lung macrophage bactericidal peptides.

1989 • 325 citations

Absence of both cytochrome b−245 subunits from neutrophils in X-linked chronic granulomatous disease

1987 • 324 citations

Inhibition of bacteria by lactoferrin and other iron-chelating agents

1968 • 313 citations

Assessment of chlorination by human neutrophils

1983 • 285 citations

Anti-neutrophil cytoplasmic autoantibody-associated glomerulonephritis and vasculitis.

1989 • 264 citations

Granzymes, a Family of Serine Proteases Released from Granules of Cytolytic T Lymphocytes upon T Cell Receptor Stimulation

1988 • 263 citations

Bactericidal Activity of Human Lactoferrin: Differentiation from the Stasis of Iron Deprivation

1982 • 257 citations

Developmental regulation of cryptdin, a corticostatin/defensin precursor mRNA in mouse small intestinal crypt epithelium.

1989 • 254 citations

Mechanisms of Enzymatic Bacteriolysis

1967 • 243 citations

Characterization and quantification of the peroxidase in human monocytes

1978 • 238 citations

Leukocyte adhesion receptors are stored in peroxidase-negative granules of human neutrophils.

1987 • 229 citations

Primary structure of human neutrophil elastase.

1987 • 227 citations

Purification of three antibacterial proteins from the culture medium of NIH-Sape-4, an embryonic cell line of Sarcophaga peregrina.

1988 • 214 citations

Microbicidal/cytotoxic proteins of neutrophils are deficient in two disorders: Chediak-Higashi syndrome and "specific" granule deficiency.

1988 • 195 citations

Chediak-Higashi gene in humans. I. Impairment of natural - killer function

1980 • 193 citations

Direct inactivation of viruses by MCP-1 and MCP-2, natural peptide antibiotics from rabbit leukocytes

1985 • 180 citations

Lactoferrin Deficiency Associated with Altered Granulocyte Function

1982 • 172 citations

Characterization of cDNA clones for human myeloperoxidase: Predicted amino acid sequence and evidence for multiple mRNA species

1987 • 169 citations

Activity of rabbit leukocyte peptides against Candida albicans

1985 • 167 citations

Defensin-rich dense granules of human neutrophils

1987 • 162 citations

Specific degranulation of human polymorphonuclear leukocytes

1974 • 162 citations

CAP37, a human neutrophil-derived chemotactic factor with monocyte specific activity.

1990 • 151 citations

Microbicidal cationic proteins in rabbit alveolar macrophages: a potential host defense mechanism

1980 • 150 citations

Cationic Proteins of Polymorphonuclear Leukocyte Lysosomes I. Resolution of Antibacterial and Enzymatic Activities

1966 • 142 citations

Phagocytosis in Chronic Granulomatous Disease and the Chediak–Higashi Syndrome

1972 • 141 citations

Analytical Subcellular Fractionation of Human Granulocytes with Reference to the Localization of Vitamin B12-Binding Proteins

1975 • 140 citations

Bactericidal activity of human lactoferrin: influence of physical conditions and metabolic state of the target microorganism

1981 • 138 citations

Mechanism of target cytolysis by peptide defensins. Target cell metabolic activities, possibly involving endocytosis, are crucial for expression of cytotoxicity.

1988 • 137 citations

Killing and Lysis of Gram-negative Bacteria Through the Synergistic Effect of Hydrogen Peroxide, Ascorbic Acid, and Lysozyme

1969 • 136 citations

An Anomaly of Neutrophil Morphology with Impaired Function

1974 • 124 citations

Lysis and killing of bacteria by lysosomal proteinases

1976 • 116 citations

Observations on a Bacteriolytic Substance (“Lysozyme”) Found in Secretions and Tissues

1922 • 115 citations

Chromosomal gene structure of human myeloperoxidase and regulation of its expression by granulocyte colony-stimulating factor.

1987 • 113 citations

Solution structures of the rabbit neutrophil defensin NP-5

1988 • 105 citations

THE PROPERTIES OF LYSOZYME AND ITS ACTION ON MICROORGANISMS

1957 • 103 citations

Intracellular and Extracellular Degranulation of Human Polymorphonuclear Azurophil and Specific Granules Induced by Immune Complexes

1974 • 100 citations

Natural killer (HNK-1+) cells in Chediak-Higashi patients are present in normal numbers but are abnormal in function and morphology.

1982 • 99 citations

Salmonella virulence: new clues to intramacrophage survival

1990 • 97 citations

Identification and sequencing of cDNA clones encoding the granule-associated serine proteases granzymes D, E, and F of cytolytic T lymphocytes.

1988 • 92 citations

The structure of the rabbit macrophage defensin genes and their organ-specific expression.

1989 • 92 citations

Structure of a novel human granulocyte peptide with anti-ACTH activity

1988 • 90 citations

Leukocyte candidacidal activity and resistance to systemic candidiasis in patients with cancer

1971 • 87 citations

Specific protease deficiency in polymorphonuclear leukocytes of Chédiak-Higashi syndrome and beige mice.

1978 • 85 citations

Microbicidal cationic proteins of rabbit alveolar macrophages: amino acid composition and functional attributes

1981 • 83 citations

Isolation and structure of corticostatin peptides from rabbit fetal and adult lung.

1988 • 80 citations

Assignment of defensin gene(s) to human chromosome 8p23

1989 • 80 citations

LYSOSOMAL AND ULTRASTRUCTURAL CHANGES IN HUMAN "TOXIC" NEUTROPHILS DURING BACTERIAL INFECTION

1969 • 79 citations

Human neutrophil gelatinase is a component of specific granules.

1989 • 77 citations

Neutrophil Killing of Bacteria by Oxygen-Independent Mechanisms: A Historical Summary

1985 • 73 citations

Abnormal neutrophil maturation in a neutrophil defect with morphologic abnormality and impaired function

1979 • 71 citations

Refractory Megaloblastic Anemia with Myeloperoxidase-Deficient Neutrophils

1972 • 71 citations

Synergistic cytolysis mediated by hydrogen peroxide combined with peptide defensins

1988 • 68 citations

Giant granules and widespread cytoplasmic inclusions in a genetic syndrome of Aleutian mink. An electron microscopic study.

1965 • 65 citations

Lysosomal elastase and cathepsin G in beige mice. Neutrophils of beige (Chediak-Higashi) mice selectively lack lysosomal elastase and cathepsin G.

1986 • 65 citations

Two-dimensional NMR studies of the antimicrobial peptide NP-5

1987 • 64 citations

LYSOZYME: ITS ABSENCE IN TEARS AND LEUKOCYTES OF CATTLE

1967 • 63 citations

Processing of a newly identified intermediate of human myeloperoxidase in isolated granules occurs at neutral pH.

1986 • 61 citations

Selective defect in myeloid cell lactoferrin gene expression in neutrophil specific granule deficiency.

1989 • 58 citations

Assignment of the lactotransferrin gene to human chromosome 3 and to mouse chromosome 9

1987 • 57 citations

Ultrastructural quantitation of peroxidase- and elastase-containing granules in human neutrophils.

1988 • 55 citations

The corticostatic (anti-ACTH) and cytotoxic activity of peptides isolated from fetal, adult and tumor-bearing lung

1987 • 55 citations

Myeloperoxidase precursors incorporate heme.

1987 • 50 citations

Defective bactericidal activity and absence of specific granules in neutrophils from a patient with recurrent bacterial infections

1984 • 49 citations

HISTOCHEMICAL DEMONSTRATION OF SULFATED MUCOSUBSTANCES AND CATIONIC PROTEINS IN HUMAN GRANULOCYTES AND PLATELETS

1969 • 47 citations

Localization of myeloperoxidase to the long arm of human chromosome 17: relationship to the 15; 17 translocation of acute promyelocytic leukemia.

1987 • 47 citations

Isolation and characterization of a cDNA coding for human myeloperoxidase

1987 • 46 citations

Solution structures of proteins from NMR data and modeling: alternative folds for neutrophil peptide 5

1989 • 45 citations

Newborn rabbit alveolar macrophages are deficient in two microbicidal cationic peptides, MCP-1 and MCP-2.

1985 • 43 citations

The processing and intracellular transport of myeloperoxidase. Modulation by lysosomotropic agents and monensin.

1986 • 43 citations

Evidence for and partial characterization of three major and three minor chromatographic forms of human neutrophil myeloperoxidase

1986 • 41 citations

Abnormal neutrophils in acute myeloid leukemia and myelodysplastic syndrome

1988 • 38 citations

Cytotoxicity of rabbit macrophage peptides MCP-1 and MCP-2 for mouse tumor cells

1985 • 34 citations

Giant platelet granules in a child with the chediak‐higashi syndrome

1979 • 32 citations

Lysozyme deficiency-an inherited disorder of rabbits.

1974 • 31 citations

Chromosomal localization of human lactotransferrin gene (LTF) by in situ hybridization

1988 • 30 citations

Immunocytochemical identification of abnormal polymorphonuclear neutrophils in patients with leukemia.

1978 • 26 citations

Inhibitors of elastase and cathepsin G in Chédiak-Higashi (beige) neutrophils

1989 • 26 citations

Elastase and cathepsin G activities are present in immature bone marrow neutrophils and absent in late marrow and circulating neutrophils of beige (Chediak-Higashi) mice.

1987 • 22 citations

The Chediak-Higashi syndrome: quantitation of a deficiency in maximal bactericidal capacity.

1979 • 22 citations

Structural characterization of the isoenzymatic forms of human myeloperoxidase

1987 • 18 citations

Isolation of a cDNA clone encoding a novel form of granzyme B from human NK cells and mapping to chromosome 14

1990 • 17 citations

In vitro tumor cell cytolysis mediated by peptide defensins of human and rabbit granulocytes

1986 • 17 citations

Isolation and characterization of human defensin cDNA clones

1989 • 16 citations

The Neutrophil: Function and Clinical Disorders

1980 • 13 citations

Human neutrophil-specific granule deficiency: a model to assess the role of neutrophil-specific granules in the evolution of the inflammatory response

1982 • 13 citations

Quantitative cytochemistry of the toxic granulation blood neutrophil

1983 • 13 citations

Chédiak-Higashi syndrome neutrophils are characterized by the absence of both normal azurophilic granules.

1986 • 12 citations

Ultrastructural localization of lactoferrin and myeloperoxidase in human neutrophils by immunogold

1985 • 12 citations

Abnormal peroxidase-positive granules in “specific granule” deficiency

1989 • 11 citations

Human neutrophils contain an intracellular pool of putative receptors for the chemoattractant N-formyl-methionyl-leucyl-phenylalanine

1983 • 10 citations

Hereditary myeloperoxidase deficiency

1979 • 9 citations

High resolution of heterogeneity among human neutrophil granules: physical, biochemical, and ultrastructural properties of isolated fractions

1986 • 8 citations

Analysis of the peptide subunits of human neutrophil myeloperoxidase

1986 • 7 citations

Phagolysosomal pH of human neutrophils

1984 • 7 citations

Heterogeneity of human neutrophil phagolysosomes: functional consequences for candidacidal activity

1984 • 7 citations

Murine lymphocytes with natural killer activity express CTL-derived serine protease genes.

1989 • 6 citations

Aberrant restriction endonuclease digests of DNA from subjects with hereditary myeloperoxidase deficiency

1989 • 4 citations

Biosynthesis and processing of lactoferrin in bone marrow cells, a comparison with processing of myeloperoxidase

1988 • 3 citations

Evidence for a pretranslational defect in hereditary and acquired myeloperoxidase deficiency

1989 • 3 citations

Human myeloperoxidase gene: molecular cloning and expression in leukemic cells

1986 • 3 citations

Abnormalities in granule formation in acute myelogenous leukemia

1977 • 3 citations

Development of the granule population in neutrophil granulocytes from human bone marrow

1984 • 3 citations

Abnormal distribution of complex carbohydrates in neutrophils of a patient with lactoferrin deficiency

1983 • 2 citations

Human neutrophil dysfunction with giant granules and defective activation of the respiratory burst

1983 • 1 citations