Cap binding complexes and cellular growth control

Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function

1994 • 1,222 citations

TRANSLATIONAL CONTROL IN MAMMALIAN CELLS

1991 • 1,041 citations

PHAS-I as a Link Between Mitogen-Activated Protein Kinase and Translation Initiation

1994 • 672 citations

Mechanism and regulation of eukaryotic protein synthesis

1992 • 591 citations

Inhibition of HeLa cell protein synthesis following poliovirus infection correlates with the proteolysis of a 220,000-dalton polypeptide associated with eucaryotic initiation factor 3 and a cap binding protein complex.

1982 • 580 citations

Recognition of cap structure in splicing in vitro of mRNA precursors

1984 • 575 citations

Internal initiation of translation mediated by the 5′ leader of a cellular mRNA

1991 • 554 citations

Regulated phosphorylation and low abundance of HeLa cell initiation factor eIF-4F suggest a role in translational control. Heat shock effects on eIF-4F.

1987 • 494 citations

New initiation factor activity required for globin mRNA translation.

1983 • 416 citations

Monomethylated cap structures facilitate RNA export from the nucleus

1990 • 411 citations

ATP-dependent unwinding of messenger RNA structure by eukaryotic initiation factors.

1985 • 404 citations

Dominant negative mutants of mammalian translation initiation factor eIF-4A define a critical role for eIF-4F in cap-dependent and cap-independent initiation of translation.

1994 • 384 citations

Regulation of eukaryotic protein synthesis by initiation factors.

1993 • 300 citations

Mapping the cleavage site in protein synthesis initiation factor eIF-4 gamma of the 2A proteases from human Coxsackievirus and rhinovirus.

1993 • 268 citations

The Regulation of Initiation of Mammalian Protein Synthesis

1981 • 266 citations

Eukaryotic mRNA cap binding protein: purification by affinity chromatography on sepharose-coupled m7GDP.

1979 • 259 citations

Cap recognition and the entry of mRNA into the protein synthesis initiation cycle

1988 • 256 citations

Increased expression of eukaryotic translation initiation factors eIF-4E and eIF-2 alpha in response to growth induction by c-myc.

1993 • 246 citations

mRNA cap binding proteins: essential factors for initiating translation

1985 • 242 citations

Involvement of eukaryotic initiation factor 4A in the cap recognition process.

1983 • 236 citations

The mouse protein synthesis initiation factor 4A gene family includes two related functional genes which are differentially expressed.

1988 • 229 citations

Involvement of the 24-kDa cap-binding protein in regulation of protein synthesis in mitosis.

1987 • 220 citations

Homeotic gene Antennapedia mRNA contains 5'-noncoding sequences that confer translational initiation by internal ribosome binding.

1992 • 215 citations

Translational Regulation of Gene Expression 2

1993 • 202 citations

Immunological detection of the messenger RNA cap-binding protein.

1985 • 201 citations

Differential stimulation of phosphorylation of initiation factors eIF-4F, eIF-4B, eIF-3, and ribosomal protein S6 by insulin and phorbol esters.

1990 • 197 citations

TIF4631 and TIF4632: two yeast genes encoding the high-molecular-weight subunits of the cap-binding protein complex (eukaryotic initiation factor 4F) contain an RNA recognition motif-like sequence and carry out an essential function.

1993 • 186 citations

Purification of a factor that restores translation of vesicular stomatitis virus mRNA in extracts from poliovirus-infected HeLa cells.

1980 • 164 citations

Cap-dependent RNA splicing in a HeLa nuclear extract.

1985 • 156 citations

Regulation of initiation factors during translational repression caused by serum depletion. Covalent modification.

1985 • 153 citations

Poly(A) site cleavage in a HeLa nuclear extract is dependent on downstream sequences

1985 • 152 citations

ATP/Mg⁺⁺-dependent cross-linking of cap binding proteins to the 5′ end of eukaryotic mRNA

1981 • 150 citations

A cap binding protein that may mediate nuclear export of RNA polymerase II-transcribed RNAs.

1992 • 150 citations

Influence of 5' proximal secondary structure on the translational efficiency of eukaryotic mRNAs and on their interaction with initiation factors.

1986 • 149 citations

An essential yeast protein, encoded by duplicated genes TIF1 and TIF2 and homologous to the mammalian translation initiation factor eIF-4A, can suppress a mitochondrial missense mutation.

1989 • 142 citations

Cap recap: The involvement of eIF-4F in regulating gene expression

1992 • 134 citations

Alteration of the major phosphorylation site of eukaryotic protein synthesis initiation factor 4E prevents its association with the 48 S initiation complex.

1990 • 133 citations

Translation factors as effectors of cell growth and tumorigenesis

1993 • 128 citations

Export of mRNA from microinjected nuclei of Xenopus laevis oocytes.

1992 • 121 citations

Phorbol esters stimulate phosphorylation of eukaryotic initiation factors 3, 4B, and 4F

1989 • 121 citations

Preferential excision of the 5' proximal intron from mRNA precursors with two introns as mediated by the cap structure.

1987 • 114 citations

Proteolysis of the p220 component of the cap-binding protein complex is not sufficient for complete inhibition of host cell protein synthesis after poliovirus infection

1987 • 114 citations

RNA unwinding in translation: assembly of helicase complex intermediates comprising eukaryotic initiation factors eIF-4F and eIF-4B.

1991 • 109 citations

Photochemical Cross-Linking of Cap Binding Proteins to Eucaryotic mRNAs: Effect of mRNA 5′ Secondary Structure

1985 • 102 citations

Reovirus mRNA can be covalently crosslinked via the 5' cap to proteins in initiation complexes.

1977 • 102 citations

Transport of RNA between nucleus and cytoplasm

1992 • 93 citations

High-level synthesis in Escherichia coli of functional cap-binding eukaryotic initiation factor eIF-4E and affinity purification using a simplified cap-analog resin

1988 • 92 citations

Eukaryotic initiation factor (eIF)-4F. Implications for a role in internal initiation of translation

1991 • 91 citations

Novel phosphorylation sites of eukaryotic initiation factor-4F and evidence that phosphorylation stabilizes interactions of the p25 and p220 subunits.

1993 • 90 citations

Purification of the messenger RNA cap-binding protein using a new affinity medium

1984 • 89 citations

Heat shock impairs the interaction of cap-binding protein complex with 5' mRNA cap.

1991 • 87 citations

Isolation and sequence of the cDNAs encoding the subunits of the isozyme form of wheat protein synthesis initiation factor 4F

1992 • 87 citations

Protein synthesis, cell growth and oncogenesis

1991 • 82 citations

A spectroscopic study of the binding of m7GTP and m7GpppG to human protein synthesis initiation factor 4E

1989 • 82 citations

Isolation and characterization of factors from wheat germ that exhibit eukaryotic initiation factor 4B activity and overcome 7-methylguanosine 5'-triphosphate inhibition of polypeptide synthesis.

1985 • 82 citations

Processing and nucleo-cytoplasmic transport of histone gene transcripts

1984 • 79 citations

A nuclear cap binding protein from HeLa cells

1990 • 78 citations

Increased phosphorylation of eukaryotic initiation factor 4α during early activation of T lymphocytes correlates with increased initiation factor 4F complex formation

1993 • 71 citations

Lack of direct correlation between p220 cleavage and the shut-off of host translation after poliovirus infection

1992 • 70 citations

Multiple cis-acting signals for export of pre-U1 snRNA from the nucleus.

1993 • 67 citations

In Vitro Synthesis, Phosphorylation, and Localization on 48 S Initiation Complexes of Human Protein Synthesis Initiation Factor 4E

1989 • 67 citations

Eukaryotic initiation factors-4E and -4F stimulate 5' cap-dependent as well as internal initiation of protein synthesis.

1992 • 66 citations

The cap-binding protein complex in uninfected and poliovirus-infected HeLa cells.

1987 • 66 citations

Site-directed mutagenesis of the tryptophan residues in yeast eukaryotic initiation factor 4E. Effects on cap binding activity.

1988 • 66 citations

Identification and characterization of cap-binding proteins from yeast

1989 • 62 citations

Photochemical cross-linking of cap binding proteins to eucaryotic mRNAs: effect of mRNA 5' secondary structure.

1985 • 55 citations

CAP binding proteins associated with the nucleus

1983 • 54 citations

Remarks on the mechanism of ribosome binding to eukaryotic mRNAs.

1993 • 52 citations

Assembly of pre-mRNA splicing complex is cap dependent

1987 • 52 citations

Measures and countermeasures in the modulation of initiation factor activities by viruses.

1990 • 51 citations

A polypeptide which reverses cap analogue inhibition of cell-free protein synthesis. Purification and binding to capped oligonucleotides.

1982 • 46 citations

Identification of nuclear cap specific proteins in HeLa cells

1987 • 45 citations

A wheat germ cap-site factor functional in protein chain initiation

1986 • 30 citations

Translational recognition of messenger ribonucleic acid caps as a function of pH

1983 • 28 citations

Combination of Trp and Glu residues for recognition of mRNA cap structure Analysis of m⁷G base recognition site of human cap binding protein (IF‐4E) by site‐directed mutagenesis

1991 • 23 citations

eIF-4E Phosphorylation and the Regulation of Protein Synthesis

1993 • 14 citations

Design and preparation of affinity columns for the purification of eukaryotic messenger ribonucleic acid cap binding protein

1981 • 11 citations

Introduction to translational initiation factors and their regulation by phosphorylation

1993 • 10 citations

Deleted Work

1955 • 0 citations