The immune system, depression and the action of antidepressants

The Stress of Life

1956 • 5,480 citations

Biological basis of the behavior of sick animals

1988 • 2,123 citations

Immune-Neuro-Endocrine Interactions: Facts and Hypotheses

1996 • 1,477 citations

The Pathophysiologic Roles of Interleukin-6 in Human Disease

1998 • 1,132 citations

Cytokines for psychologists: Implications of bidirectional immune-to-brain communication for understanding behavior, mood, and cognition.

1998 • 1,130 citations

Cytokines and the nervous system II: actions and mechanisms of action

1995 • 928 citations

The macrophage theory of depression

1991 • 871 citations

Antidepressants and Hypothalamic-Pituitary-Adrenocortical Regulation

1996 • 829 citations

Endotoxin produces a depressive-like episode in rats

1996 • 572 citations

Fatty acid composition in major depression: decreased ω3 fractions in cholesteryl esters and increased C20:4ω6C20:5ω3 ratio in cholesteryl esters and phospholipids

1996 • 426 citations

Tricyclic antidepressants inhibit IL-6, IL-1β and TNF-α release in human blood monocytes and IL-2 and interferon-γ in T cells

1996 • 311 citations

Interleukin‐6 Serum Levels in Depressed Patients before and after Treatment with Fluoxetine

1995 • 301 citations

Distinct roles for CD4 and CD8 as co-receptors in antigen receptor signalling

1993 • 274 citations

Regulation of the HPA Axis by Cytokines

1995 • 270 citations

Molecular Basis of Sickness Behavior^a

1998 • 241 citations

The inflammatory response system and the availability of plasma tryptophan in patients with primary sleep disorders and major depression

1998 • 236 citations

Interleukin 1 receptors in the brain and endocrine tissues

1993 • 228 citations

Synergistic Effects of Interleukin-1β, Interleukin-6, and Tumor Necrosis Factor-α Central Monoamine, Corticosterone, and Behavioral Variations

2000 • 220 citations

Depression, immunocompetence, and prostaglandins of the E series

1986 • 207 citations

Changes in immunoglobulin, complement and acute phase protein levels in the depressed patients and normal controls

1994 • 190 citations

Central injection of IL-10 antagonizes the behavioural effects of lipopolysaccharide in rats

1999 • 177 citations

In the Rat, Interleukin- lα and -β Stimulate Adrenocorticotropin and Catecholamine Release*

1989 • 174 citations

Regulation of the Human Serotonin Transporter by Interleukin-1β

1995 • 156 citations

Elevated levels of prostaglandin e2 and thromboxane B2 in depression

1983 • 139 citations

Effects of Antidepressants on Weight and on the Plasma Levels of Leptin, TNF-α and Soluble TNF Receptors A Longitudinal Study in Patients Treated with Amitriptyline or Paroxetine

2000 • 138 citations

Cytokines

1998 • 135 citations

Differential effect of chronic antidepressant treatments on lipopolysaccharide-induced depressive-like behavioural symptoms in the rat

1999 • 128 citations

The Effect of Estrogen and Progesterone on Uterine Prostaglandin Biosynthesis in the Ovariectomized Rat

1975 • 123 citations

Effects of Serotonin and Serotonergic Agonists and Antagonists on the Production of Interferon-γ and Interleukin-10

2000 • 100 citations

Psychopharmacology of Anxiolytics and Antidepressants

1991 • 94 citations

Olfactory Bulbectomy Provokes a Suppression of Interleukin-1β and Tumour Necrosis Factor-α Production in Response to an in vivo Challenge with Lipopolysaccharide: Effect of Chronic Desipramine Treatment

1999 • 80 citations

Increased biogenic amine release in mouse hypothalamus following immunological challenge: antagonism by indomethacin

1990 • 77 citations

Neutrophil and monocyte phagocytosis in depressed patients

1993 • 72 citations

Are cytokines associated with neuropsychiatric syndromes in humans?

1995 • 61 citations

Induction of interleukin-1β and interleukin-1 receptor antagonist mRNA by chronic treatment with various psychotropics in widespread area of rat brain

1996 • 55 citations

Attentional and mnemonic deficits associated with infectious disease in humans

1999 • 55 citations

Abnormal zymosan-induced neutrophil chemiluminescence as a marker of depression

1990 • 50 citations

Regulation of nitric oxide synthase messenger RNA expression in the rat hippocampus by glucocorticoids

1998 • 50 citations

Stressor-induced alterations in serotonergic activity in an animal model of depression

1999 • 49 citations

The effect of olfactory bulbectomy in the rat, alone or in combination with antidepressants and endogenous factors, on immune function

1995 • 48 citations

Fundamentals of Psychoneuroimmunology

2000 • 41 citations

Actions of the tricyclic antidepressant clomipramine on responses to pressor agents. Interactions with prostaglandin E2

1977 • 40 citations

Brain cytokines and the psychopathology of depression

2001 • 16 citations

Effect of Anti-PGE Antibody On Cell-mediated Immune Response in Thermally Injured Mice

1988 • 14 citations

Type II (glucocorticoid) receptors mediate fast-feedback inhibition of the hypothalamic-pituitary-adrenal axis in man

1996 • 12 citations

Surface contact modulation of inflammatory macrophage antibody dependent cytotoxicity and prostanoid release

1991 • 7 citations