Angiotensin II and its receptors in the diabetic kidney

The Effect of Intensive Treatment of Diabetes on the Development and Progression of Long-Term Complications in Insulin-Dependent Diabetes Mellitus

1993 • 23,535 citations

The Effect of Angiotensin-Converting-Enzyme Inhibition on Diabetic Nephropathy

1993 • 5,296 citations

Prevention of diabetic glomerulopathy by pharmacological amelioration of glomerular capillary hypertension.

1986 • 1,210 citations

Therapeutic advantage of converting enzyme inhibitors in arresting progressive renal disease associated with systemic hypertension in the rat.

1986 • 1,071 citations

Angiotensin II stimulates extracellular matrix protein synthesis through induction of transforming growth factor-beta expression in rat glomerular mesangial cells.

1994 • 1,063 citations

The angiotensin AT2-receptor mediates inhibition of cell proliferation in coronary endothelial cells.

1995 • 918 citations

Effects on blood pressure and exploratory behaviour of mice lacking angiotensin II type-2 receptor

1995 • 858 citations

Expression cloning of type 2 angiotensin II receptor reveals a unique class of seven-transmembrane receptors.

1993 • 767 citations

Direct stimulation of Jak/STAT pathway by the angiotensin II AT1 receptor

1995 • 737 citations

Angiotensin II type 1 receptor gene polymorphisms in human essential hypertension.

1994 • 731 citations

Molecular cloning of a novel angiotensin II receptor isoform involved in phosphotyrosine phosphatase inhibition.

1993 • 713 citations

Angiotensin II type 2 receptor mediates programmed cell death.

1996 • 707 citations

The angiotensin II type 2 (AT2) receptor antagonizes the growth effects of the AT1 receptor: gain-of-function study using gene transfer.

1995 • 688 citations

Angiotensin II-forming pathways in normal and failing human hearts.

1990 • 585 citations

Angiotensin II regulates the expression of plasminogen activator inhibitor-1 in cultured endothelial cells. A potential link between the renin-angiotensin system and thrombosis.

1995 • 539 citations

Effect of captopril on progression to clinical proteinuria in patients with insulin-dependent diabetes mellitus and microalbuminuria. European Microalbuminuria Captopril Study Group

1994 • 494 citations

The subtype 2 (AT2) angiotensin receptor mediates renal production of nitric oxide in conscious rats.

1997 • 481 citations

Long-term renoprotective effect of angiotensin-converting enzyme inhibition in non-insulin-dependent diabetes mellitus. A 7-year follow-up study

1996 • 443 citations

Endogenous angiotensin concentrations in specific intrarenal fluid compartments of the rat.

1990 • 421 citations

Angiotensin II effects upon the glomerular microcirculation and ultrafiltration coefficient of the rat.

1976 • 414 citations

Contraction of Cultured Rat Glomerular Cells of Apparent Mesangial Origin after Stimulation with Angiotensin II and Arginine Vasopressin

1980 • 400 citations

Angiotensin II-induced hypertrophy of cultured murine proximal tubular cells is mediated by endogenous transforming growth factor-beta.

1993 • 381 citations

Dose-dependent stimulation and inhibition of proximal tubular sodium reabsorption by angiotensin II in the rat kidney

1977 • 368 citations

Relationships Between Angiotensin I Converting Enzyme Gene Polymorphism, Plasma Levels, and Diabetic Retinal and Renal Complications

1994 • 361 citations

Effect of Captopril on Progression to Clinical Proteinuria in Patients With Insulin-Dependent Diabetes Mellitus and Microalbuminuria

1994 • 353 citations

Angiotensin II stimulates the proliferation and biosynthesis of type I collagen in cultured murine mesangial cells.

1992 • 332 citations

In situ hybridization evidence for angiotensinogen messenger RNA in the rat proximal tubule. An hypothesis for the intrarenal renin angiotensin system.

1990 • 325 citations

Expression of the Subtype 2 Angiotensin (AT ₂ ) Receptor Protein in Rat Kidney

1997 • 322 citations

Reduced growth, abnormal kidney structure, and type 2 (AT ₂ ) angiotensin receptor-mediated blood pressure regulation in mice lacking both AT _1A and AT _1B receptors for angiotensin II

1998 • 316 citations

Sustained hypersensitivity to angiotensin II and its mechanism in mice lacking the subtype-2 (AT ₂ ) angiotensin receptor

1999 • 316 citations

Effects of converting enzyme inhibitors on angiotensin and bradykinin peptides.

1994 • 315 citations

The subtype-2 (AT2) angiotensin receptor regulates renal cyclic guanosine 3', 5'-monophosphate and AT1 receptor-mediated prostaglandin E2 production in conscious rats.

1996 • 311 citations

Renal renin-angiotensin system in diabetes: functional, immunohistochemical, and molecular biological correlations

1993 • 307 citations

Long-term Renoprotective Effect of Angiotensin-converting Enzyme Inhibition in Non—insulin-dependent Diabetes Mellitus

1996 • 297 citations

Distribution of angiotensin AT₁and AT₂receptor subtypes in the rat kidney

1999 • 273 citations

The Paradox of the Low-Renin State in Diabetic Nephropathy

1999 • 270 citations

Angiotensin II stimulates expression of the chemokine RANTES in rat glomerular endothelial cells. Role of the angiotensin type 2 receptor.

1997 • 255 citations

Immunohistochemical localization of ANG II AT1 receptor in adult rat kidney using a monoclonal antibody

1997 • 254 citations

Protective Role of the Angiotensin AT ₂ Receptor in a Renal Wrap Hypertension Model

1999 • 241 citations

Angiotensin II Type 2 Receptor Is Upregulated in Human Heart With Interstitial Fibrosis, and Cardiac Fibroblasts Are the Major Cell Type for Its Expression

1998 • 241 citations

Differential regulation of angiotensin peptide levels in plasma and kidney of the rat.

1991 • 240 citations

Angiotensin II type 2 receptors mediate inhibition of mitogen-activated protein kinase cascade and functional activation of SHP-1 tyrosine phosphatase

1997 • 225 citations

Short- and long-term effect of angiotensin II receptor blockade in rats with experimental diabetes.

1993 • 213 citations

Angiotensin II induces cellular hypertrophy in cultured murine proximal tubular cells

1990 • 211 citations

Angiotensin II modulates cell growth-related events and synthesis of matrix proteins in renal interstitial fibroblasts

1997 • 208 citations

Angiotensin II stimulates early proximal bicarbonate absorption in the rat by decreasing cyclic adenosine monophosphate.

1989 • 201 citations

Role of angiotensin II in glucose-induced inhibition of mesangial matrix degradation.

1999 • 200 citations

Effective Postponement of Diabetic Nephropathy With Enalapril in Normotensive Type 2 Diabetic Patients With Microalbuminuria

1997 • 199 citations

Bradykinin causes selective efferent arteriolar dilation during angiotensin I converting enzyme inhibition

1993 • 197 citations

Receptor-Mediated Intrarenal Angiotensin II Augmentation in Angiotensin II–Infused Rats

1996 • 193 citations

Tubular fluid concentrations and kidney contents of angiotensins I and II in anesthetized rats.

1994 • 190 citations

Elevated plasma atrial natriuretic peptide levels in diabetic rats. Potential mediator of hyperfiltration.

1987 • 188 citations

Lack of Relationship Between an Insertion/Deletion Polymorphism in the Angiotensin I–Converting Enzyme Gene and Diabetic Nephropathy and Proliferative Retinopathy in IDDM Patients

1995 • 187 citations

Association of ACE gene polymorphism and diabetic nephropathy?

1995 • 180 citations

Impact of Hyperglycemia on the Renin Angiotensin System in Early Human Type 1 Diabetes Mellitus

1999 • 179 citations

Possible role of P-450 metabolite of arachidonic acid in vasodilator mechanism of angiotensin II type 2 receptor in the isolated microperfused rabbit afferent arteriole.

1997 • 172 citations

Accelerated fibrosis and collagen deposition develop in the renal interstitium of angiotensin type 2 receptor null mutant mice during ureteral obstruction Rapid Communication

1998 • 170 citations

Correlation of receptor sequestration with sustained diacylglycerol accumulation in angiotensin II-stimulated cultured vascular smooth muscle cells.

1987 • 161 citations

The paradox of the renin-angiotensin system in chronic renal disease

1994 • 156 citations

Renin-angiotensin blockade lowers MCP-1 expression in diabetic rats

1999 • 154 citations

Angiotensin II Stimulates the Synthesis and Secretion of Vascular Permeability Factor/Vascular Endothelial Growth Factor in Human Mesangial Cells

1999 • 153 citations

Regulation of extracellular matrix by mechanical stress in rat glomerular mesangial cells.

1996 • 150 citations

Effects of combination therapy with enalapril and losartan on the rate of progression of renal injury in rats with 5/6 renal mass ablation.

1998 • 149 citations

Increase in serum prorenin precedes onset of microalbuminuria in patients with insulin-dependent diabetes mellitus

1999 • 146 citations

Angiotensin II upregulates type-1 angiotensin II receptors in renal proximal tubule.

1995 • 145 citations

Reduced glomerular angiotensin II receptor density in early untreated diabetes mellitus in the rat

1984 • 141 citations

Synthesis and effects of active fragments of angiotensin II

1997 • 139 citations

Subtype 2 of angiotensin II receptors controls pressure-natriuresis in rats.

1995 • 138 citations

Additive Effects of Losartan and Enalapril on Blood Pressure and Plasma Active Renin

1997 • 131 citations

Angiotensin II type 1 receptor gene polymorphism predicts response to losartan and angiotensin II

1999 • 126 citations

Effect of angiotensin II and norepinephrine on isolated rat afferent and efferent arterioles

1990 • 126 citations

The AT2 Receptor Selectively Associates with Giα2 and Giα3 in the Rat Fetus

1996 • 123 citations

Angiotensin II stimulates human fetal mesangial cell proliferation and fibronectin biosynthesis by binding to AT1 receptors

1994 • 123 citations

An epoxygenase metabolite of arachidonic acid mediates angiotensin II-induced rises in cytosolic calcium in rabbit proximal tubule epithelial cells.

1991 • 122 citations

Molecular mechanisms of glucose action on angiotensinogen gene expression in rat proximal tubular cells

1999 • 117 citations

Effect of AT₂receptor blockade on the pathogenesis of renal fibrosis

1999 • 114 citations

Endogenous production of angiotensin II modulates rat proximal tubule transport.

1996 • 114 citations

Platelet-derived growth factor and angiotensin II stimulate the mitogen-activated protein kinase cascade in renal mesangial cells: comparison of hypertrophic and hyperplastic agonists

1995 • 114 citations

Gene expression of the renin-angiotensin system in human kidney

1998 • 112 citations

Mechanical stretch/relaxation of cultured rat mesangial cells induces protooncogenes and cyclooxygenase

1994 • 112 citations

Expansion of Cortical Interstitium Is Limited by Converting Enzyme Inhibition in Type 2 Diabetic Patients with Glomerulosclerosis

1999 • 108 citations

The Cardiac Renin-Angiotensin System in STZ-Induced Diabetes

1994 • 106 citations

Combination ACE Inhibitor and Angiotensin II Receptor Antagonist Therapy in Diabetic Nephropathy

1999 • 105 citations

Two distinct pathways in the down-regulation of type-1 angiotensin II receptor gene in rat glomerular mesangial cells

1992 • 104 citations

Angiotensin-Converting Enzyme Is Upregulated in the Proximal Tubules of Rats With Intense Proteinuria

1999 • 101 citations

Abnormal water metabolism in mice lacking the type 1A receptor for ANG II

2000 • 100 citations

Angiotensin II stimulates interleukin-6 release from cultured mouse mesangial cells.

1995 • 100 citations

Effect of Hyperglycaemia on Arterial Pressure, Plasma Renin Activity and Renal Function in Early Diabetes

1996 • 98 citations

Angiotensin II Signaling in Vascular Smooth Muscle Cells Under High Glucose Conditions

1999 • 98 citations

Molecular biology and signaling of angiotensin receptors: an overview.

1999 • 97 citations

Angiotensin II stimulates expression of transforming growth factor β receptor type II in cultured mouse proximal tubular cells

1999 • 94 citations

Association analyses of the polymorphisms of angiotensin-converting enzyme and angiotensinogen genes with diabetic nephropathy in Japanese non-insulin-dependent diabetics

1996 • 89 citations

Endothelin modulates angiotensin II-induced mitogenesis of human mesangial cells

1993 • 88 citations

Renal hemodynamics and plasma and kidney angiotensin II in established diabetes mellitus in rats

1995 • 86 citations

Temperature-sensitive SV40 immortalized rat proximal tubule cell line has functional renin-angiotensin system

1995 • 86 citations

Angiotensin II Is Mitogenic for Cultured Rat Glomerular Endothelial Cells

1996 • 83 citations

Genetic variants of the renin-angiotensin system, diabetic nephropathy and hypertension

1997 • 78 citations

The intrarenal renin-angiotensin system.

1993 • 78 citations

Hyperglycemia Enhances Angiotensin II-induced Janus-activated Kinase/STAT Signaling in Vascular Smooth Muscle Cells

1999 • 77 citations

Intracellular signaling of transcription and secretion of type IV collagen after angiotensin II-induced cellular hypertrophy in cultured proximal tubular cells.

1991 • 77 citations

A Molecular Variant of Angiotensinogen Is Associated With Diabetic Nephropathy in IDDM

1996 • 77 citations

Endothelin stimulates PDGF secretion in cultured human mesangial cells

1990 • 76 citations

The intrarenal renin-angiotensin system

1993 • 74 citations

Characterization and distribution of angiotensin II receptor subtypes in the mouse brain

1998 • 74 citations

Angiotensin stimulates bicarbonate transport and Na+/K+ ATPase in rat proximal straight tubules.

1991 • 74 citations

Role of bradykinin-NO pathway in prevention of cardiac hypertrophy by ACE inhibitor in rat cardiomyocytes

1997 • 73 citations

Role of angiotensin II in dietary modulation of rat late distal tubule bicarbonate flux in vivo.

1996 • 72 citations

Angiotensin-Converting Enzyme Polymorphism and Development of Diabetic Nephropathy in Non-Insulin-Dependent Diabetes mellitus

1995 • 72 citations

Reduced Glomerular Angiotensin II Receptor Density in Diabetes Mellitus in the Rat: Time Course and Mechanism*

1987 • 71 citations

Angiotensin II Receptor Type 1 Gene Expression in Human Glomerulonephritis and Diabetes Mellitus

1999 • 71 citations

Reduced proximal tubule angiotensin II receptor expression in streptozotocin-induced diabetes mellitus

1994 • 68 citations

Biphasic effect of angiotensin II on intracellular sodium concentration in rat proximal tubules

1995 • 67 citations

Mechanical Stretch/Relaxation Stimulates a Cellular Renin-Angiotensin System in Cultured Rat Mesangial Cells

1998 • 67 citations

Evaluation of risk factors for the development of nephropathy in patients with IDDM: insertion/deletion angiotensin converting enzyme gene polymorphism, hypertension and metabolic control

1997 • 66 citations

Angiotensinogen Gene Polymorphisms in IDDM Patients With Diabetic Nephropathy

1996 • 66 citations

Renin and renin mRNA in proximal tubules of the rat kidney.

1994 • 65 citations

Regulation of luminal alkalinization and acidification in the cortical collecting duct by angiotensin II

1995 • 64 citations

Alterations of intrarenal renin-angiotensin and nitric oxide systems in streptozotocin-induced diabetic rats.

1997 • 62 citations

Restoration of tubuloglomerular feedback in volume-expanded rats by angiotensin II

1990 • 61 citations

Tissue-specific changes in angiotensin II receptors in streptozotocin-diabetic rats

1997 • 60 citations

Synergistic effect of angiotensin II type 1 receptor genotype and poor glycaemic control on risk of nephropathy in IDDM

1997 • 59 citations

Angiotensin II-stimulated hypertrophy of LLC-PK1 cells depends on the induction of the cyclin-dependent kinase inhibitor p27Kip1

1996 • 58 citations

Renal ACE immunohistochemical localization in NIDDM patients with nephropathy

1998 • 58 citations

Plasma renin and prorenin and renin gene variation in patients with insulin-dependent diabetes mellitus and nephropathy

1999 • 58 citations

The renin-angiotensin system in streptozotocin-induced diabetes mellitus in the rat.

1993 • 56 citations

Renin and angiotensinogen gene expression in experimental diabetes mellitus

1992 • 56 citations

Angiotensin II signalling events mediated by tyrosine phosphorylation

1996 • 56 citations

Increased bradykinin and “normal” angiotensin peptide levels in diabetic Sprague-Dawley and transgenic (mRen-2)27 rats

1999 • 54 citations

Effect of luminal angiotensin II on proximal tubule fluid transport: role of apical phospholipase A2

1994 • 54 citations

Angiotensin II inhibits growth of cultured embryonic renomedullary interstitial cells through the AT2 receptor

1998 • 53 citations

Downregulation of the renin-angiotensin system in streptozotocin-diabetic rats

1992 • 52 citations

Glomerulopathy in Spontaneously Diabetic Rat: Impact of Glycemic Control

1987 • 51 citations

Angiotensinogen Polymorphism M235T, Hypertension, and Nephropathy in Insulin-Dependent Diabetes

1996 • 51 citations

Angiotensin I converting enzyme and kinin–hydrolyzing enzymes along the rabbit nephron

1987 • 49 citations

The subtype 2 angiotensin receptor regulates renal prostaglandin F2 alpha formation in conscious rats

1997 • 48 citations

The renin-angiotensin system in the type II diabetic obese Zucker rat.

1993 • 48 citations

Differential regulation of angiotensin II and losartan binding sites in glomeruli and mesangial cells

1994 • 47 citations

Effects of diabetes and insulin on expression of kallikrein and renin genes in the kidney

1992 • 46 citations

Angiotensin II modulates cellular functions of podocytes

1998 • 45 citations

Angiotensin (AT_1A) receptor-mediated increases in transcellular sodium transport in proximal tubule cells

1998 • 44 citations

Prevention of Renal Injury in Diabetic MWF Rats by Angiotensin II Antagonism

1998 • 43 citations

Physiologic Actions and Molecular Expression of the Renin-Angiotensin System in the Diabetic Rat

1998 • 42 citations

In vivo modulation of rat distal tubule net HCO3 flux by VIP, isoproterenol, angiotensin II, and ADH

1994 • 41 citations

Regulation of angiotensin II receptors and PKC isoforms by glucose in rat mesangial cells

1999 • 41 citations

ANG II is a mitogen for a murine cell line isolated from medullary thick ascending limb of Henle's loop

1995 • 39 citations

Changes in Blood Pressure, Body Fluids, Circulating Angiotensin II and Aldosterone, with Improved Diabetic Control

1982 • 35 citations

Regulation of Na+/H+ exchange by diadenosine polyphosphates, angiotensin II, and vasopressin in rat cortical collecting duct.

1995 • 35 citations

Effect of glucose on the expression of the angiotensinogen gene in opossum kidney cells

1998 • 34 citations

Renin-angiotensin system and prostacyclin biosynthesis in streptozotocin diabetic rats

1983 • 33 citations

High glucose augments angiotensin II action by inhibiting NO synthesis in in vitro microperfused rabbit afferent arterioles

1995 • 33 citations

Enhanced renal sensitivity to angiotensin actions in diabetes mellitus in the rat

1996 • 32 citations

Localization and Functional Properties of Angiotensin II AT1 Receptors in the Kidney. Focus on Renomedullary Interstitial Cells.

1997 • 31 citations

Interactions of the Kallikrein-Kinin and Renin-Angiotensin Systems in Experimental Diabetes

1997 • 31 citations

The subtype 2 of angiotensin II receptors and pressure‐natriuresis in adult rat kidneys

1999 • 30 citations

Effects of Specific Antagonists of Angiotensin II Receptors and Captopril on Diabetic Nephropathy in Mice.

1997 • 28 citations

Influence of Dietary Sodium Restriction on Angiotensin II Receptors in Rat Adrenals*

1997 • 28 citations

Regulation of S6 kinase activity in renal proximal tubule

1992 • 27 citations

Renin and angiotensinogen expression during the evolution of diabetes.

1992 • 25 citations

Immortalized rabbit cortical collecting duct cells express AT1 angiotensin II receptors

1996 • 23 citations

In vitro production of angiotensin II by isolated glomeruli

1995 • 21 citations

Effects of UP269-6, a New Angiotensin II Receptor Antagonist, and Captopril on the Progression of Rat Diabetic Nephropathy

1997 • 18 citations

Reduced activity of renal angiotensin-converting enzyme in streptozotocin-induced diabetic rats

1991 • 17 citations

Reduced Renal Microvascular Reactivity to Angiotensin II in Diabetic Rats

1994 • 16 citations

Alteration of cytosolic calcium induced by angiotensin II and norepinephrine in mesangial cells from diabetic rats

1997 • 16 citations

Hyperreninemia due to increased renal renin synthesis in BioBreeding Worcester rats.

1990 • 9 citations

Vascular reactivity to angiotensin II in blood-perfused kidneys of hypertensive diabetic rats

1996 • 8 citations

ABNORMALITY OF THE GLOMERULAR ANGIOTENSIN II RECEPTOR IN EXPERIMENTAL DIABETIC NEPHROPATHY

1993 • 5 citations

Association analyses of the polymorphisms of the angiotensin converting enzyme and angiotensinogen genes with diabetic nephropathy in Japanese non-insulin-dependent diabetics

1996 • 1 citations