Non-isotopic in situ detection of mRNA for interleukin-4 in archival human tissue

The use of avidin-biotin interaction in immunoenzymatic techniques.

1979 • 1,734 citations

Enzymatic synthesis of biotin-labeled polynucleotides: novel nucleic acid affinity probes.

1981 • 1,165 citations

Detection of interleukin-5 messenger RNA in Reed-Sternberg cells of Hodgkin's disease with eosinophilia

1990 • 220 citations

In vivo cytokine gene expression in T cell subsets of the autoimmune MRL/Mp‐lpr/lpr mouse

1990 • 219 citations

Molecular cloning of rat interleukin 4 cDNA and analysis of the cytokine repertoire of subsets of CD4⁺ T cells

1991 • 218 citations

Non-radioactive labeling of RNA transcriptsin vitrowith the hapten digoxigenin (DIG); hybridization and ELISA-based detection

1990 • 200 citations

Macrophages in human breast disease: a quantitative immunohistochemical study

1988 • 160 citations

Restricted production of interleukin 4 by activated human T cells.

1988 • 141 citations

Detection of low copy human papilloma virus DNA and mRNA in routine paraffin sections of cervix by non-isotopic in situ hybridisation.

1987 • 134 citations

Macrophage infiltration of breast tumours: a prospective study.

1977 • 110 citations

DIFFERENTIAL IN SITU EXPRESSION OF CYTOKINES IN RENAL ALLOGRAFT REJECTION

1991 • 102 citations

Interphase cytogenetics using biotin and digoxigenin labelled probes I: relative sensitivity of both reporter molecules for detection of HPV16 in CaSki cells.

1989 • 87 citations

Interphase cytogenetics using biotin and digoxigenin labelled probes: III. Increased sensitivity and flexibility for detecting HPV in cervical biopsy specimens and cell lines.

1991 • 64 citations

Human CD4⁺CD45RO⁺ and CD4⁺CD45RA⁺ T cells synergize in response to alloantigens

1991 • 41 citations

Peripheral blood lymphocytes from patients with cancer lack interleukin-2 receptors

1988 • 30 citations

Degree of biotinylation in nucleic acids estimated by a gel retardation assay

1989 • 29 citations

Model system for optimising mRNA non-isotopic in situ hybridisation: riboprobe detection of lysozyme mRNA in archival gut biopsy specimens.

1991 • 25 citations

Measurement of cytokine release by human cells A quantitative analysis at the single cell level using the reverse haemolytic plaque assay

1990 • 18 citations

In situ hybridization of the mRNA for interferon-γ, interferon-αE, interferon-β, interleukin-1β and interleukin-6 and characterization of infiltrating cells in thyroid tissues

1992 • 16 citations

Cytokines: A practical approach

1992 • 12 citations

Differential regulation of lymphokine production in mitogen‐stimulated murine spleen cells

1991 • 10 citations

Gastrointestinal pathology

1990 • 5 citations