The role of lipid peroxidation in liver damage

Lysosomes in biology and pathology

1977 • 2,068 citations

Free Radical Mechanisms in Tissue Injury

1988 • 1,585 citations

ADVANCES IN LIPID RESEARCH

1966 • 1,199 citations

Identification of 4-hydroxynonenal as a cytotoxic product originating from the peroxidation of liver microsomal lipids

1980 • 1,094 citations

Evidence that Peroxidation of Lysosomal Membranes Is Initiated by Hydroxyl Free Radicals Produced during Flavin Enzyme Activity

1973 • 663 citations

Separation and characterization of the aldehydic products of lipid peroxidation stimulated by ADP-Fe2+ in rat liver microsomes

1982 • 614 citations

Naturally occurring carbonyl compounds are mutagens Salmonella tester strain TA104

1985 • 596 citations

Lipid peroxidation and cellular damage in toxic liver injury.

1985 • 556 citations

Chemicals, Drugs, and Lipid Peroxidation

1976 • 520 citations

Structure and function of phospholiphase A2

1981 • 478 citations

Necrogenic Action of Carbon Tetrachloride in the Rat: A Speculative Mechanism Based on Activation

1966 • 457 citations

Separation and characterization of the aldehydic products of lipid peroxidation stimulated by carbon tetrachloride or ADP-iron in isolated rat hepatocytes and rat liver microsomal suspensions

1985 • 362 citations

Hydroperoxide‐Metabolizing Systems in Rat Liver

1975 • 266 citations

Organic hydroperoxide-induced lipid peroxidation and cell death in isolated hepatocytes

1985 • 265 citations

Modification of human low-density lipoprotein by the lipid peroxidation product 4-hydroxynonenal

1986 • 241 citations

Cadmium toxicity and lipid peroxidation in isolated rat hepatocytes

1980 • 231 citations

Drug-induced lipid peroxidation in mice—I Modulation by monooxegenase activity, glutathione and selenium status

1981 • 222 citations

Protective role of the glutathione redox cycle against adriamycin-mediated toxicity in isolated hepatocytes

1981 • 221 citations

Hydroperoxide-induced loss of pyridine nucleotides and release of calcium from rat liver mitochondria.

1980 • 220 citations

A Correlation between Glutathione Levels and Cellular Damage in Isolated Hepatocytes

1977 • 204 citations

Endogenous defenses against the cytotoxicity of hydrogen peroxide in cultured rat hepatocytes.

1985 • 196 citations

Depletion in vitro of mitochondrial glutathione in rat hepatocytes and enhancement of lipid peroxidation by adriamycin and 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU)

1983 • 177 citations

Effects of lipid peroxidation on membrane-bound enzymes of the endoplasmic reticulum

1971 • 173 citations

Mechanisms of the killing of cultured hepatocytes by hydrogen peroxide

1984 • 172 citations

Differential effect of lipid peroxidation on membrane fluidity as determined by electron spin resonance probes

1983 • 165 citations

Liver glutathione depletion induced by bromobenzene, iodobenzene, and diethylmaleate poisoning and its relation to lipid peroxidation and necrosis.

1985 • 159 citations

Lipid Peroxidation of Rat‐Liver Microsomes

1973 • 156 citations

Lipid peroxidation in ethanol poisoning: a critical reconsideration.

1985 • 153 citations

Critical role of lipid peroxidation in carbon tetrachloride-induced loss of aminopyrine demethylase, cytochrome P-450 and glucose 6-phosphatase

1976 • 151 citations

Cytotoxic aldehydes originating from the peroxidation of liver microsomal lipids

1984 • 150 citations

Microsomal lipid peroxidation causes an increase in the order of the membrane lipid domain

1982 • 145 citations

Formation of hydroxyl radicals in the presence of ferritin and haemosiderin. Is haemosiderin formation a biological protective mechanism?

1986 • 145 citations

Uncoupling of oxidative phosphorylation in mitochondria from fatty livers

1954 • 137 citations

Cellular toxicity and lipid peroxidation in response to mercury

1982 • 136 citations

Mechanisms of cell injury in the killing of cultured hepatocytes by bromobenzene.

1982 • 135 citations

Pyridine‐nucleotide oxidation, Ca²⁺ cycling and membrane damage during tert‐butyl hydroperoxide metabolism by rat‐liver mitochondria

1984 • 135 citations

Role of redox cycling and lipid peroxidation in bipyridyl herbicide cytotoxicity

1986 • 133 citations

Vitamin E Reversal of the Effect of Extracellular Calcium on Chemically Induced Toxicity in Hepatocytes

1985 • 132 citations

Effects of diffusible products of peroxidation of rat liver microsomal lipids

1979 • 131 citations

Studies on fatty liver with isolated hepatocytes

1979 • 126 citations

Hepatic mitochondrial oxidative metabolism in rats with chronic dietary iron overload

1985 • 125 citations

Destruction of liver microsomal calcium pump activity by carbon tetrachloride and bromotrichloromethane

1981 • 123 citations

The role of acrolein in allyl alcohol-induced lipid peroxidation and liver cell damage in mice

1987 • 122 citations

No chemical evidence of hepatic lipid peroxidation in acute ethanol toxicity

1968 • 121 citations

Lipid peroxidation of rat liver microsomes

1980 • 118 citations

Mechanisms underlying calcium homeostasis in isolated hepatocytes.

1983 • 118 citations

Lipid Peroxidation in Isolated Hepatocytes

1975 • 118 citations

Effect of CCl-4 in vitro and in vivo on lipid peroxidation of rat liver homogenates and subcellular fractions.

1965 • 116 citations

Comparison of the effects of metals on cellular injury and lipid peroxidation in isolated rat hepatocytes

1981 • 116 citations

Effects of 4-hydroxynonenal on adenylate cyclase and 5′-nucleotidase activities in rat liver plasma membranes

1985 • 114 citations

Lipid peroxidation increases the molecular order of microsomal membranes

1984 • 111 citations

Inhibition of the ethanol and carbon tetrachloride induced fatty liver by antioxidants

1965 • 111 citations

Increase in cytosolic Ca²⁺ concentration during t‐butyl hydroperoxide metabolism by isolated hepatocytes involves NADPH oxidation and mobilization of intracellular Ca²⁺ stores

1984 • 107 citations

Inhibition of lipid peroxidation without prevention of cellular injury in isolated rat hepatocytes

1981 • 106 citations

Effect of in vivo and in vitro ethanol administration on liver lipid peroxidation.

1967 • 103 citations

Dissociation of cell death from covalent binding of paracetamol by flavones in a hepatocyte system

1982 • 98 citations

Ethane production and liver necrosis in rats after administration of drugs and other chemicals

1979 • 95 citations

Characterization of iron-mediated peroxidative injury in isolated hepatic lysosomes.

1985 • 93 citations

THE EFFECT OF ANTIOXIDANTS ON POISONING BY CARBON TETRACHLORIDE

1962 • 79 citations

Structural changes in microsomal suspensions

1965 • 78 citations

Detection of carbonyl functions in phospholipids of liver microsomes in CCl4- and BrCCl3-poisoned rats

1982 • 75 citations

Involvement of cytochrome P-450 in the intracellular formation of lipid peroxides

1975 • 73 citations

The role of lipid peroxidation in CCl4-induced damage to liver microsomal enzymes: Comparative studies in vitro using microsomes and isolated liver cells

1981 • 71 citations

The role of lipid peroxidation in the toxicity of foreign compounds to liver cells

1983 • 71 citations

Self-catalysed, O2-independent inactivation of nadph- or dithionite-reduced microsomal cytochrome P-450 by carbon tetrachloride

1981 • 70 citations

Comparison of the Inactivation of Microsomal Glucose-6-Phosphatase by in Situ Lipid Peroxidation-Derived 4-Hydroxynonenal and Exogenous 4-Hydroxynonenal

1986 • 70 citations

Studies on fatty liver with isolated hepatocytes

1977 • 68 citations

On the mechanism of carbon tetrachloride hepatotoxicity: Co-incidence of loss of glucose-6-phosphatase activity with peroxidation of microsomal lipid

1965 • 66 citations

Effects of Oxidative Stress Caused by Hyperoxia and Diquat. A Study in Isolated Hepatocytes

1986 • 64 citations

Detection of 4-hydroxynonenal and other lipid peroxidation products in the liver of bromobenzene-poisoned mice

1986 • 62 citations

The Consequences of Lipid Peroxidation in Isolated Hepatocytes

1975 • 61 citations

Effects of carbon tetrachloride on isolated rat hepatocytes. Inhibition of protein and lipoprotein secretion

1979 • 59 citations

Ethanol‐induced hepatotoxicity; experimental observations on the role of lipid peroxidation

1978 • 57 citations

The effect of primary products of lipid peroxidation on the transmembrane transport of calcium ions

1982 • 57 citations

Carbon tetrachloride and bromotrichloromethane toxicity

1983 • 56 citations

The role of lipid peroxidation in the induction of cation transport in rat liver mitochondria

1983 • 55 citations

The metabolism of halothane by hepatocytes: A comparison between free radical spin trapping and lipid peroxidation in relation to cell damage

1983 • 51 citations

Analytical subcellular fractionation of needle-biopsy specimens from human liver

1978 • 50 citations

Inhibition of calcium sequestration activity of liver microsomes by 4-hydroxyalkenals originating from the peroxidation of liver microsomal lipids

1984 • 48 citations

tert–butylhydroperoxide—Induced toxicity in isolated hepatocytes: Contribution of thiol oxidation and lipid peroxidation

1986 • 48 citations

Chloroform-induced glutathione depletion and toxicity in freshly isolated hepatocytes

1980 • 42 citations

Mechanisms responsible for carbon tetrachloride‐induced perturbation of mitochondrial calcium homeostasis

1985 • 42 citations

Carbon tetrachloride-dependent inhibition of lipid secretion by isolated hepatocytes characterization and requirement for bioactivation

1984 • 41 citations

The effect of ferric iron complex on isolated rat liver mitochondria. I. Respiratory and electrochemical responses

1985 • 37 citations

Cytotoxic effects of paraquat and inhibition of them by vitamin E

1986 • 36 citations

Carbon tetrachloride-induced inhibition of hepatocyte lipoprotein secretion: Functional impairment of Golgi apparatus in the early phases of such injury

1985 • 34 citations

Toxicity of 1,2-dibromoethane in isolated hepatocytes: Role of lipid peroxidation

1984 • 34 citations

Studies on the relationships between carbon tetrachloride-induced alterations of liver microsomal lipids and impairment of glucose-6-phosphatase activity

1977 • 32 citations

Activities of Some Free-Radical Scavenging Enzymes and Glutathione Concentrations in Human and Rat Liver and their Relationship to the Pathogenesis of Tissue Damage in Iron Overload

1980 • 30 citations

Lipid peroxidation and cell damage in isolated hepatocytes due to bromotrichloromethane

1978 • 30 citations

Influence of lipid peroxidation on lipoprotein secretion by isolated hepatocytes

1981 • 28 citations

Protection of rat hepatocytes from tert-butyl hydroperoxide-induced injury by catechol

1986 • 28 citations

Ultrastructural and biochemical changes induced by progressive lipid peroxidation on isolated microsomes and rat liver endoplasmic reticulum.

1980 • 25 citations

Evidence for increased membrane permeability of plasmalemmal vesicles from livers of phenobarbital-induced CCl4-intoxicated rats.

1986 • 24 citations

Influence of acute ethanol intoxication on rat liver Golgi apparatus glycosylation activities

1978 • 23 citations

4-Hydroxy-alkenals interaction with purified microtubular protein

1985 • 23 citations

The effect of whole-body x-irradiation on the distribution of acid deoxyribonuclease and beta-galactosidase in subcellular fractions of rat spleen.

1963 • 21 citations

Biochemical aspects of the protective action of propyl gallate on liver injury in rats poisoned with carbon tetrachloride

1975 • 20 citations

Rat liver microsomal phospholipase A2 and membrane fluidity

1986 • 19 citations

Alcohol and alcoholism

1981 • 18 citations

Biochemical evidence for chemical and/or topographic differences in the lipoperoxidative processes induced by CCl4 and iron

1983 • 17 citations

The Effect of Whole-Body X-Irradiation on the Distribution of Acid Deoxyribonuclease and β-Galactosidase in Subcellular Fractions of Rat Spleen

1963 • 16 citations

Early alterations induced by carbon tetrachloride in the lipids of the membranes of the endoplasmic reticulum of the liver cell II. Distribution of the alterations in the various lipid fractions

1977 • 16 citations

In vitro evidence for CCl₄ metabolites covalently bound to lipoprotein micelles

1983 • 15 citations

Studies on fatty liver with isolated hepatocytes

1984 • 13 citations

Studies on lipid peroxidation using whole liver cells: Influence of damaged cells on the prooxidant effect of ADP-Fe3+ and CCl4

1981 • 13 citations

Correlations between common tests for assessment of liver damage: Indices of the hepatoprotective activity of promethazine in carbon tetrachloride hepatotoxicity

1983 • 13 citations

Thiobarbituric reacting substance(s) produced in normal liver fractions

1964 • 12 citations

The effect of various aldehydes on the respiration of rat liver and hepatoma AH‐130 cells

1985 • 11 citations

Inhibition of Liver Golgi Glycosylation Activities by Carbonyl Products of Lipid

1987 • 10 citations

Effect of drug pretreatment on CBrCl3-induced liver injury

1974 • 9 citations

Killing of cultured hepatocytes by the mixed-function oxidation of ethoxycoumarin

1986 • 9 citations

Deleted Work

1955 • 0 citations