Sarcoplasmic reticulum in heart failure: central player or bystander?

Decreased Catecholamine Sensitivity and β-Adrenergic-Receptor Density in Failing Human Hearts

1982 • 2,259 citations

Calcium Sparks: Elementary Events Underlying Excitation-Contraction Coupling in Heart Muscle

1993 • 1,917 citations

Calcium-induced release of calcium from the cardiac sarcoplasmic reticulum

1983 • 1,884 citations

Abnormal intracellular calcium handling in myocardium from patients with end-stage heart failure.

1987 • 923 citations

Relation between myocardial function and expression of sarcoplasmic reticulum Ca(2+)-ATPase in failing and nonfailing human myocardium.

1994 • 769 citations

Defective Excitation-Contraction Coupling in Experimental Cardiac Hypertrophy and Heart Failure

1997 • 754 citations

Theory of excitation-contraction coupling in cardiac muscle

1992 • 651 citations

Purification of the ryanodine receptor and identity with feet structures of junctional terminal cisternae of sarcoplasmic reticulum from fast skeletal muscle.

1987 • 607 citations

Fractional SR Ca release is regulated by trigger Ca and SR Ca content in cardiac myocytes

1995 • 545 citations

Alterations of Sarcoplasmic Reticulum Proteins in Failing Human Dilated Cardiomyopathy

1995 • 530 citations

Calcium sparks and [Ca2+]i waves in cardiac myocytes

1996 • 524 citations

Altered sarcoplasmic reticulum Ca2(+)-ATPase gene expression in the human ventricle during end-stage heart failure.

1990 • 486 citations

Alterations in sarcoplasmic reticulum gene expression in human heart failure. A possible mechanism for alterations in systolic and diastolic properties of the failing myocardium.

1993 • 473 citations

Alterations in Intracellular Calcium Handling Associated With the Inverse Force-Frequency Relation in Human Dilated Cardiomyopathy

1995 • 385 citations

Unchanged Protein Levels of SERCA II and Phospholamban but Reduced Ca ²⁺ Uptake and Ca ²⁺ -ATPase Activity of Cardiac Sarcoplasmic Reticulum From Dilated Cardiomyopathy Patients Compared With Patients With Nonfailing Hearts

1995 • 384 citations

Selective changes in cardiac gene expression during compensated hypertrophy and the transition to cardiac decompensation in rats with chronic aortic banding.

1993 • 359 citations

Rapid Adaptation of Cardiac Ryanodine Receptors: Modulation by Mg ²⁺ and Phosphorylation

1995 • 349 citations

Phospholamban: A Prominent Regulator of Myocardial Contractility

1996 • 346 citations

Alterations in cardiac gene expression during the transition from stable hypertrophy to heart failure. Marked upregulation of genes encoding extracellular matrix components.

1994 • 344 citations

Function of the sarcoplasmic reticulum and expression of its Ca2(+)-ATPase gene in pressure overload-induced cardiac hypertrophy in the rat.

1990 • 339 citations

Ryanodine Receptor Adaptation: Control Mechanism of Ca ²⁺ -Induced Ca ²⁺ Release in Heart

1993 • 328 citations

Differential regulation of two types of intracellular calcium release channels during end-stage heart failure.

1995 • 243 citations

Relation Between the Sarcolemmal Ca ²⁺ Current and Ca ²⁺ Sparks and Local Control Theories for Cardiac Excitation-Contraction Coupling

1996 • 231 citations

Ca(2+)-transporting ATPase, phospholamban, and calsequestrin levels in nonfailing and failing human myocardium.

1994 • 228 citations

Expression of dihydropyridine receptor (Ca2+ channel) and calsequestrin genes in the myocardium of patients with end-stage heart failure.

1992 • 216 citations

Calcium uptake by cardiac sarcoplasmic reticulum in human dilated cardiomyopathy

1987 • 207 citations

Reduced Contraction and Altered Frequency Response of Isolated Ventricular Myocytes From Patients With Heart Failure

1995 • 205 citations

Selective gene expression in failing human heart. Quantification of steady-state levels of messenger RNA in endomyocardial biopsies using the polymerase chain reaction.

1991 • 199 citations

Voltage-Independent Calcium Release in Heart Muscle

1990 • 183 citations

Differences in cardiac calcium release channel (ryanodine receptor) expression in myocardium from patients with end-stage heart failure caused by ischemic versus dilated cardiomyopathy.

1992 • 182 citations

Messenger RNA expression and immunological quantification of phospholamban and SR-Ca2+-ATPase in failing and nonfailing human hearts

2000 • 174 citations

Local, stochastic release of Ca2+ in voltage‐clamped rat heart cells: visualization with confocal microscopy.

1994 • 168 citations

Molecular cloning and characterization of a Ca2+ + Mg2+-dependent adenosine triphosphatase from rat cardiac sarcoplasmic reticulum. Regulation of its expression by pressure overload and developmental stage.

1989 • 158 citations

Sarcoplasmic reticulum calsequestrins: Structural and functional properties

1994 • 155 citations

Ca2+ uptake by cardiac sarcoplasmic reticulum from patients with idiopathic dilated cardiomyopathy.

1989 • 148 citations

cAMP concentrations, cAMP dependent protein kinase activity, and phospholamban in non-failing and failing myocardium

1994 • 134 citations

Changes in intracellular calcium during mechanical alternans in isolated ferret ventricular muscle.

1990 • 127 citations

Sarcoplasmic reticulum Ca2+ATPase and phospholamban mRNA and protein levels in end-stage heart failure due to ischemic or dilated cardiomyopathy

1996 • 115 citations

Downregulation of sarcoplasmic reticulum Ca(2+)-ATPase during progression of left ventricular hypertrophy

1997 • 101 citations

Decreased expression of cardiac sarcoplasmic reticulum Ca2+-pump ATPase in congestive heart failure due to myocardial infarction

1996 • 100 citations

Measurement of Free Ca2+ in Sarcoplasmic Reticulum in Perfused Rabbit Heart Loaded with 1,2-Bis(2-amino-5,6-difluorophenoxy)ethane-N,N,N′,N′-tetraacetic Acid by 19F NMR

1996 • 96 citations

Structure of sarcoplasmic reticulum.

1980 • 94 citations

Calcium cycling proteins and forcefrequency relationship in heart failure

1996 • 93 citations

Excitation‐contraction coupling in the heart: the state of the question ¹

1992 • 85 citations

Phospholamban-mediated stimulation of Ca2+ uptake in sarcoplasmic reticulum from normal and failing hearts.

1990 • 80 citations

Decreased expression of cardiac sarcoplasmic reticulum Ca2+-pump ATPase in congestive heart failure due to myocardial infarction

1996 • 78 citations

Abnormal Cai2+ handling is the primary cause of mechanical alternans: study in ferret ventricular muscles

1991 • 77 citations

A comparison of alternation in myocardial action potentials and contractility

1971 • 75 citations

Phospholamban: a regulatory protein of the cardiac sarcoplasmic reticulum.

1975 • 72 citations

Protein kinase inhibitors reduce SR Ca transport in permeabilized cardiac myocytes

1994 • 63 citations

Post-extrasystolic potentiation and the force-frequency relationship: Differential augmentation of myocardial contractility in working myocardium from patients with end-stage heart failure

1990 • 63 citations

Localization of Ca2+ + Mg2+-ATPase of the sarcoplasmic reticulum in adult rat papillary muscle.

1982 • 60 citations

Calcium transport proteins in the nonfailing and failing heart: gene expression and function

1995 • 60 citations

The density of ryanodine receptors decreases with pressure overload‐induced rat cardiac hypertrophy

1991 • 56 citations

Calcium accumulation and release by the sarcoplasmic reticulum of digitonin-lysed adult mammalian ventricular cardiomyocytes.

1990 • 52 citations

Local activation of contraction in isolated rat ventricular myocytes

1990 • 51 citations

Mechanical alternans and the force-frequency relationship in failing rat hearts

1995 • 47 citations

Calcium is released from the junctional sarcoplasmic reticulum during cardiac muscle contraction

1991 • 38 citations

Unaltered ryanodine receptor protein levels in ischemic cardiomvopathy

1996 • 37 citations

Pulsus alternans

1993 • 30 citations

Abnormal intracellular calcium handling in myocardium from patients with end-stage heart failure.

1987 • 29 citations

Postextrasystolic Mechanical Restitution in Closed-Chest Dogs

1995 • 18 citations

Altered inotropism in the failing human myocardium

1996 • 11 citations

Mechanical restitution during alternans in guinea pig papillary muscles

1992 • 11 citations