Interferon-Alpha and its Effects on the Cytokine Cascade: A Pro- and Anti-Inflammatory Cytokine

Interleukin-10-deficient mice develop chronic enterocolitis

1993 • 4,225 citations

Virus interference. I. The interferon

1957 • 3,331 citations

Interleukin-10

1993 • 1,820 citations

The Biology of Cachectin/TNF -- A Primary Mediator of the Host Response

1989 • 1,679 citations

Differentiation and proliferation of hematopoietic stem cells

1993 • 1,417 citations

CYTOKINES: COORDINATORS OF IMMUNE AND INFLAMMATORY RESPONSES

1990 • 1,304 citations

Recombinant Interferon Alfa Therapy for Chronic Hepatitis C

1989 • 1,233 citations

Immune response-associated production of neopterin. Release from macrophages primarily under control of interferon-gamma.

1984 • 1,083 citations

The interleukin‐1 family: 10 years of discovery ¹

1994 • 784 citations

Cytokine therapeutics: lessons from interferonalpha.

1994 • 703 citations

Identification of the human 26-kD protein, interferon beta 2 (IFN-beta 2), as a B cell hybridoma/plasmacytoma growth factor induced by interleukin 1 and tumor necrosis factor.

1987 • 690 citations

Purification, cloning, expression and biological characterization of an interleukin-1 receptor antagonist protein

1990 • 609 citations

Interferon alpha increases the frequency of interferon gamma-producing human CD4+ T cells.

1993 • 507 citations

AIDS-Kaposi's Sarcoma-Derived Cells Express Cytokines with Autocrine and Paracrine Growth Effects

1989 • 476 citations

Identification and characterization of an inhibitor of haemopoietic stem cell proliferation

1990 • 470 citations

Chronic myelogenous leukemia: a concise update

1993 • 453 citations

Interferon-Alpha Produces Sustained Cytogenetic Responses in Chronic Myelogenous Leukemia

1991 • 398 citations

Comparative analysis of the influences of human gamma, alpha and beta interferons on human multipotential (CFU-GEMM), erythroid (BFU-E) and granulocyte-macrophage (CFU-GM) progenitor cells.

1983 • 373 citations

Interleukin 1 regulates hematopoietic activity, a role previously ascribed to hemopoietin 1.

1987 • 309 citations

Induction of Type I Diabetes by Interferon-α in Transgenic Mice

1993 • 289 citations

Interleukin 1 receptor antagonist is a member of the interleukin 1 gene family: evolution of a cytokine control mechanism.

1991 • 243 citations

Studies of interferon as a regulator of hematopoietic cell proliferation.

1985 • 195 citations

Interleukin 1 induces expression of the human immunodeficiency virus alone and in synergy with interleukin 6 in chronically infected U1 cells: inhibition of inductive effects by the interleukin 1 receptor antagonist.

1994 • 188 citations

Downregulation of interleukin 8 gene expression in human fibroblasts: unique mechanism of transcriptional inhibition by interferon.

1992 • 184 citations

Immune-mediated and unusual complications during interferon alfa therapy in chronic myelogenous leukemia.

1995 • 175 citations

Effect of recombinant interferons alpha and gamma on human bone marrow- derived megakaryocytic progenitor cells

1987 • 173 citations

A bone marrow stromal-derived growth factor, interleukin-11, stimulates recovery of small intestinal mucosal cells after cytoablative therapy

1994 • 161 citations

Peptide Growth Factors and Their Receptors II

1990 • 142 citations

Induction of circulating IL-1 receptor antagonist by IFN treatment.

1993 • 137 citations

Interleukin‐1 regulation of hematopoietic growth factor production by human stromal fibroblasts

1988 • 136 citations

Successful treatment of metastatic renal cell carcinoma with a biologically active dose of recombinant interferon-gamma.

1989 • 134 citations

IL-1 induces IL-1. IV. IFN-gamma suppresses IL-1 but not lipopolysaccharide-induced transcription of IL-1.

1990 • 128 citations

Interferon-α Stimulates the Hypothalamic- Pituitary-Adrenal Axis in vivo and in vitro

1993 • 110 citations

ALPHA-INTERFERON THERAPY FOR ESSENTIAL THROMBOCYTHAEMIA

1988 • 108 citations

IL-1 and transforming growth factor-beta regulation of fibroblast-derived IL-11.

1994 • 99 citations

Tumour necrosis factor (TNF) binding proteins (soluble TNF receptor forms) with possible roles in inflammation and malignancy.

1993 • 98 citations

Regulation of cytokine expression by interferon-alpha in human bone marrow stromal cells: inhibition of hematopoietic growth factors and induction of interleukin-1 receptor antagonist

1994 • 94 citations

Type-I interferons are potent inhibitors of interleukin-8 production in hematopoietic and bone marrow stromal cells

1993 • 91 citations

Expression of stem cell factor and c-kit mRNA in cultured endothelial cells, monocytes and cloned human bone marrow stromal cells (CFU-RF).

1992 • 88 citations

Interferon-alpha induces circulating tumor necrosis factor receptor p55 in humans

1995 • 71 citations

Interleukin 1 Induces HIV-1 Expression in Chronically Infected U1 Cells: Blockade by Interleukin 1 Receptor Antagonist and Tumor Necrosis Factor Binding Protein Type 1

1995 • 65 citations

The Use of Interferon-α in Virus Infections

1991 • 63 citations

A new treatment for polycythemia vera: recombinant interferon alfa [see comments]

1990 • 53 citations

Type 1 Interferon as an Antiinflammatory Agent: Inhibition of Lipopolysaccharide-Induced Interleukin-lβ and Induction of Interleukin-1 Receptor Antagonist

1995 • 52 citations

Type I interferons (IFN-α and -β) suppress cytotoxin (tumor necrosis factor-α and lymphotoxin) production by mitogen-stimulated human peripheral blood mononuclear cells

1992 • 51 citations

Regulation of interleukin (IL)-11 gene expression in IL-1 induced primate bone marrow stromal cells

1994 • 48 citations

Retinal complications with elevated circulating plasma C5a associated with interferon-alpha therapy for chronic active hepatitis C.

1994 • 46 citations

Mechanism of action of α interferon in chronic granulocytic leukaemia: evidence for preferential inhibition of late progenitors

1989 • 44 citations

Down-regulation of intercellular adhesion molecule 1 on hepatocytes in viral chronic hepatitis treated with interferon alfa-2b

1993 • 41 citations

Interferon‐α prevents endotoxin‐induced mortality in mice

1992 • 41 citations

Differential regulation of stem cell factor mRNA expression in human endothelial cells by bacterial pathogens: an in vitro model of inflammation

1994 • 39 citations

Alpha-Interferon: Differential Suppression of Colony Growth from Human Erythroid, Myeloid, and Megakaryocytic Hematopoietic Progenitor Cells

1986 • 37 citations

The effects of interferon‐α on the proliferation of CML progenitor cells in vitro are not related to the precise position of the M‐BCR breakpoint

1991 • 31 citations

Proliferation of myeloid progenitor cells in human long-term bone marrow cultures is stimulated by interleukin-1 beta

1988 • 29 citations

Inhibition of interleukin-11 by interferon-alpha in human bone marrow stromal cells.

1996 • 24 citations

Biologic activity of low dosage IL-2 treatment in vivo. Molecular assessment of cytokine network interaction.

1994 • 23 citations

Both type I and type II interferons down‐regulate human tumor necrosis factor receptors in human hepatocellular carcinoma cell line Hep G2

1994 • 21 citations

Recombinant interferon-alpha-2C in chronic myelogenous leukaemia: Relationship of sensitivity of committed haematopoietic precursor cells in vitro (BFU-E, CFU-GM, CFU-Meg) and clinical response

1990 • 20 citations

Production of Hepatitis B Virus by Stably Transfected Monocytic Cell Line U-937: A Model for Extrahepatic Hepatitis B Virus Replication

1992 • 15 citations

Immunomodulatory agents and other medical therapies in inflammatory bowel disease

1995 • 14 citations

Biotherapy of chronic myelogenous leukemia

1995 • 14 citations

Divergent in vivo and in vitro antileukemic activity of recombinant interferon beta in patients with chronic-phase chronic myelogenous leukemia

1993 • 13 citations

Interferons

1990 • 12 citations

Interferons 1992

1992 • 10 citations

Use of Recombinant Interferons and Hematopoietic Growth Factors in Patients Infected with Human Immunodeficiency Virus

1991 • 8 citations

Autocrine loop of tumor necrosis factor induced by interferon-alpha in tumor cells from hairy cell leukemia.

1995 • 7 citations