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The innate and early immune response to pathogen challenge in the female genital tract and the pivotal role of epithelial cells

Data up to Jan 2025

Published2002
Citations279
References87

Total Citations Per Year

Abstract

References (87)

CD14, a Receptor for Complexes of Lipopolysaccharide (LPS) and LPS Binding Protein

1990 • 4,041 citations

The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between Toll-like receptors

2000 • 2,076 citations

Toll-like Receptor-4 Mediates Lipopolysaccharide-induced Signal Transduction

1999 • 1,905 citations

β-Defensins: Linking Innate and Adaptive Immunity Through Dendritic and T Cell CCR6

1999 • 1,760 citations

Innate immunity: impact on the adaptive immune response

1997 • 1,542 citations

NO at work

1994 • 1,493 citations

A distinct array of proinflammatory cytokines is expressed in human colon epithelial cells in response to bacterial invasion.

1995 • 1,205 citations

Regulation of Intestinal α-Defensin Activation by the Metalloproteinase Matrilysin in Innate Host Defense

1999 • 1,069 citations

Defensins: Antimicrobial and Cytotoxic Peptides of Mammalian Cells

1993 • 986 citations

Lipopolysaccharide activation of human endothelial and epithelial cells is mediated by lipopolysaccharide-binding protein and soluble CD14.

1993 • 845 citations

Prokaryotic Regulation of Epithelial Responses by Inhibition of IκB-α Ubiquitination

2000 • 837 citations

Lipopolysaccharide Activates Distinct Signaling Pathways in Intestinal Epithelial Cell Lines Expressing Toll-Like Receptors

2000 • 754 citations

Human beta-defensin-1: an antimicrobial peptide of urogenital tissues.

1998 • 733 citations

Sexually transmitted diseases

1999 • 723 citations

Epithelial cells secrete the chemokine interleukin-8 in response to bacterial entry

1993 • 663 citations

Epithelial cells as sensors for microbial infection.

1997 • 623 citations

Widespread expression of beta‐defensin hBD‐1 in human secretory glands and epithelial cells

1996 • 571 citations

Direct inactivation of viruses by human granulocyte defensins

1986 • 525 citations

Paneth cells of the human small intestine express an antimicrobial peptide gene

1992 • 525 citations

Simian Immunodeficiency Virus Rapidly Penetrates the Cervicovaginal Mucosa after Intravaginal Inoculation and Infects Intraepithelial Dendritic Cells

2000 • 522 citations

Sexually Transmitted Diseases

1990 • 510 citations

Secretion of proinflammatory cytokines by epithelial cells in response to Chlamydia infection suggests a central role for epithelial cells in chlamydial pathogenesis.

1997 • 510 citations

A Controlled Trial of Nonoxynol 9 Film to Reduce Male-to-Female Transmission of Sexually Transmitted Diseases

1998 • 383 citations

The prime-boost strategy: exciting prospects for improved vaccination

2000 • 373 citations

NF-kappa B is a central regulator of the intestinal epithelial cell innate immune response induced by infection with enteroinvasive bacteria.

1999 • 334 citations

Gene expression, immunolocalization, and secretion of human defensin-5 in human female reproductive tract.

1998 • 321 citations

CD14-dependent Lipopolysaccharide-induced β-Defensin-2 Expression in Human Tracheobronchial Epithelium

2000 • 309 citations

Distribution of Poliovirus Antibody in Serum, Nasopharynx and Alimentary Tract Following Segmental Immunization of Lower Alimentary Tract with Poliovaccine

1969 • 272 citations

NF-κB Is a Central Regulator of the Intestinal Epithelial Cell Innate Immune Response Induced by Infection with Enteroinvasive Bacteria

1999 • 272 citations

Structure and mapping of the human β-defensin HBD-2 gene and its expression at sites of inflammation

1998 • 257 citations

Developmental regulation of cryptdin, a corticostatin/defensin precursor mRNA in mouse small intestinal crypt epithelium.

1989 • 254 citations

Transforming growth factor β—a mediator of immune deviation in seminal plasma

2002 • 253 citations

Induction of specific immunoglobulin A in the small intestine, colon-rectum, and vagina measured by a new method for collection of secretions from local mucosal surfaces

1994 • 250 citations

Safety Study of Nonoxynol-9 as a Vaginal Microbicide: Evidence of Adverse Effects

1998 • 247 citations

Evidence for an acute phase response in human intestinal epithelial cells

1993 • 245 citations

Response toNeisseria gonorrhoeaeby Cervicovaginal Epithelial Cells Occurs in the Absence of Toll-Like Receptor 4-Mediated Signaling

2002 • 232 citations

Seminal Transforming Growth Factor β1, Stimulates Granulocyte-Macrophage Colony-Stimulating Factor Production and Inflammatory Cell Recruitment in the Murine Uterus1

1998 • 228 citations

The Human β-Defensin-1 and α-Defensins Are Encoded by Adjacent Genes: Two Peptide Families with Differing Disulfide Topology Share a Common Ancestry

1997 • 212 citations

Infectious Diseases of the Female Genital Tract

1991 • 208 citations

V. Innate mechanisms of mucosal defense and repair: the best offense is a good defense

1999 • 198 citations

Role of intestinal epithelial cells in the host secretory response to infection by invasive bacteria. Bacterial entry induces epithelial prostaglandin h synthase-2 expression and prostaglandin E2 and F2alpha production.

1997 • 194 citations

Differential Expression of Immunobiological Mediators by Immortalized Human Cervical and Vaginal Epithelial Cells1

1999 • 192 citations

Unique CD8+ T cell-rich lymphoid aggregates in human uterine endometrium

1997 • 187 citations

Highly polarized HLA class II antigen processing and presentation by human intestinal epithelial cells.

1998 • 186 citations

Posttranslational processing of defensins in immature human myeloid cells

1992 • 180 citations

Infection of human intestinal epithelial cells with invasive bacteria upregulates apical intercellular adhesion molecule-1 (ICAM)-1) expression and neutrophil adhesion.

1996 • 178 citations

Epithelial cell layer thickness and immune cell populations in the normal human vagina at different stages of the menstrual cycle

2000 • 178 citations

Leukocyte networks and human endometrial remodelling

2002 • 170 citations

Evidence for a common mucosal immunologic system. II. Influence of the estrous cycle on B immunoblast migration into genital and intestinal tissues.

1980 • 153 citations

Posttranslational processing of defensins in immature human myeloid cells

1992 • 152 citations

Enteroinvasive bacteria directly activate expression of iNOS and NO production in human colon epithelial cells

1998 • 152 citations

Distinct Proinflammatory Host Responses to Neisseria gonorrhoeae Infection in Immortalized Human Cervical and Vaginal Epithelial Cells

2001 • 151 citations

Human Reproduction: Conception and Contraception.

1974 • 147 citations

Mucus: The Front Line of Intestinal Mucosal Defense

1992 • 145 citations

Differential cytokine regulation of complement C3, C4, and factor B synthesis in human intestinal epithelial cell line, Caco-2.

1993 • 141 citations

Endotoxin-neutralizing capacity of soluble CD14

1992 • 137 citations

Presence of secretory leukocyte protease inhibitor in human endometrium and first trimester decidua suggests an antibacterial protective role

2000 • 130 citations

Regulation of Human β-Defensins by Gastric Epithelial Cells in Response to Infection withHelicobacter pylorior Stimulation with Interleukin-1

2000 • 120 citations

P fimbriae‐dependent, lipopolysaccharide‐independent activation of epithelial cytokine responses

1999 • 113 citations

Intestinal epithelial cells as watchdogs for the natural immune system

1995 • 111 citations

Control of the immunological environment of the uterus

2000 • 107 citations

Sex hormone and IL-6 regulation of antigen presentation in the female reproductive tract mucosal tissues.

1995 • 93 citations

Quantitative Analysis of T Lymphocyte Subsets in Pregnant and Nonpregnant Human Endometrium1

1996 • 88 citations

Comparison of Microbicides for Efficacy in Protecting Mice Against Vaginal Challenge With Herpes Simplex Virus Type 2, Cytotoxicity, Antibacterial Properties, and Sperm Immobilization

2001 • 86 citations

Antimicrobial activity of human cervical mucus

2000 • 79 citations

Anatomic sites of upper genital tract infection.

1985 • 79 citations

Chlamydia trachomatis Infection in the Female Reproductive Tract of the Rat: Influence of Progesterone on Infectivity and Immune Response

1998 • 73 citations

Routes of immunization and antigen delivery systems for optimal mucosal immune responses in humans.

1997 • 73 citations

Paneth cells—guardians of the gut cell hatchery

2000 • 70 citations

Immunoglobulins, proteinase inhibitors, albumin, and lysozyme in human cervical mucus

1977 • 68 citations

A cytokine switch induced by human seminal plasma: an immune modulation with implications for sexually transmitted disease

1997 • 62 citations

Immunosuppression by seminal prostaglandins.

1989 • 58 citations

Mucosal Vaccination Strategies for Women

1999 • 58 citations

Opsonic activity of MCP-1 and MCP-2, cationic peptides from rabbit alveolar macrophages

1985 • 53 citations

Differential Regulation of CD4 Lymphocyte Recruitment between the Upper and Lower Regions of the Genital Tract duringChlamydia trachomatisInfection

2000 • 52 citations

MHC class II expression and antigen presentation by human endometrial cells

2001 • 51 citations

Effect of live and heat-killed bacteria on the secretory activity of Paneth cells in germ-free mice

1988 • 48 citations

Antichlamydial activity of vaginal secretion

1995 • 42 citations

Immunophenotypic analysis of the transformation zone of human cervix.

1988 • 37 citations

Innate Humoral Factors

1994 • 35 citations

Human Reproduction: Conception and Contraception

1975 • 23 citations

Lysozyme in cervical mucus of patients with chorioamnionitis.

1993 • 17 citations

Control of the immunological environment of the uterus

2000 • 16 citations

Pelvic Inflammatory Disease

1993 • 15 citations

A Comparative Evaluation of Vaginal, Cervical and Peritoneal Flora in Normal, Healthy Women

1982 • 15 citations

Birth control vaccines.

1988 • 12 citations

Murine female reproductive tract intraepithelial lymphocytes display selection characteristics distinct from both peripheral and other mucosal T cells

2001 • 10 citations

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