Translocation t(6;9) in acute non-lymphocytic leukaemia results in the formation of a DEK-CAN fusion gene

The Leucine Zipper: A Hypothetical Structure Common to a New Class of DNA Binding Proteins

1988 • 3,479 citations

Somatic generation of antibody diversity

1983 • 3,275 citations

Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RARα with a novel putative transcription factor, PML

1991 • 1,463 citations

The PML-RARα fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR

1991 • 1,371 citations

Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2

1990 • 910 citations

Progression from lymphoid hyperplasia to high-grade malignant lymphoma in mice transgenic for the t(14;18)

1991 • 876 citations

Identification of cooperating oncogenes in Eμ-myc transgenic mice by provirus tagging

1991 • 765 citations

A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in pre-B all

1990 • 726 citations

Acute leukaemia in bcr/abl transgenic mice

1990 • 701 citations

Chromosomal translocation t(1;19) results in synthesis of a homeobox fusion mRNA that codes for a potential chimeric transcription factor

1990 • 692 citations

A protein binds to a satellite DNA repeat at three specific sites that would be brought into mutual proximity by DNA folding in the nucleosome

1984 • 674 citations

Extensive homology among the largest subunits of eukaryotic and prokaryotic RNA polymerases

1985 • 670 citations

Characterization and colocalization of steroid binding and dimerization activities in the mouse estrogen receptor

1990 • 617 citations

A structural taxonomy of DNA-binding domains

1991 • 615 citations

Chromosome Aberrations and Cancer

1991 • 598 citations

Novel zinc finger gene implicated as myc collaborator by retrovirally accelerated lymphomagenesis in Eμ-myc transgenic mice

1991 • 516 citations

Predisposition to lymphomagenesis in pim-1 transgenic mice: Cooperation with c-myc and N-myc in murine leukemia virus-induced tumors

1989 • 497 citations

Can, a putative oncogene associated with myeloid leukemogenesis, may be activated by fusion of its 3' half to different genes: characterization of the set gene.

1992 • 392 citations

Dimers, leucine zippers and DNA-binding domains

1990 • 377 citations

The translocation (6;9), associated with a specific subtype of acute myeloid leukemia, results in the fusion of two genes, dek and can, and the expression of a chimeric, leukemia-specific dek-can mRNA.

1992 • 377 citations

D11S287, a putative oncogene on chromosome 11q13, is amplified and expressed in squamous cell and mammary carcinomas and linked to BCL-1.

1991 • 376 citations

Characterization of a candidate bcl-1 gene.

1991 • 357 citations

Leukemia and the disruption of normal hematopoiesis

1991 • 357 citations

Chromosomal banding patterns in acute nonlymphocytic leukemia

1976 • 351 citations

A unique structure at the carboxyl terminus of the largest subunit of eukaryotic RNA polymerase II.

1985 • 346 citations

Commitment and activation at pol II promoters: A tail of protein-protein interactions

1990 • 332 citations

Transcription factor AP-4 contains multiple dimerization domains that regulate dimer specificity.

1990 • 330 citations

SPXX, a frequent sequence motif in gene regulatory proteins

1989 • 276 citations

Activation of thec-mycOncogene in a Precursor-B-Cell Blast Crisis of Follicular Lymphoma, Presenting as Composite Lymphoma

1988 • 258 citations

Transcription factors: a new family gathers at the cAMP response site

1990 • 244 citations

LINE-1: A mammalian transposable element

1987 • 224 citations

High-Resolution Chromosomes as an Independent Prognostic Indicator in Adult Acute Nonlymphocytic Leukemia

1984 • 224 citations

Increased Frequency of N-Region Insertion in a Murine Pre-B-Cell Line Infected with a Terminal Deoxynucleotidyl Transferase Retroviral Expression Vector

1987 • 214 citations

Oncogenic conversion of transcription factors by chromosomal translocations

1991 • 209 citations

Recurrent chromosomal defects are found in most patients with non-Hodgkin's-lymphoma

1984 • 191 citations

Clinical and laboratory features of de novo acute myeloid leukaemia with trilineage myelodysplasia

1987 • 185 citations

Anionic regions in nuclear proteins.

1987 • 167 citations

Making sense out of LINES: long interspersed repeat sequences in mammalian genomes

1985 • 162 citations

Increased frequency of N-region insertion in a murine pre-B-cell line infected with a terminal deoxynucleotidyl transferase retroviral expression vector.

1987 • 125 citations

Evolution of B-cell malignancy: pre-B-cell leukemia resulting from MYC activation in a B-cell neoplasm with a rearranged BCL2 gene.

1988 • 121 citations

Characterization of the translocation breakpoint sequences of two DEK‐CAN fusion genes present in t(6;9) acute myeloid leukemia and a SET‐CAN fusion gene found in a case of acute undifferentiated leukemia

1992 • 115 citations

Evolution of karyotypes in acute nonlymphocytic leukemia.

1979 • 115 citations

Increased numbers of marrow basophils may be associated with a t(6;9) in ANLL

1985 • 111 citations

The human T cell receptor genes are targets for chromosomal abnormalities in T cell tumors

1989 • 109 citations

The translocation (6;9) (p23;q34) shows consistent rearrangement of two genes and defines a myeloproliferative disorder with specific clinical features

1992 • 109 citations

The (6;9) chromosome translocation, associated with a specific subtype of acute nonlymphocytic leukemia, leads to aberrant transcription of a target gene on 9q34.

1990 • 107 citations

The heptad repeat in the largest subunit of RNA polymerase II binds by intercalating into DNA

1990 • 103 citations

Chromosome pattern in childhood acute nonlymphocytic leukemia (ANLL)

1982 • 101 citations

Marrow cytogenetic and cell-culture analyses of the myelodysplastic syndromes: insights to pathophysiology and prognosis.

1983 • 90 citations

Fusion of the nuclear oncoproteins v-Myb and v-Ets is required for the leukemogenicity of E26 virus

1991 • 86 citations

Chromosome pattern in childhood acute nonlymphocytic leukemia (ANLL)

1982 • 83 citations

Nonrandom cytogenetic changes in New Zealand patients with acute myeloid leukemia

1983 • 68 citations

Myc meets its max

1991 • 66 citations

Ph1+bcr- acute leukemias: implication of Alu sequences in a chromosomal translocation occurring in the new cluster region within the BCR gene.

1989 • 66 citations

Reciprocal translocation t(6;9)(p21;q33): A new characteristic chromosome anomaly in myeloid leukemias

1983 • 50 citations

Acute myeloblastic leukemia (AML) with t(6;9) (p23;q34): A specific subgroup of AML?

1983 • 44 citations

Translocation t(6;9) occurring in acute myelofibrosis, myelodysplastic syndrome, and acute nonlymphocytic leukemia suggests multipotent stem cell involvement

1989 • 42 citations

High resolution banding analysis of the reciprocal translocation t(6;9) in acute nonlymphocytic leukemia

1986 • 39 citations

Dek-can rearrangement in translocation (6;9)(p23;q34).

1992 • 37 citations

Translocation (6;9)(p23;q34) in acute nonlymphocytic leukemia

1983 • 37 citations

Chromosome abnormalities in chronic myeloid leukemia in children

1983 • 34 citations

Terminal deoxynucleotidyl transferase positive subpopulations occur in the majority of ANLL: implications for the detection of minimal disease.

1990 • 34 citations

Chromosomal localization and characterization of c-abl in the t(6;9) of acute nonlymphocytic leukemia.

1985 • 32 citations

Chromosomal rearrangements with a common breakpoint at 6p23 in five cases of myeloid leukemia

1983 • 31 citations

Translocation (6;9)(p23;q34) in smoldering leukemia and acute nonlymphocytic leukemia

1987 • 27 citations

Translocation (6;9) may be associated with a specific TdT-positive immunological phenotype in ANLL.

1988 • 27 citations

Translocation (6;9)(p23;q34) in acute nonlymphocytic leukemia: Three new cases

1985 • 26 citations

The human pim-1 gene is not directly activated by the translocation (6;9) in acute nonlymphocytic leukemia.

1989 • 25 citations

Complex chromosomal abnormalities in acute nonlymphocytic leukemia

1986 • 23 citations

Acute myelomonocytic leukemia (AML‐M4) and translocation t(6;9) (p23;q34): Two additional patients with prominent myelodysplasia

1987 • 23 citations

Expression of the ETS2 and transferrin receptor genes in Philadelphia‐positive chronic myeloid leukemia patients with a reciprocal t(3;21)

1992 • 21 citations

Translocation t(6;9)(p22.3;q34) in myelodysplastic syndrome—Refractory anemia with excess blasts

1987 • 19 citations

t(6;9) in bone marrow cells in two patients with sarcoidosis and acute myeloid leukemia

1989 • 14 citations

Loss of the Y chromosome associated with translocation t(6;9)(p23;q34) in a patient with acute nonlymphocytic leukemia

1989 • 13 citations