Early diabetes mellitus stimulates proximal tubule renin mRNA expression in the rat

The Effect of Angiotensin-Converting-Enzyme Inhibition on Diabetic Nephropathy

1993 • 5,296 citations

Prevention of diabetic glomerulopathy by pharmacological amelioration of glomerular capillary hypertension.

1986 • 1,210 citations

Angiotensin II stimulates extracellular matrix protein synthesis through induction of transforming growth factor-beta expression in rat glomerular mesangial cells.

1994 • 1,063 citations

Endogenous angiotensin concentrations in specific intrarenal fluid compartments of the rat.

1990 • 421 citations

Angiotensin II-induced hypertrophy of cultured murine proximal tubular cells is mediated by endogenous transforming growth factor-beta.

1993 • 381 citations

Isolation of a pure suspension of rat proximal tubules

1981 • 349 citations

Expression of the Subtype 2 Angiotensin (AT ₂ ) Receptor Protein in Rat Kidney

1997 • 322 citations

Sustained hypersensitivity to angiotensin II and its mechanism in mice lacking the subtype-2 (AT ₂ ) angiotensin receptor

1999 • 316 citations

Renal renin-angiotensin system in diabetes: functional, immunohistochemical, and molecular biological correlations

1993 • 307 citations

Gene expression of the renin-angiotensin system in human tissues. Quantitative analysis by the polymerase chain reaction.

1993 • 244 citations

The role of angiotensin II in diabetic nephropathy: Emphasis on nonhemodynamic mechanisms

1997 • 232 citations

Short- and long-term effect of angiotensin II receptor blockade in rats with experimental diabetes.

1993 • 213 citations

Dietary Na and ACE inhibition effects on renal tissue angiotensin I and II and ACE activity in rats

1992 • 155 citations

Immunohistochemical localization of rat angiotensin II AT1 receptor

1993 • 151 citations

Angiotensin II upregulates type-1 angiotensin II receptors in renal proximal tubule.

1995 • 145 citations

Reduced glomerular angiotensin II receptor density in early untreated diabetes mellitus in the rat

1984 • 141 citations

Role of AT₁angiotensin II receptors in renal ischemic injury

1998 • 121 citations

Cellular localization of AT1 receptor mRNA and protein in normal placenta and its reduced expression in intrauterine growth restriction. Angiotensin II stimulates the release of vasorelaxants.

1998 • 120 citations

Molecular mechanisms of glucose action on angiotensinogen gene expression in rat proximal tubular cells

1999 • 117 citations

Effect of AT₂receptor blockade on the pathogenesis of renal fibrosis

1999 • 114 citations

Renal tubular basement membrane and collagen type IV in diabetes mellitus

1993 • 98 citations

Immunocytochemical localization of renin in mouse kidney

1979 • 93 citations

Reduced Glomerular Angiotensin II Receptor Density in Diabetes Mellitus in the Rat: Time Course and Mechanism*

1987 • 71 citations

STZ-Induced Diabetes Results in Decreased Activity of Glomerular Cathepsin and Metalloprotease in Rats

1993 • 69 citations

Reduced proximal tubule angiotensin II receptor expression in streptozotocin-induced diabetes mellitus

1994 • 68 citations

An Improved Method for Absolute Quantification of mRNA Using Multiplex Polymerase Chain Reaction: Determination of Renin and Angiotensinogen mRNA Levels in Various Tissues

1994 • 64 citations

Alterations of intrarenal renin-angiotensin and nitric oxide systems in streptozotocin-induced diabetic rats.

1997 • 62 citations

Molecular and cellular aspects of renin during kidney ontogeny

1991 • 61 citations

Renal ACE immunohistochemical localization in NIDDM patients with nephropathy

1998 • 58 citations

Angiotensin-Converting Enzyme and Genetic Hypertension: Cloning of Rat cDNAs and Characterization of the Enzyme

1994 • 57 citations

The renin-angiotensin system in streptozotocin-induced diabetes mellitus in the rat.

1993 • 56 citations

Renin and angiotensinogen gene expression in experimental diabetes mellitus

1992 • 56 citations

Expression of growth-related protooncogenes during diabetic renal hypertrophy

1995 • 48 citations

The kidney in streptozotocin diabetic rats. Morphologic, ultrastructural, and function studies.

1976 • 47 citations

Acute renal hemodynamic effects of ACE inhibition in diabetic hyperfiltration: role of kinins

1995 • 44 citations

Tubular cell protein degradation in early diabetic renal hypertrophy.

1994 • 43 citations

Effect of angiotensin II on glomerular hemodynamics and ultrafiltration coefficient.

1987 • 39 citations

Insulin Inhibits Angiotensinogen Gene Expression via the Mitogen-Activated Protein Kinase Pathway in Rat Kidney Proximal Tubular Cells1

1999 • 27 citations

Renin and angiotensinogen expression during the evolution of diabetes.

1992 • 25 citations

In vitro production of angiotensin II by isolated glomeruli

1995 • 21 citations

Effects of UP269-6, a New Angiotensin II Receptor Antagonist, and Captopril on the Progression of Rat Diabetic Nephropathy

1997 • 18 citations