Defective β-Adrenergic Receptor Signaling Precedes the Development of Dilated Cardiomyopathy in Transgenic Mice with Calsequestrin Overexpression

A Calcineurin-Dependent Transcriptional Pathway for Cardiac Hypertrophy

1998 • 2,570 citations

Wall stress and patterns of hypertrophy in the human left ventricle.

1975 • 2,343 citations

Altered expression of beta-adrenergic receptor kinase and beta 1-adrenergic receptors in the failing human heart.

1993 • 877 citations

MLP-Deficient Mice Exhibit a Disruption of Cardiac Cytoarchitectural Organization, Dilated Cardiomyopathy, and Heart Failure

1997 • 831 citations

Dilated Cardiomyopathy in Transgenic Mice With Cardiac-Specific Overexpression of Tumor Necrosis Factor-α

1997 • 830 citations

RETRACTED: Segregation of atrial-specific and inducible expression of an atrial natriuretic factor transgene in an in vivo murine model of cardiac hypertrophy.

1991 • 769 citations

Defective Excitation-Contraction Coupling in Experimental Cardiac Hypertrophy and Heart Failure

1997 • 754 citations

Cardiac Function in Mice Overexpressing the β-Adrenergic Receptor Kinase or a βARK Inhibitor

1995 • 714 citations

Complex Formation between Junctin, Triadin, Calsequestrin, and the Ryanodine Receptor

1997 • 516 citations

Expression of a β-adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene-targeted mice

1998 • 482 citations

Medical Therapy Can Improve the Biological Properties of the Chronically Failing Heart

1996 • 468 citations

Targeting the Receptor-G _q Interface to Inhibit in Vivo Pressure Overload Myocardial Hypertrophy

1998 • 457 citations

Targeted overexpression of protein kinase C β2 isoform in myocardium causes cardiomyopathy

1997 • 388 citations

Transcriptional Regulation During Cardiac Growth and Development

1993 • 371 citations

Growth Factors and Mitogen-Activated Protein Kinases

1998 • 329 citations

Expression of beta-arrestins and beta-adrenergic receptor kinases in the failing human heart.

1994 • 300 citations

Regulation of Ca2+ signaling in transgenic mouse cardiac myocytes overexpressing calsequestrin.

1998 • 282 citations

Mechanism of β-Adrenergic Receptor Desensitization in Cardiac Hypertrophy Is Increased β-Adrenergic Receptor Kinase

1997 • 257 citations

Dilated cardiomyopathy in transgenic mice expressing a dominant-negative CREB transcription factor in the heart.

1998 • 247 citations

Decompensation of Pressure-Overload Hypertrophy in Gαq-Overexpressing Mice

1998 • 204 citations

Cardiac-specific Overexpression of Mouse Cardiac Calsequestrin Is Associated with Depressed Cardiovascular Function and Hypertrophy in Transgenic Mice

1998 • 193 citations

Why does the myocardium fail? Insights from basic science

1998 • 177 citations

Enhanced Contractility and Decreased β-Adrenergic Receptor Kinase-1 in Mice Lacking Endogenous Norepinephrine and Epinephrine

1999 • 43 citations

Sarcoplasmic reticulum in heart failure: central player or bystander?

1998 • 37 citations