Angiotensin II-mediated expression of p27Kip1 and induction of cellular hypertrophy in renal tubular cells depend on the generation of oxygen radicals

Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation. Contribution to alterations of vasomotor tone.

1996 • 2,456 citations

Role of the Ubiquitin-Proteasome Pathway in Regulating Abundance of the Cyclin-Dependent Kinase Inhibitor p27

1995 • 1,848 citations

Mitogenic Signaling Mediated by Oxidants in Ras-Transformed Fibroblasts

1997 • 1,582 citations

Superoxide Anion Radical (O·̄2), Superoxide Dismutases, and Related Matters

1997 • 1,281 citations

Tubulointerstitial Changes as a Major Determinant in the Progression of Renal Damage

1992 • 951 citations

Role of Superoxide in Angiotensin II–Induced but Not Catecholamine-Induced Hypertension

1997 • 831 citations

p22 Is a Critical Component of the Superoxide-generating NADH/NADPH Oxidase System and Regulates Angiotensin IIinduced Hypertrophy in Vascular Smooth Muscle Cells

1996 • 768 citations

Does superoxide underlie the pathogenesis of hypertension?

1991 • 760 citations

Phosphorylation-dependent degradation of the cyclin-dependent kinase inhibitor p27Kip1

1997 • 698 citations

Active oxygen species stimulate vascular smooth muscle cell growth and proto-oncogene expression.

1992 • 653 citations

The origin and characteristics of a pig kidney cell strain, LLC-PK1

1976 • 604 citations

p22phox mRNA Expression and NADPH Oxidase Activity Are Increased in Aortas From Hypertensive Rats

1997 • 555 citations

Validation of Lucigenin (Bis-N-methylacridinium) as a Chemilumigenic Probe for Detecting Superoxide Anion Radical Production by Enzymatic and Cellular Systems

1998 • 526 citations

Mechanisms of ischemic acute renal failure

1993 • 523 citations

Angiotensin II-induced hypertrophy of cultured murine proximal tubular cells is mediated by endogenous transforming growth factor-beta.

1993 • 381 citations

Characterization of a renal tubular epithelial cell line which secretes the autologous target antigen of autoimmune experimental interstitial nephritis.

1988 • 311 citations

Role of reactive oxygen metabolites in experimental glomerular disease

1989 • 276 citations

Reactive oxygen species: production and role in the kidney

1986 • 267 citations

Angiotensin II induces cellular hypertrophy in cultured murine proximal tubular cells

1990 • 211 citations

Superoxide anion formation from lucigenin: an electron spin resonance spin‐trapping study

1997 • 192 citations

The p53-independent activation of transcription of p21 WAF1/CIP1/SDI1 after acute renal failure

1996 • 152 citations

Functional expression of NADPH oxidase components (alpha- and beta-subunits of cytochrome b558 and 45-kDa flavoprotein) by intrinsic human glomerular mesangial cells.

1991 • 146 citations

Hydrogen peroxide-induced c-fos expression is mediated by arachidonic acid release: role of protein kinase C

1993 • 137 citations

NAD(P)H oxidase activity in cultured human podocytes: Effects of adenosine triphosphate

1998 • 133 citations

Induction of renal growth and injury in the intact rat kidney by dietary deficiency of antioxidants.

1990 • 128 citations

Hydrogen peroxide stimulates transcription of c-jun in vascular smooth muscle cells: role of arachidonic acid.

1993 • 123 citations

Molecular mechanisms of tubulointerstitial hypertrophy and hyperplasia

1991 • 111 citations

Redox regulation of renal DNA synthesis, transforming growth factor-β1 and collagen gene expression

1998 • 111 citations

Cytochrome b-558 α-subunit cloning and expression in rat aortic smooth muscle cells

1995 • 110 citations

The Role of Reactive Oxygen Species in Animal Models of Glomerular Disease

1992 • 97 citations

Cell-cycle control and renal disease

1997 • 97 citations

NADH/NADPH Oxidase and Vascular Function

1997 • 97 citations

Altered Regulation of G1 Cyclins in Oxidant-induced Growth Arrest of Lung Alveolar Epithelial Cells

1996 • 86 citations

Intracellular signaling of transcription and secretion of type IV collagen after angiotensin II-induced cellular hypertrophy in cultured proximal tubular cells.

1991 • 77 citations

Induction of p21 Mediated by Reactive Oxygen Species Formed during the Metabolism of Aziridinylbenzoquinones by HCT116 Cells

1996 • 70 citations

Controlling cell proliferation in differentiating tissues: genetic analysis of negative regulators of G1→S-phase progression

1997 • 63 citations

Angiotensin II-stimulated hypertrophy of LLC-PK1 cells depends on the induction of the cyclin-dependent kinase inhibitor p27Kip1

1996 • 58 citations

Angiotensin II stimulates cellular hypertrophy of LLC-PK<sub>1</sub> cells through the AT<sub>1</sub> receptor

1993 • 45 citations

p21 Is a Component of Active Cell Cycle Kinases

1994 • 36 citations

Selective antagonism of the AT1 receptor inhibits angiotensin II stimulated DNA and protein synthesis in primary cultures of human proximal tubular cells

1997 • 28 citations

Regulation of S6 kinase activity in renal proximal tubule

1992 • 27 citations

Oxidative stress and vascular injury-relevant for atherogenesis in uraemic patients?

1997 • 21 citations

Selective antagonism of the AT1 receptor inhibits the effect of angiotensin II on DNA and protein synthesis of rat proximal tubular cells.

1997 • 15 citations

Proliferation of Mouse Fibroblasts Induced by 1,2-Dimethylhydrazine Auto-Oxidation: Role of Iron and Free Radicals

1997 • 14 citations

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