Antigen-induced mucosal T cell activation is followed by Th1 T cell suppression in continuously fed ovalbumin TCR-transgenic mice

A CD4+T-cell subset inhibits antigen-specific T-cell responses and prevents colitis

1997 • 3,625 citations

Regulatory T Cell Clones Induced by Oral Tolerance: Suppression of Autoimmune Encephalomyelitis

1994 • 1,995 citations

Oral Tolerance: Immunologic Mechanisms and Treatment of Animal and Human Organ-Specific Autoimmune Diseases by Oral Administration of Autoantigens

1994 • 895 citations

Peripheral deletion of antigen-reactive T cells in oral tolerance

1995 • 775 citations

Oral tolerance in experimental autoimmune encephalomyelitis. III. Evidence for clonal anergy.

1991 • 450 citations

Experimental granulomatous colitis in mice is abrogated by induction of TGF-beta-mediated oral tolerance.

1996 • 444 citations

Antigen-driven bystander suppression after oral administration of antigens.

1991 • 438 citations

Suppression of experimental autoimmune encephalomyelitis by oral administration of myelin basic protein and its fragments.

1988 • 404 citations

Reciprocal IFN-γ and TGF-β responses regulate the occurrence of mucosal inflammation

1997 • 399 citations

Suppression of type II collagen-induced arthritis by intragastric administration of soluble type II collagen.

1986 • 357 citations

Induction of Autoimmune Diabetes by Oral Administration of Autoantigen

1996 • 261 citations

Analysis of Th1 and Th2 cells in murine gut-associated tissues. Frequencies of CD4+ and CD8+ T cells that secrete IFN-gamma and IL-5.

1990 • 226 citations

Anergy and exhaustion are independent mechanisms of peripheral T cell tolerance.

1995 • 225 citations

High dose oral tolerance in ovalbumin TCR-transgenic mice: systemic neutralization of IL-12 augments TGF-beta secretion and T cell apoptosis.

1996 • 221 citations

Antiinflammatory Effects of CD95 Ligand (FasL)-induced Apoptosis

1998 • 220 citations

Induction of Rapid T Cell Activation and Tolerance by Systemic Presentation of an Orally Administered Antigen

1998 • 219 citations

Factors involved in the differentiation of TGF-beta-producing cells from naive CD4+ T cells: IL-4 and IFN-gamma have opposing effects, while TGF-beta positively regulates its own production.

1998 • 205 citations

Oral tolerance in experimental autoimmune uveoretinitis. Distinct mechanisms of resistance are induced by low dose vs high dose feeding protocols.

1993 • 184 citations

T helper 2 cells are subject to high dose oral tolerance and are not essential for its induction.

1995 • 171 citations

Oral Tolerance to Myelin Basic Protein Induces Regulatory TGF-β-Secreting T Cells in Peyer's Patches of SJL Mice

1994 • 151 citations

Factors Involved in the Differentiation of TGF-β-Producing Cells from Naive CD4+ T Cells: IL-4 and IFN-γ Have Opposing Effects, While TGF-β Positively Regulates Its Own Production

1998 • 145 citations

The in vitro production of cytokines by mucosal lymphocytes immunized by oral administration of keyhole limpet hemocyanin using cholera toxin as an adjuvant

1991 • 120 citations

Selective induction of Th2 cells in murine Peyer's patches by oral immunization

1992 • 118 citations

Oral tolerance.

1998 • 102 citations

Inductive Events in Oral Tolerance in the TCR Transgenic Adoptive Transfer Model

1997 • 98 citations

Antigen-Specific T Cell Activation and Proliferation During Oral Tolerance Induction

1999 • 97 citations

Lack of orally induced systemic unresponsiveness in IFN-gamma knockout mice.

1998 • 81 citations

Peripheral tolerance of T_h2 lymphocytes induced by continuous feeding of ovalbumin

1996 • 80 citations

Regulation of transforming growth factor‐β production by interleukin‐12

1997 • 77 citations

Interferon‐γ receptor‐deficient mice exhibit impaired gut mucosal immune responses but intact oral tolerance

1997 • 72 citations

Lack of Orally Induced Systemic Unresponsiveness in IFN-γ Knockout Mice

1998 • 61 citations

CD4+ T cells with specific reactivity against astrovirus isolated from normal human small intestine

1998 • 56 citations

The Oral Administration of Low-Dose Antigen Induces Activation Followed by Tolerization, While High-Dose Antigen Induces Tolerance without Activation

1997 • 51 citations

Stimulation of antigen-specific T- and B-cell memory in local as well as systemic lymphoid tissues following oral immunization with cholera toxin adjuvant.

1993 • 50 citations

Orally Induced Peripheral Nonresponsiveness Is Maintained in the Absence of Functional Th1 or Th2 Cells

1999 • 49 citations

Anti‐IL‐10 Treatment Does Not Block Either the Induction or the Maintenance of Orally Induced Tolerance to Ova

1995 • 44 citations

Normal induction of oral tolerance in the absence of a functional IL-12-dependent IFN-gamma signaling pathway.

1999 • 38 citations

Normal Induction of Oral Tolerance in the Absence of a Functional IL-12-Dependent IFN-γ Signaling Pathway

1999 • 30 citations

Selective suppression of antigen-specific Th2 cells by continuous micro-dose oral tolerance

1998 • 25 citations