A mutation in Saccharomyces cerevisiae adenylate cyclase, Cyr1^K1876M, specifically affects glucose‐ and acidification‐induced cAMP signalling and not the basal cAMP level

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mpl8 and pUC19 vectors

1985 • 15,222 citations

Methods in yeast genetics

1979 • 7,824 citations

A highly sensitive adenylate cyclase assay

1974 • 4,213 citations

New yeast-Escherichia coli shuttle vectors constructed with in vitro mutagenized yeast genes lacking six-base pair restriction sites

1988 • 2,903 citations

Elevated recombination rates in transcriptionally active DNA

1989 • 1,666 citations

In yeast, RAS proteins are controlling elements of adenylate cyclase

1985 • 1,142 citations

Transformation in yeast: Development of a hybrid cloning vector and isolation of the can1 gene

1979 • 1,080 citations

Purification of a RAS-responsive adenylyl cyclase complex from Saccharomyces cerevisiae by use of an epitope addition method.

1988 • 983 citations

Reserve carbohydrate metabolism in Saccharomyces cerevisiae: responses to nutrient limitation

1980 • 807 citations

Three different genes in S. cerevisiae encode the catalytic subunits of the cAMP-dependent protein kinase

1987 • 703 citations

Cloning and characterization of BCY1, a locus encoding a regulatory subunit of the cyclic AMP-dependent protein kinase in Saccharomyces cerevisiae.

1987 • 504 citations

DNA sequence and characterization of the S. cerevisiae gene encoding adenylate cyclase

1985 • 429 citations

Stress signaling in yeast

1995 • 415 citations

Signal transduction in yeast

1994 • 385 citations

A Saccharomyces cerevisiae G‐protein coupled receptor, Gpr1, is specifically required for glucose activation of the cAMP pathway during the transition to growth on glucose

1999 • 350 citations

Involvement of distinct G-proteins, Gpa2 and Ras, in glucose-and intracellular acidification-induced cAMP signalling in the yeast Saccharomyces cerevisiae

1998 • 311 citations

IRA2, a second gene of Saccharomyces cerevisiae that encodes a protein with a domain homologous to mammalian ras GTPase-activating protein.

1990 • 305 citations

GPR1 encodes a putative G protein-coupled receptor that associates with the Gpa2p Gα subunit and functions in a Ras-independent pathway

1998 • 302 citations

IRA1, an inhibitory regulator of the RAS-cyclic AMP pathway in Saccharomyces cerevisiae.

1989 • 251 citations

Characterization, cloning and sequence analysis of the CDC25 gene which controls the cyclic AMP level of Saccharomyces cerevisiae.

1986 • 232 citations

Rigorous feedback control of cAMP levels in Saccharomyces cerevisiae.

1987 • 230 citations

The Function of Ras Genes in Saccharomyces Cerevisiae

1990 • 218 citations

Cyclic 3′,5′-adenosine monophosphate stimulates trehalose degradation in baker's yeast

1974 • 211 citations

Isolation of a second yeast Saccharomyces cerevisiae gene (GPA2) coding for guanine nucleotide-binding regulatory protein: studies on its structure and possible functions.

1988 • 206 citations

Evidence that sorbic acid does not inhibit yeast as a classic ‘weak acid preservative’

1998 • 202 citations

ThePDE1-encoded Low-Affinity Phosphodiesterase in the YeastSaccharomyces cerevisiaeHas a Specific Function in Controlling Agonist-induced cAMP Signaling

1999 • 195 citations

Fermentable sugars and intracellular acidification as specific activators of the RAS‐adenylate cyclase signalling pathway in yeast: the relationship to nutrient‐induced cell cycle control

1991 • 173 citations

Genetic and biochemical evidence that trehalase is a substrate of cAMP-dependent protein kinase in yeast.

1983 • 158 citations

Regulation of fructose-1,6-bisphosphatase in yeast by phosphorylation/dephosphorylation

1981 • 144 citations

The RAS-adenylate cyclase pathway and cell cycle control inSaccharomyces cerevisiae

1992 • 138 citations

Glucose Derepression of Gluconeogenic Enzymes in Saccharomyces cerevisiae Correlates with Phosphorylation of the Gene Activator Cat8p

1997 • 123 citations

Adenylate cyclases in yeast: a comparison of the genes from Schizosaccharomyces pombe and Saccharomyces cerevisiae.

1989 • 118 citations

Requirement of One Functional RAS Gene and Inability of an Oncogenic ras Variant to Mediate the Glucose-Induced Cyclic AMP Signal in the Yeast Saccharomyces cerevisiae

1988 • 115 citations

The Sch9 protein kinase in the yeast Saccharomyces cerevisiae controls cAPK activity and is required for nitrogen activation of the fermentable-growth-medium-induced (FGM) pathway

1997 • 115 citations

Negative regulation of transcription of the Saccharomyces cerevisiae catalase T (CTT1) gene by cAMP is mediated by a positive control element.

1991 • 108 citations

Glucose-Induced Hyperaccumulation of Cyclic AMP and Defective Glucose Repression in Yeast Strains with Reduced Activity of Cyclic AMP-Dependent Protein Kinase

1990 • 105 citations

Regulation of the cAMP Level in the Yeast Saccharomyces cerevisiae: Intracellular pH and the Effect of Membrane Depolarizing Compounds

1987 • 104 citations

Regulation of trehalase activity by phosphorylation-dephosphorylation during developmental transitions in fungi

1988 • 101 citations

Identification of the structural gene and nonsense alleles for adenylate cyclase in Saccharomyces cerevisiae

1984 • 101 citations

Suppression of defective RAS1 and RAS2 functions in yeast by an adenylate cyclase activated by a single amino acid change.

1986 • 93 citations

Nutrient-induced activation of trehalase in nutrient-starved cells of the yeast Saccharomyces cerevisiae: cAMP is not involved as second messenger

1992 • 93 citations

Phylogeny of adenylyl cyclases.

1993 • 85 citations

Requirement of one functional RAS gene and inability of an oncogenic ras variant to mediate the glucose-induced cyclic AMP signal in the yeast Saccharomyces cerevisiae.

1988 • 80 citations

Glucose-triggered signalling in Saccharomyces cerevisiae: different requirements for sugar phosphorylation between cells grown on glucose and those grown on non-fermentable carbon sources

1996 • 79 citations

Glucose-induced hyperaccumulation of cyclic AMP and defective glucose repression in yeast strains with reduced activity of cyclic AMP-dependent protein kinase.

1990 • 77 citations

Regulation of the cAMP Level in the Yeast Saccharomyces cerevisiae: the Glucose-induced cAMP Signal Is Not Mediated by a Transient Drop in the Intracellular pH

1987 • 74 citations

Phosphorylation of yeast phosphatidylserine synthase in vivo and in vitro by cyclic AMP-dependent protein kinase.

1988 • 72 citations

Activation of trehalase during growth induction by nitrogen sources in the yeast Saccharomyces cerevisiae depends on the free catalytic subunits of camp‐dependent protein kinase, but not on functional ras proteins

1994 • 62 citations

Glucose‐stimulated cAMP increase may be mediated by intracellular acidification in Saccharomyces cerevisiae

1985 • 61 citations

Mechanism of Regulation in Yeast Glycogen Phosphorylase

1995 • 57 citations

Multistress resistance of Saccharomyces cerevisiae is generated by insertion of retrotransposon Ty into the 5' coding region of the adenylate cyclase gene.

1988 • 57 citations

Quantification of trehalose in biological samples with a conidial trehalase from the thermophilic fungus Humicola grisea var. thermoidea

1994 • 51 citations

An Adenylate Cyclase from Saccharomyces cerevisiae That Is Stimulated by RAS Proteins with Effector Mutations

1988 • 50 citations

RAS Genes in the Budding Yeast Saccharomyces cerevisiae

1993 • 39 citations

Solubilization and other studies on adenylate cyclase of baker's yeast

1976 • 37 citations

Absence of glucose-induced cAMP signaling in the Saccharomyces cerevisiae mutants cat1 and cat3 which are deficient in derepression of glucose-repressible proteins

1990 • 36 citations

Identification of the domain of Saccharomyces cerevisiae adenylate cyclase associated with the regulatory function of RAS products

1987 • 35 citations

The metabolism of storage carbohydrates in yeast, studied with glucose-1-C14 and dinitrophenol

1957 • 32 citations

The lag phase rather than the exponential-growth phase on glucose is associated with a higher cAMP level in wild-type and cAPK-attenuated strains of the yeast Saccharomyces cerevisiae

1997 • 30 citations

Adenylyl cyclase in yeast. Hydrodynamic properties and activation by trypsin.

1987 • 30 citations

An adenylate cyclase from Saccharomyces cerevisiae that is stimulated by RAS proteins with effector mutations.

1988 • 27 citations

Identification of regulatory residues of the yeast adenylyl cyclase.

1991 • 22 citations

[47] Yeast adenylyl cyclase assays

1995 • 10 citations

A TY1 element is inserted in the CYR1 control region of Saccharomyces cerevisiae strain AB320

1987 • 4 citations