Cellular immunosenescence: An overview

The Effect of Retarded Growth Upon the Length of Life Span and Upon the Ultimate Body Size

1935 • 2,189 citations

Biology of interleukin 1

1988 • 1,547 citations

Immunological studies of aging. Decreased production of and response to T cell growth factor by lymphocytes from aged humans.

1981 • 473 citations

Lymphocyte Phytohemagglutinin Responsiveness, Immunoglobulins and Autoantibodies in Aging Humans

1973 • 286 citations

Beneficial effects of oral zinc supplementation on the immune response of old people

1981 • 270 citations

Reduced β-adrenergic receptor concentrations in ageing man

1977 • 258 citations

Decreased proliferation, interleukin 2 synthesis, and interleukin 2 receptor expression are accompanied by decreased mRNA expression in phytohemagglutinin-stimulated cells from elderly donors.

1988 • 257 citations

Distribution of Human Chromosome Counts in Relation to Age

1961 • 242 citations

Age-Associated Changes in the DNA of Mouse Tissue

1971 • 203 citations

Enumeration of T lymphocyte subsets by monoclonal antibodies in young and aged humans.

1981 • 187 citations

The Free Radical Theory of Aging: Effect of Age on Serum Copper Levels

1965 • 175 citations

Cell-mediated immunity in aged mice: an underlying lesion in IL 2 synthesis.

1982 • 159 citations

Influence of controlled dietary restriction on immunologic function and aging.

1979 • 154 citations

Sensitivity of lymphocytes to prostaglandin E2 increases in subjects over age 70.

1979 • 139 citations

Influence of age on the production and regulation of interleukin-1 in mice.

1985 • 138 citations

Mutation frequency in human lymphocytes increases with age

1984 • 138 citations

Human Lymphocyte Beta-adrenergic Receptors Are Unaltered With Age

1981 • 136 citations

Age-related decrease of ultraviolet light-induced DNA repair synthesis in human peripheral leukocytes.

1979 • 129 citations

Mechanisms of age-related decline in antigen-specific T cell proliferative response: IL-2 receptor expression and recombinant IL-2 induced proliferative response of purified tac-positive T cells

1986 • 114 citations

Measurement of spontaneous and X-irradiation-induced 6-thioguanine-resistant human blood lymphocytes using a T-cell cloning technique

1984 • 102 citations

Effect of dietary 2-mercaptoethanol on the life span, immune system, tumor incidence and lipid peroxidation damage in spleen lymphocytes of aging BC3F1 mice

1984 • 101 citations

Spontaneous development of organ-specific autoimmune lesions in aged C57BL/6 mice.

1989 • 95 citations

The effect of aging on the expression of interleukin 2 messenger ribonucleic acid

1986 • 85 citations

Regulation of immunoglobulin production in pokeweed mitogen-stimulated cultures of lymphocytes from young and old adults.

1982 • 84 citations

Free Radical Theory of Aging: Effect of Free‐Radical‐Reaction Inhibitors on the Immune Response†

1977 • 78 citations

Reduced humoral immune activity in long-lived old mice: an approach to elucidating its mechanisms.

1976 • 69 citations

Interleukin-1 synthesis and activity in aged mice

1984 • 64 citations

Abolished in vitro antibody response in elderly: Exclusive involvement of prostaglandin-induced T suppressor cells

1982 • 63 citations

Subpopulations of mononuclear cells in ageing: expansion of the null cell compartment and decrease in the number of T and B cells in human blood.

1985 • 63 citations

Age-related changes in the immune system of mice of eight medium and long-lived strains and hybrids. I. Organ, cellular, and activity changes

1979 • 62 citations

Delayed Type Hypersensitivity in Zinc Deficient Adult Mice: Impairment and Restoration of Responsivity to Dinitrofluorobenzene

1982 • 60 citations

Age-dependent decline in rejoining of X-ray-induced DNA double-strand breaks in normal human lymphocytes

1989 • 60 citations

Age-related changes of splenic T cells in mice — a flow cytometric analysis

1987 • 59 citations

Increased expression of major histocompatibility complex antigens on lymphocytes from aged mice.

1987 • 54 citations

Effects of aging on cell cooperation and lymphocyte responsiveness to cytokines.

1983 • 51 citations

Cellular and molecular aspects of immune system aging

1981 • 49 citations

In situ hybridization analysis of the age-associated decline in IL-2 mRNA expressing murine T cells

1989 • 43 citations

Reconstitution of T cell functions in aging mice by thymosin α1

1986 • 43 citations

Restoration of impaired immune functions in aging animals. II. Effect of mercaptoethanol in enhancing the reduced primary antibody responsiveness in vitro

1979 • 42 citations

Macrophage-Mediated Depression of T-Cell Proliferation in Zinc-Deficient Mice

1987 • 42 citations

The relationship between aging and ribosomal gene activity in humans as evidenced by silver staining

1981 • 37 citations

Restricted expression of mitogen-induced high affinity IL-2 receptors in aging mice.

1988 • 35 citations

Age-related changes of expression of IL-2 receptor subunits and kinetics of IL-2 internalization in T cells after mitogenic stimulation

1988 • 34 citations

Effects of Age, Sex and Diagnostic X-rays on Chromosome Damage

1984 • 33 citations

Specific antibody synthesis in vitro. II. Age-associated thymosin enhancement of antitetanus antibody synthesis

1984 • 31 citations

Restoration of impaired immune functions in aging animals

1982 • 31 citations

Chromosomes of older humans are more prone to aminopterine-induced breakage.

1989 • 31 citations

Regulation of the immune system by synthetic polynucleotides. VI. Amplification of the immune response in young and aging mice.

1976 • 28 citations

Restoration of impaired immune functions in aging animals. III. Effect of mercaptoethanol in enhancing the reduced primary antibody responsiveness in vivo

1979 • 26 citations

Frequency of 6-thioguanine-resistant T cells is inversely related to the declining T-cell activities in aging mice.

1986 • 26 citations

Changes in NAD levels in human lymphocytes and fibroblasts during aging and in premature aging syndromes

1983 • 25 citations

Model Approach to Immunological Rejuvenation of the Aged

1972 • 24 citations

Nutritional Intervention in the Aging Process

1985 • 23 citations

Synthetic polynucleotides as restorers of normal antibody-forming capacities in aged mice.

1970 • 20 citations

Adenosine deaminase and purine nucleoside phosphorylase activity in spleen cells of aged mice

1980 • 13 citations

Nutritional Intervention During Immunologic Aging: Past and Present

1984 • 12 citations

Electronmicroscopical and immunoelectronmicroscopical examination of the lymphocytes of young and old people after influenza vaccination.

1979 • 5 citations