Inhibition of Signal Transducer and Activator of Transcription 3 (STAT3) Attenuates Interleukin-6 (IL-6)-induced Collagen Synthesis and Resultant Hypertrophy in Rat Heart

Pathological hypertrophy and cardiac interstitium. Fibrosis and renin-angiotensin-aldosterone system.

1991 • 2,017 citations

Determination of hydroxyproline

1967 • 1,583 citations

Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality

1997 • 1,306 citations

Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity

2007 • 727 citations

Interleukin-1β and Tumor Necrosis Factor-α Decrease Collagen Synthesis and Increase Matrix Metalloproteinase Activity in Cardiac Fibroblasts In Vitro

2000 • 486 citations

Inactivation of the Lysyl Oxidase Gene Lox Leads to Aortic Aneurysms, Cardiovascular Dysfunction, and Perinatal Death in Mice

2002 • 465 citations

Cardiac Hypertrophy in Spontaneously Hypertensive Rats

1974 • 458 citations

Interleukin 6 Mediates Myocardial Fibrosis, Concentric Hypertrophy, and Diastolic Dysfunction in Rats

2010 • 396 citations

Involvement of Extracellular Signal-Regulated Kinases 1/2 in Cardiac Hypertrophy and Cell Death

2002 • 387 citations

TNFα in atherosclerosis, myocardial ischemia/reperfusion and heart failure

2010 • 382 citations

Signal Transducer and Activator of Transcription 3 Is Required for Myocardial Capillary Growth, Control of Interstitial Matrix Deposition, and Heart Protection From Ischemic Injury

2004 • 367 citations

Mechanical Stretch Activates the JAK/STAT Pathway in Rat Cardiomyocytes

1999 • 308 citations

B-Type Natriuretic Peptide Exerts Broad Functional Opposition to Transforming Growth Factor-β in Primary Human Cardiac Fibroblasts

2004 • 296 citations

Molecular targets and regulators of cardiac hypertrophy

2009 • 289 citations

Survival pathways in hypertrophy and heart failure: The gp130-STAT3 axis

2007 • 264 citations

Activation of Signal Transducer and Activator of Transcription 3 Protects Cardiomyocytes from Hypoxia/Reoxygenation-Induced Oxidative Stress Through the Upregulation of Manganese Superoxide Dismutase

2001 • 248 citations

Constitutively activated Stat3 protects fibroblasts from serum withdrawal and UV-induced apoptosis and antagonizes the proapoptotic effects of activated Stat1

2001 • 247 citations

Characterization of angiotensin II receptors in cultured adult rat cardiac fibroblasts. Coupling to signaling systems and gene expression.

1994 • 243 citations

Activation of gp130 Transduces Hypertrophic Signals via STAT3 in Cardiac Myocytes

1998 • 238 citations

Interleukin-6 Family of Cytokines Mediate Angiotensin II-induced Cardiac Hypertrophy in Rodent Cardiomyocytes

2000 • 223 citations

Activation of c-Jun N-Terminal Kinases and p38-Mitogen-activated Protein Kinases in Human Heart Failure Secondary to Ischaemic Heart Disease

1999 • 216 citations

Ischemia-induced STAT-1 Expression and Activation Play a Critical Role in Cardiomyocyte Apoptosis

2000 • 208 citations

Proinflammatory cytokines in heart failure: double-edged swords

2010 • 201 citations

The STAT3 inhibitor NSC 74859 is effective in hepatocellular cancers with disrupted TGF-β signaling

2009 • 195 citations

JAK/STAT Signaling Is Associated With Cardiac Dysfunction During Ischemia and Reperfusion

2001 • 189 citations

Nuclear Translocation of Phosphorylated STAT3 Is Essential for Vascular Endothelial Growth Factor-induced Human Dermal Microvascular Endothelial Cell Migration and Tube Formation

2003 • 177 citations

The Dual-Specificity Phosphatase MKP-1 Limits the Cardiac Hypertrophic Response In Vitro and In Vivo

2001 • 163 citations

STAT3 mediates cardioprotection against ischemia/reperfusion injury through metallothionein induction in the heart

2004 • 160 citations

Connective tissue growth factor and cardiac fibrosis

2008 • 157 citations

Role of the JAK–STAT pathway in myocardial injury

2006 • 152 citations

Survival pathways in hypertrophy and heart failure: The gp130-STAT3 axis

2007 • 150 citations

Alterations in Janus Kinase (JAK)-Signal Transducers and Activators of Transcription (STAT) Signaling in Patients With End-Stage Dilated Cardiomyopathy

2003 • 148 citations

Src and Multiple MAP Kinase Activation in Cardiac Hypertrophy and Congestive Heart Failure Under Chronic Pressure-overload: Comparison with Acute Mechanical Stretch

2001 • 144 citations

Arteriolar wall thickening, capillary rarefaction and interstitial fibrosis in the heart of rats with renal failure

1996 • 130 citations

MEK1/2–ERK1/2 Mediates α1-Adrenergic Receptor-stimulated Hypertrophy in Adult Rat Ventricular Myocytes

2001 • 129 citations

Myocardial Fibrosis Associated with Aldosterone or Angiotensin II Administration: Attenuation by Calcium Channel Blockade

1998 • 122 citations

Hypertensive End-Organ Damage and Premature Mortality Are p38 Mitogen-Activated Protein Kinase–Dependent in a Rat Model of Cardiac Hypertrophy and Dysfunction

2001 • 117 citations

Upregulation of lysyl oxidase and MMPs during cardiac remodeling in human dilated cardiomyopathy

2007 • 104 citations

Influence of cytokines and growth factors in ANG II-mediated collagen upregulation by fibroblasts in rats: role of myocytes

2004 • 97 citations

Signal Transducer and Activator of Transcription 1 Activation in Endothelial Cells Is a Negative Regulator of Angiogenesis

2006 • 96 citations

Stress activated protein kinase p38 is involved in IL-6 induced transcriptional activation of STAT3

1999 • 89 citations

Interleukin-13 Induction of 15-Lipoxygenase Gene Expression Requires p38 Mitogen-Activated Protein Kinase-Mediated Serine 727 Phosphorylation of Stat1 and Stat3

2003 • 89 citations

Increased collagen synthesis and decreased collagen degradation in right ventricular hypertrophy induced by pressure overload

1994 • 87 citations

Can the Protective Actions of JAK-STAT in the Heart be Exploited Therapeutically? Parsing the Regulation of Interleukin-6-Type Cytokine Signaling

2007 • 80 citations

Prostaglandin E2 activates Stat3 in neonatal rat ventricular cardiomyocytes: A role in cardiac hypertrophy

2006 • 74 citations

A Role for the Extracellular Signal-regulated Kinase and p38 Mitogen-activated Protein Kinases in Interleukin-1β-stimulated Delayed Signal Tranducer and Activator of Transcription 3 Activation, Atrial Natriuretic Factor Expression, and Cardiac Myocyte Morphology

2001 • 73 citations

Role of Myocytes in Myocardial Collagen Production

2001 • 66 citations

Eccentric cardiac hypertrophy was induced by long‐term intermittent hypoxia in rats

2006 • 58 citations

Analysis of p53 and NF‐κB signaling in modulating the cardiomyocyte fate during hypertrophy

2010 • 51 citations

Angiotensin II and Myocyte Growth

1997 • 46 citations

Myocardial Cell Death and Regeneration during Progression of Cardiac Hypertrophy to Heart Failure

2004 • 43 citations

Parthenolide inhibits STAT3 signaling and attenuates angiotensin II-induced left ventricular hypertrophy via modulation of fibroblast activity

2011 • 42 citations

Inhibition of left ventricular fibrosis by tranilast in rats with renovascular hypertension

2002 • 40 citations

Hypoxia/re-oxygenation-induced, redox-dependent activation of STAT1 (signal transducer and activator of transcription 1) confers resistance to apoptotic cell death via hsp70 induction

2004 • 36 citations

High-Dose Enalapril Treatment Reverses Myocardial Fibrosis in Experimental Uremic Cardiomyopathy

2011 • 35 citations

Determinants of the Cardiomyopathic Phenotype in Chimeric Mice Overexpressing Cardiac Gsα

2000 • 31 citations

Allopurinol Attenuates Oxidative Stress and Cardiac Fibrosis in Angiotensin II‐Induced Cardiac Diastolic Dysfunction

2010 • 29 citations

IL‐17 Eliminates the Therapeutic Effects of Myelin Basic Protein‐Induced Nasal Tolerance in Experimental Autoimmune Encephalomyelitis by Activating IL‐6

2008 • 13 citations