Catalytic mechanism of NADP+-dependent isocitrate dehydrogenase: implications from the structures of magnesium-isocitrate and NADP+ complexes

<scp>CHARMM</scp>: A program for macromolecular energy, minimization, and dynamics calculations

1983 • 14,615 citations

The Anatomy and Taxonomy of Protein Structure

1981 • 3,376 citations

Crystallographic R Factor Refinement by Molecular Dynamics

1987 • 1,982 citations

Chemical and biological evolution of a nucleotide-binding protein

1974 • 1,457 citations

Interactive computer graphics: FRODO

1985 • 848 citations

Redesign of the coenzyme specificity of a dehydrogenase by protein engineering

1990 • 727 citations

The use of an imaging proportional counter in macromolecular crystallography

1987 • 494 citations

Interaction of pyrophosphate moieties with .alpha.-helixes in dinucleotide-binding proteins

1985 • 475 citations

Inactivation of isocitrate dehydrogenase by phosphorylation is mediated by the negative charge of the phosphate.

1987 • 300 citations

Regulation of an Enzyme by Phosphorylation at the Active Site

1990 • 246 citations

Structure of Lactate Dehydrogenase at 2.8 Å Resolution

1970 • 234 citations

High guanine plus cytosine content in the third letter of codons of an extreme thermophile. DNA sequence of the isopropylmalate dehydrogenase of Thermus thermophilus.

1984 • 207 citations

Structure of a bacterial enzyme regulated by phosphorylation, isocitrate dehydrogenase.

1989 • 205 citations

Site-directed mutagenesis reveals role of mobile arginine residue in lactate dehydrogenase catalysis

1986 • 179 citations

On the importance of orientation in general base catalysis by carboxylate

1981 • 172 citations

The NADPH binding site on beef liver catalase.

1985 • 170 citations

Metal Ion-catalyzed Decarboxylation: A Model for an Enzyme System¹

1951 • 149 citations

Electrostatic and Steric Contributions to Regulation at the Active Site of Isocitrate Dehydrogenase

1990 • 118 citations

THE ENZYMATIC PROPERTIES OF ISOCITRIC DEHYDROGENASE

1957 • 105 citations

The mechanisms of reductive carboxylation reactions. Carbon dioxide or bicarbonate as substrate of nicotinamide-adenine dinucleotide phosphate-linked isocitrate dehydrogenase and ‘malic’ enzyme

1968 • 97 citations

Isolation, nucleotide sequence, and disruption of the Saccharomyces cerevisiae gene encoding mitochondrial NADP(H)-specific isocitrate dehydrogenase

1991 • 89 citations

The Enzymatic Transfer of Hydrogen

1960 • 87 citations

Structure of the medium-chain acyl-CoA dehydrogenase from pig liver mitochondria at 3-A resolution.

1988 • 77 citations

Phosphorylation Inactivates Escherichia coli Isocitrate Dehydrogenase by Preventing Isocitrate Binding

1989 • 73 citations

The Stereochemistry of Decarboxylation of Isocitrate by Isocitric Acid Dehydrogenase^*

1964 • 66 citations

The equilibrium constant of the isocitrate dehydrogenase reaction

1968 • 64 citations

Structure and Properties of Malic Enzyme from Bacillus stearothermophilus

1989 • 60 citations

Structure and expression of murine malic enzyme mRNA. Differentiation-dependent accumulation of two forms of malic enzyme mRNA in 3T3-L1 cells.

1987 • 52 citations

X-ray study of the lithium complex of NAD+

1977 • 51 citations

Isotope Effects in the Enzymatic Decarboxylation of Oxalacetic Acid

1959 • 46 citations

Isotope effect studies of the chemical mechanism of pig heart NADP isocitrate dehydrogenase

1988 • 40 citations

The three dimensional structure of sheep liver 6-phosphogluconate dehydrogenase at 2.6 A resolution.

1983 • 29 citations

Proton nuclear magnetic resonance studies of the conformation and environment of nucleotides bound to pig heart NADP+-dependent isocitrate dehydrogenase

1985 • 26 citations

Role of metal ions in reaction catalyzed by pig heart triphosphopyridine nucleotide-dependent isocitrate dehydrogenase. III. Frequency and temperature dependence of the proton relaxation rates of solvent and substrate interaction with isocitrate dehydrogenase-bound manganese(II)

1974 • 24 citations

Ionization of isocitrate bound to pig heart NADP+-dependent isocitrate dehydrogenase: 13C NMR study of substrate binding

1987 • 20 citations

Stereochemistry of the decarboxylation reaction catalysed by 3-isopropylmalate dehydrogenase from the thermophilic bacterium Thermus thermophilus

1989 • 16 citations

Studies of the phosphorylation of Escherichia coli isocitrate dehydrogenase. Recognition of the enzyme by isocitrate dehydrogenase kinase/phosphatase and effects of phosphorylation on its structure and properties

1989 • 13 citations

X-ray crystal analysis of the substrates of aconitase. VIII. The structure and absolute configuration of potassium dihydrogen isocitrate isolated from Bryophyllum calycinum

1968 • 11 citations

Multinuclear NMR studies of the divalent metal binding site of NADP-dependent isocitrate dehydrogenase from pig heart

1989 • 11 citations