A Synthetic Peptide Homologous to Retroviral Transmembrane Envelope Proteins Depresses Protein Kinase C Mediated Lymphocyte Proliferation and Directly Inactivated Protein Kinase C: A Potential Mechanism for Immunosuppression

The role of protein kinase C in cell surface signal transduction and tumour promotion

1984 • 7,521 citations

Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide-dependent protein kinase and protein kinase C

1984 • 2,728 citations

Phorbol diester receptor copurifies with protein kinase C.

1983 • 1,185 citations

Protein kinase C as a possible receptor protein of tumor-promoting phorbol esters.

1983 • 890 citations

[1] Assays of protein kinase

1983 • 832 citations

Early steps of lymphocyte activation bypassed by synergy between calcium ionophores and phorbol ester

1985 • 753 citations

Brief Report: Simplified Myeloperoxidase Stain Using Benzidine Dihydrochloride

1965 • 673 citations

Proteolytic activation of calcium-activated, phospholipid-dependent protein kinase by calcium-dependent neutral protease.

1983 • 601 citations

Commentary: “The Role of T3 Surface Molecules in the Activation of Human Cells: A Two-Stimulus Requirement for IL-2 Production Reflects Events Occurring at a Pretranslational Level”

2015 • 572 citations

SIMPLIFIED MYELOPEROXIDASE STAIN USING BENZIDINE DIHYDROCHLORIDE.

1965 • 540 citations

Activation of protein kinase C by Triton X-100 mixed micelles containing diacylglycerol and phosphatidylserine.

1985 • 471 citations

The role of T3 surface molecules in the activation of human T cells: a two-stimulus requirement for IL 2 production reflects events occurring at a pre-translational level.

1984 • 455 citations

Inhibition of Lymphocyte Proliferation by a Synthetic Peptide Homologous to Retroviral Envelope Proteins

1985 • 433 citations

Diacylglycerols mimic phorbol diester induction of leukemic cell differentiation.

1985 • 234 citations

The involvement of calpain in the activation of protein kinase C in neutrophils stimulated by phorbol myristic acid.

1986 • 228 citations

The antigen receptor on a human T cell line initiates activation by increasing cytoplasmic free calcium.

1985 • 223 citations

Protein kinase C and calcium ion in mitogenic response of macrophage-depleted human peripheral lymphocytes.

1985 • 220 citations

Binding of protein kinase C to neutrophil membranes in the presence of Ca2+ and its activation by a Ca2+-requiring proteinase.

1985 • 193 citations

sn-1,2-Dioctanoylglycerol. A cell-permeable diacylglycerol that mimics phorbol diester action on the epidermal growth factor receptor and mitogenesis.

1985 • 179 citations

Domain structure and phosphorylation of protein kinase C.

1987 • 168 citations

The role of protein kinase C in transmembrane signaling by the T cell antigen receptor complex. Effects of stimulation with soluble or immobilized CD3 antibodies.

1987 • 153 citations

Valency of CD3 binding and internalization of the CD3 cell-surface complex control T cell responses to second signals: distinction between effects on protein kinase C, cytoplasmic free calcium, and proliferation.

1986 • 139 citations

Abrogation of lymphocyte blastogenesis by a feline leukaemia virus protein

1978 • 135 citations

Immunosuppressive activity of the retroviral envelope protein P 15E and its possible relationship to neoplasia

1984 • 127 citations

Requirements for the simultaneous presence of phorbol esters and calcium ionophores in the expression of human T lymphocyte proliferation-related genes.

1987 • 122 citations

Inhibitors of monocyte responses to chemotaxins are present in human cancerous effusions and react with monoclonal antibodies to the P15(E) structural protein of retroviruses.

1981 • 119 citations

Biochemical responses in activated human neutrophils mediated by protein kinase C and a Ca2+-requiring proteinase.

1986 • 114 citations

Macrophage accumulation in mice is inhibited by low molecular weight products from murine leukemia viruses.

1980 • 110 citations

Modulation of Ca2+-activated, phospholipid-dependent protein kinase in platelets treated with a tumor-promoting phorbol ester

1984 • 109 citations

Inhibition of human natural killer cell activity by a synthetic peptide homologous to a conserved region in the retroviral protein, p15E.

1987 • 106 citations

A synthetic peptide homologous to the envelope proteins of retroviruses inhibits monocyte-mediated killing by inactivating interleukin 1.

1987 • 102 citations

The mechanism of retrovirus suppression of human T cell proliferation in vitro.

1983 • 101 citations

Tumor promoters in conjunction with calcium ionophores mimic antigenic stimulation by reactivation of alloantigen-primed murine T lymphocytes.

1985 • 83 citations

Suppression of the respiratory burst of human monocytes by a synthetic peptide homologous to envelope proteins of human and animal retroviruses.

1986 • 82 citations

Synthetic peptides homologous to HIV transmembrane glycoprotein suppress normal human lymphocyte blastogenic response

1988 • 70 citations

Intracellular activation of protein kinase C and regulation of the surface transferrin receptor by diacylglycerol is a spontaneously reversible process that is associated with rapid formation of phosphatidic acid.

1986 • 70 citations

Redistribution of protein kinase C during mitogenesis of human B lymphocytes

1986 • 68 citations

Inhibition of concanavalin A stimulation of feline lymphocytes by inactivated feline leukemia virus.

1977 • 64 citations

Protein kinase C desensitization by phorbol esters and its impact on growth of human breast cancer cells

1986 • 62 citations

Human retrovirus-related synthetic peptides inhibit T lymphocyte proliferation

1988 • 59 citations

Suppressive effect on polyclonal B-cell activation of a synthetic peptide homologous to a transmembrane component of oncogenic retroviruses.

1987 • 58 citations

Inhibition of human lymphocyte mitogen and antigen response by a 15,000-dalton protein from feline leukemia virus.

1979 • 54 citations

Inhibition of protein kinase C and anti-CD3-induced Ca2+ influx in Jurkat T cells by a synthetic peptide with sequence identity to HIV-1 gp41.

1990 • 46 citations

Human IFN-gamma production is inhibited by a synthetic peptide homologous to retroviral envelope protein.

1988 • 43 citations

Effect of phospholipid on substrate phosphorylation by a catalytic fragment of protein kinase C.

1987 • 40 citations

Inhibition of antibodies to CD3 surface antigen and phytohemagglutinin-mediated T cellular responses by inhibiting Ca2+/phospholipid-dependent protein kinase activity with the aid of 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine dihydrochloride.

1987 • 38 citations

Synthetic peptide corresponding to a conserved domain of the retroviral protein p15E blocks IL-1-mediated signal transduction.

1989 • 33 citations

Inhibition of murine cytotoxic T lymphocyte activity by a synthetic retroviral peptide and abrogation of this activity by IL.

1990 • 21 citations

Leukemia virus-induced immunosuppression. 8. Rapid depression of in vitro leukocyte migration after infection of mice with Friend leukemia virus.

1971 • 19 citations

LEUKEMIA VIRUS‐INDUCED IMMUNOSUPPRESSION: REVERSAL BY SUBCELLULAR FACTORS*

1979 • 18 citations