Human uracil–DNA glycosylase deficiency associated with profoundly impaired immunoglobulin class-switch recombination

Class Switch Recombination and Hypermutation Require Activation-Induced Cytidine Deaminase (AID), a Potential RNA Editing Enzyme

2000 • 3,323 citations

Activation-Induced Cytidine Deaminase (AID) Deficiency Causes the Autosomal Recessive Form of the Hyper-IgM Syndrome (HIGM2)

2000 • 1,604 citations

Specific Expression of Activation-induced Cytidine Deaminase (AID), a Novel Member of the RNA-editing Deaminase Family in Germinal Center B Cells

1999 • 1,149 citations

The immune responses in CD40-deficient mice: Impaired immunoglobulin class switching and germinal center formation

1994 • 1,099 citations

AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification

2002 • 879 citations

The CD40 ligand, gp39, is defective in activated T cells from patients with X-linked hyper-IgM syndrome

1993 • 840 citations

CD40 Ligand Gene Defects Responsible for X-Linked Hyper-IgM Syndrome

1993 • 836 citations

Mice deficient for the CD40 ligand

1994 • 753 citations

Defective expression of T-cell CD40 ligand causes X-linked immunodeficiency with hyper-IgM

1993 • 739 citations

Transcription-targeted DNA deamination by the AID antibody diversification enzyme

2003 • 723 citations

CD40 ligand mutations in X-linked immunodeficiency with hyper-IgM

1993 • 719 citations

R-loops at immunoglobulin class switch regions in the chromosomes of stimulated B cells

2003 • 712 citations

Immunoglobulin Isotype Switching Is Inhibited and Somatic Hypermutation Perturbed in UNG-Deficient Mice

2002 • 701 citations

Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase

2003 • 662 citations

The thymine glycosylase MBD4 can bind to the product of deamination at methylated CpG sites

1999 • 624 citations

Molecular Mechanism of Class Switch Recombination: Linkage with Somatic Hypermutation

2002 • 583 citations

Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase

2002 • 574 citations

AID is required to initiate Nbs1/γ-H2AX focus formation and mutations at sites of class switching

2001 • 496 citations

Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strand

2003 • 428 citations

Mechanism and control of class-switch recombination

2002 • 379 citations

Mutations ofCD40gene cause an autosomal recessive form of immunodeficiency with hyper IgM

2001 • 379 citations

Nuclear and mitochondrial uracil-DNA glycosylases are generated by alternative splicing and transcription from different positions in the UNG gene

1997 • 301 citations

Cell-cycle-regulated DNA double-strand breaks in somatic hypermutation of immunoglobulin genes

2000 • 264 citations

Properties of a Recombinant Human Uracil-DNA Glycosylase from the UNG Gene and Evidence that UNG Encodes the Major Uracil-DNA Glycosylase

1995 • 259 citations

Cloning and Expression of Human G/T Mismatch-specific Thymine-DNA Glycosylase

1996 • 255 citations

CD40-deficient mice generated by recombination-activating gene-2-deficient blastocyst complementation.

1994 • 245 citations

Neurofibromatosis and early onset of cancers in hMLH1-deficient children.

1999 • 238 citations

Deficiency in Msh2 affects the efficiency and local sequence specificity of immunoglobulin class-switch recombination: parallels with somatic hypermutation

1999 • 219 citations

Reduced Isotype Switching in Splenic B Cells from Mice Deficient in Mismatch Repair Enzymes

1999 • 218 citations

The influence of transcriptional orientation on endogenous switch region function

2003 • 208 citations

Excision of deaminated cytosine from the vertebrate genome: role of the SMUG1 uracil-DNA glycosylase

2001 • 194 citations

Linking class-switch recombination with somatic hypermutation

2001 • 156 citations

DNA Double-Strand Breaks

2002 • 151 citations

A homozygous germ-line mutation in the human MSH2 gene predisposes to hematological malignancy and multiple café-au-lait spots.

2002 • 142 citations

Hyper-IgM syndrome type 4 with a B lymphocyte–intrinsic selective deficiency in Ig class-switch recombination

2003 • 127 citations

Ig Sgamma3 DNA-specifc double strand breaks are induced in mitogen-activated B cells and are implicated in switch recombination.

1997 • 122 citations

Nuclear and mitochondrial splice forms of human uracil-DNA glycosylase contain a complex nuclear localisation signal and a strong classical mitochondrial localisation signal, respectively

1998 • 115 citations

De novoprotein synthesis is required for the activation-induced cytidine deaminase function in class-switch recombination

2003 • 112 citations

Abnormal CD40-mediated activation pathway in B lymphocytes from patients with hyper-IgM syndrome and normal CD40 ligand expression.

1997 • 89 citations

Extensive somatic microsatellite mutations in normal human tissue.

2001 • 85 citations

Isolation and characterization of a human cDNA encoding uracil-DNA glycosylase

1991 • 50 citations

Cell cycle regulation of a human cyclin-like gene encoding uracil-DNA glycosylase.

1993 • 48 citations

Cutting Edge: The G-U Mismatch Glycosylase Methyl-CpG Binding Domain 4 Is Dispensable for Somatic Hypermutation and Class Switch Recombination

2003 • 44 citations

Hyper-IgM syndromes: a model for studying the regulation of class switch recombination and somatic hypermutation generation

2002 • 43 citations

Sequence variation in the human uracil-DNA glycosylase (UNG) gene

2001 • 23 citations