Evaluation of antitumor drug side effects in small animals

Principles and procedures of statistics.

1960 • 22,587 citations

Quantitative comparison of toxicity of anticancer agents in mouse, rat, hamster, dog, monkey, and man.

1966 • 1,363 citations

Tables for Convenient Calculation of Median-Effective Dose (LD 50 or ED 50 ) and Instructions in Their Use

1952 • 1,061 citations

Adaptation of Orbital Bleeding Technic to Rapid Serial Blood Studies

1960 • 457 citations

Quantitative prediction of drug toxicity in humans from toxicology in small and large animals.

1975 • 132 citations

Brief Communication : Adriamycin-Induced Cardiac Damage in the Mouse: A Small-Animal Model of Cardiotoxicity

1975 • 110 citations

Acute toxicologic and pathologic effects of cis-diamminedichloroplatinum (NSC-119875) in the male rat.

1971 • 106 citations

Subacute cardiotoxicity of adriamycin in the rat: biochemical and ultrastructural investigations.

1977 • 91 citations

Chlorozotocin, 2-(3-(2-chloroethyl)-3-nitrosoureido)-D-glucopyranose, an antitumor agent with modified bone marrow toxicity.

1975 • 73 citations

Adaptation of orbital bleeding technic to rapid serial blood studies.

1960 • 64 citations

New Manual and Automated Method for Determining Activity of Creatine Kinase Isoenzyme MB, by Use of Dithiothreitol: Clinical Applications

1975 • 42 citations

Preclinical toxicologic evaluation of bleomycin (NSC 125 066), a new antitumor antibiotic*1, *2

1972 • 33 citations

Hematology and clinical chemistry reference values for C57BL/6 X DBA/2 F1 mice.

1978 • 30 citations

Adequacies and inadequacies in assessing murine toxicity data with antineoplastic agents.

1979 • 27 citations

Toxicologic and pharmacologic evaluation of phleomycin including special studies on its nephrotoxicity

1969 • 12 citations

Delayed toxicity of 4'-demethylepipodophyllotoxin 9-(4,6-O-2-thenylidene-beta-D-glucopyranoside) (NSC-122819; VM-26) in mice.

1973 • 9 citations