Endothelial Heme Oxygenase-1 Induction by Hypoxia

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

1987 • 10,774 citations

Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide.

1987 • 5,027 citations

Bilirubin Is an Antioxidant of Possible Physiological Importance

1987 • 3,406 citations

THE HEME OXYGENASE SYSTEM:A Regulator of Second Messenger Gases

1997 • 2,481 citations

Glutathione and its role in cellular functions

1999 • 1,693 citations

S-nitrosohaemoglobin: a dynamic activity of blood involved in vascular control

1996 • 1,604 citations

Microsomal Heme Oxygenase

1969 • 1,348 citations

Heme oxygenase is the major 32-kDa stress protein induced in human skin fibroblasts by UVA radiation, hydrogen peroxide, and sodium arsenite.

1989 • 1,273 citations

Reduced stress defense in heme oxygenase 1-deficient cells

1997 • 1,263 citations

Oxygen sensing and molecular adaptation to hypoxia

1996 • 1,187 citations

Activation of the Cardiac Calcium Release Channel (Ryanodine Receptor) by Poly-S-Nitrosylation

1998 • 983 citations

Hypoxia-inducible Factor-1 Mediates Transcriptional Activation of the Heme Oxygenase-1 Gene in Response to Hypoxia

1997 • 775 citations

Fas-Induced Caspase Denitrosylation

1999 • 742 citations

Smooth muscle cell-derived carbon monoxide is a regulator of vascular cGMP.

1995 • 709 citations

A hypoxia-responsive element mediates a novel pathway of activation of the inducible nitric oxide synthase promoter.

1995 • 630 citations

Mechanism of Nitric Oxide Release from S-Nitrosothiols

1996 • 580 citations

Gene expression and the thiol redox state

1999 • 511 citations

Plasma glutathione and glutathione disulfide in the rat: regulation and response to oxidative stress.

1983 • 463 citations

[25] Nitric-oxide synthase assays

1994 • 429 citations

Endothelial cell expression of vasoconstrictors and growth factors is regulated by smooth muscle cell-derived carbon monoxide.

1995 • 355 citations

Nitrosative Stress: Activation of the Transcription Factor OxyR

1996 • 351 citations

Nitric Oxide Induces Heme Oxygenase-1 Gene Expression and Carbon Monoxide Production in Vascular Smooth Muscle Cells

1997 • 327 citations

Nitric oxide reacts with intracellular glutathione and activates the hexose monophosphate shunt in human neutrophils: evidence for S-nitrosoglutathione as a bioactive intermediary.

1994 • 316 citations

Thiol Compounds Interact with Nitric Oxide in Regulating Heme Oxygenase-1 Induction in Endothelial Cells

1997 • 297 citations

Heme Oxygenase-1–Derived Carbon Monoxide Contributes to the Suppression of Acute Hypertensive Responses In Vivo

1998 • 275 citations

The heme oxygenase pathway and its interaction with nitric oxide in the control of cellular homeostasis

1999 • 270 citations

The Biological Significance and Physiological Role of Heme Oxygenase

1996 • 254 citations

The physiological significance of heme oxygenase

1988 • 240 citations

Carbon monoxide is a major contributor to the regulation of vascular tone in aortas expressing high levels of haeme oxygenase‐1

1998 • 239 citations

Loss and Degradation of Enzyme-bound Heme Induced by Cellular Nitric Oxide Synthesis

1995 • 237 citations

Endogenous glutathione levels modulate both constitutive and UVA radiation/hydrogen peroxide inducible expression of the human heme oxygenase gene

1992 • 212 citations

Effects of acidosis on phosphorylation of phospholamban and troponin I in rat cardiac muscle

1996 • 209 citations

Regulation of bovine endothelial constitutive nitric oxide synthase by oxygen.

1995 • 204 citations

Peroxynitrite induces haem oxygenase-1 in vascular endothelial cells: a link to apoptosis

1999 • 194 citations

Selection and Analysis of a Mutant Cell Line Defective in the Hypoxia-inducible Factor-1 α-Subunit (HIF-1α)

1998 • 193 citations

Detection of nitric oxide production from a perfused organ by a luminol-hydrogen peroxide system

1993 • 190 citations

Glutathione Depletion Induces Heme Oxygenase‐1 (HSP32) mRNA and Protein in Rat Brain

1993 • 180 citations

Nitric Oxide-Dependent Induction of Glutathione Synthesis through Increased Expression of γ-Glutamylcysteine Synthetase

1998 • 125 citations

Hypoxia decreases constitutive nitric oxide synthase transcript and protein in cultured endothelial cells

1996 • 112 citations

Interaction of heme oxygenase‐2 with nitric oxide donors

1999 • 109 citations

Mechanisms of endotoxin-induced haem oxygenase mRNA accumulation in mouse liver: synergism by glutathione depletion and protection by N-acetylcysteine

1994 • 104 citations

Stress Proteins and SH-Groups in Oxidant-Induced Cellular Injury After Chronic Ethanol Administration in Rat

1998 • 96 citations

Hypoxia decreases constitutive nitric oxide synthase transcript and protein in cultured endothelial cells

1996 • 90 citations

Nitric oxide is involved in heat‐induced HSP70 accumulation

1995 • 86 citations

Heme oxygenase-1 induction in skeletal muscle cells: hemin and sodium nitroprusside are regulators in vitro

1998 • 79 citations

Nitric oxide mediates the lipopolysaccharide dependent upregulation of the heme oxygenase-1 gene expression in cultured rat Kupffer cells

1999 • 72 citations

Involvement of the Heme Oxygenase–Carbon Monoxide Pathway in Keratinocyte Proliferation

1997 • 67 citations

A Precursor of the Nitric Oxide Donor SIN-1 Modulates the Stress Protein Heme Oxygenase-1 in Rat Liver

1996 • 55 citations

Differential effects of nitric oxide–mediated S-nitrosylation on p50 and c-jun DNA binding

1998 • 55 citations

Fibre type specificity of haem oxygenase‐1 induction in rat skeletal muscle

1999 • 27 citations

Induction of hepatic heme oxygenase and changes in cytochrome P-450s in response to oxidative stress produced by stilbenes and stilbene oxides in rats.

1997 • 20 citations