The paradox of the renin-angiotensin system in chronic renal disease

Hyperfiltration in remnant nephrons: a potentially adverse response to renal ablation

1981 • 1,664 citations

Isolation of a cDNA encoding the vascular type-1 angiotensin II receptor

1991 • 1,247 citations

Prevention of diabetic glomerulopathy by pharmacological amelioration of glomerular capillary hypertension.

1986 • 1,210 citations

Therapeutic advantage of converting enzyme inhibitors in arresting progressive renal disease associated with systemic hypertension in the rat.

1986 • 1,071 citations

Control of glomerular hypertension limits glomerular injury in rats with reduced renal mass.

1985 • 931 citations

Cloning and expression of a complementary DNA encoding a bovine adrenal angiotensin II type-1 receptor

1991 • 808 citations

Glomerular hemodynamics in experimental diabetes mellitus

1981 • 785 citations

Morphology, physiology, and molecular biology of renin secretion

1990 • 610 citations

Effect of antihypertensive treatment on kidney function in diabetic nephropathy.

1987 • 551 citations

Pathophysiology of chronic tubulo-interstitial disease in rats. Interactions of dietary acid load, ammonia, and complement component C3.

1985 • 482 citations

Renal protective effect of enalapril in diabetic nephropathy.

1992 • 437 citations

Effect of Captopril on Heavy Proteinuria in Azotemic Diabetics

1985 • 430 citations

Endogenous angiotensin concentrations in specific intrarenal fluid compartments of the rat.

1990 • 421 citations

Beneficial effects of angiotensin converting enzyme inhibition on renal function in patients with diabetic nephropathy.

1986 • 415 citations

Angiotensin II effects upon the glomerular microcirculation and ultrafiltration coefficient of the rat.

1976 • 414 citations

Efficacy and variability of the antiproteinuric effect of ACE inhibition by lisinopril

1989 • 363 citations

Association between blood pressure and the rate of decline in renal function with age

1984 • 362 citations

Effect of captopril on kidney function in insulin-dependent diabetic patients with nephropathy.

1986 • 313 citations

Short and long term effects of antihypertensive therapy in the diabetic rat

1989 • 310 citations

Effects of angiotensin II and vasopressin on human smooth muscle cells in vitro

1981 • 306 citations

Prevalence and Pathologic Features of Sickle Cell Nephropathy and Response to Inhibition of Angiotensin-Converting Enzyme

1992 • 290 citations

Segmental effects of norepinephrine and angiotensin II on isolated renal microvessels

1983 • 281 citations

Long-term comparison between captopril and nifedipine in the progression of renal insufficiency

1992 • 273 citations

Reversing glomerular hypertension stabilizes established glomerular injury

1987 • 269 citations

Converting enzyme inhibition and kidney function in normotensive diabetic patients with persistent microalbuminuria.

1987 • 261 citations

Angiotensin converting enzyme inhibition ameliorates glomerular filtration of macromolecules and water and lessens glomerular injury in the rat.

1990 • 255 citations

Reduction of proteinuria by angiotensin converting enzyme inhibition

1987 • 220 citations

Angiotensin II induces cellular hypertrophy in cultured murine proximal tubular cells

1990 • 211 citations

RENIN SECRETION IN RENAL HYPERTENSION

1970 • 196 citations

[Sar1]angiotensin II receptor-mediated stimulation of protein synthesis in chick heart cells

1990 • 188 citations

EGF-induced mitogenesis in proximal tubular cells: potentiation by angiotensin II

1987 • 182 citations

Renin and angiotensinogen gene expression and intrarenal renin distribution during ACE inhibition

1988 • 169 citations

Effects of Diltiazem or Lisinopril on Massive Proteinuria Associated with Diabetes Mellitus

1990 • 167 citations

Angiotensin Converting Enzyme Inhibitors and Progressive Renal Insufficiency

1989 • 158 citations

Prostaglandins and renin release: II. Assessment of renin secretion following infusion of PGI2, E2 and D2 into the renal artery of anesthetized dogs

1978 • 157 citations

Molecular biology of the renin-angiotensin system

1988 • 156 citations

Oxygen consumption and oxidant stress in surviving nephrons

1990 • 150 citations

Progression of chronic renal failure in man is retarded with more frequent clinical follow-ups and better blood pressure control.

1986 • 147 citations

Reduced glomerular angiotensin II receptor density in early untreated diabetes mellitus in the rat

1984 • 141 citations

Synthesis of renin by tubulocystic epithelium in autosomal-dominant polycystic kidney disease

1992 • 138 citations

Contrasting effects of enalapril and metoprolol on proteinuria in diabetic nephropathy.

1990 • 131 citations

Mechanisms underlying transition from acute glomerular injury to late glomerular sclerosis in a rat model of nephrotic syndrome.

1988 • 130 citations

Effect of angiotensin II and norepinephrine on isolated rat afferent and efferent arterioles

1990 • 126 citations

The anatomy of the renin-secreting cell in adult polycystic kidney disease

1988 • 121 citations

Comparison of the renal effects of angiotensin converting enzyme inhibitor and calcium antagonist in hypertensive Type 2 (non-insulin-dependent) diabetic patients with microalbuminuria: a randomised controlled trial

1989 • 120 citations

Effect of antihypertensive treatment on progression of incipient diabetic nephropathy.

1985 • 116 citations

Angiotensin II receptor-mediated proliferation of cultured human fetal mesangial cells

1991 • 113 citations

Renin and angiotensinogen gene expression in maturing rat kidney

1988 • 112 citations

Serial micropuncture analysis of single nephron function in subtotal renal ablation

1988 • 105 citations

The intrarenal renin-angiotensin-system

1982 • 95 citations

Converting Enzyme Inhibition in Chronic Renal Failure

1989 • 93 citations

Irreversible tubulointerstitial damage associated with chronic aminonucleoside nephrosis. Amelioration by angiotensin I converting enzyme inhibition.

1990 • 91 citations

Evidence for the Local Occurrence of Angiotensin II in Rat Kidney and its Modulation by Dietary Sodium Intake and Converting Enzyme Blockade

1979 • 87 citations

Relationship among altered glomerular barrier permselectivity, angiotensin II, and mesangial uptake of macromolecules.

1985 • 86 citations

Progressive glomerular injury after limited renal infarction in the rat

1988 • 86 citations

Comparative Effect of Captopril and Nifedipine in Normotensive Patients With Incipient Diabetic Nephropathy

1988 • 84 citations

Regulation of glomerular filtration rate and sodium excretion by angiotensin II.

1986 • 78 citations

Renal vascular effects of antihypertensive therapy in uninephrectomized SHR

1989 • 76 citations

A Randomized, Double-Blind, Placebo-Controlled Trial to Evaluate the Effect of Enalapril in Patients With Clinical Diabetic Nephropathy

1992 • 71 citations

Reduced Glomerular Angiotensin II Receptor Density in Diabetes Mellitus in the Rat: Time Course and Mechanism*

1987 • 71 citations

Use of a specific antiserum for renin detection in human kidney.

1980 • 69 citations

Induction of hypertrophy in cultured proximal tubule cells by extracellular NH4Cl.

1989 • 64 citations

Effect of prostanoids on renin release from rabbit afferent arterioles with and without macula densa

1989 • 64 citations

Angiotensin II control of the renal microcirculation in rats with reduced renal mass

1990 • 62 citations

Captopril Treatment of Hypertension and Renal Failure in Systemic <i>Lupus erythematosus</i>

1984 • 59 citations

Renin expression in renal ablation.

1992 • 59 citations

OBSERVATIONS ON THE SIMILARITY OF MESANGIAL TO JUXTAGLOMERULAR CELLS.

1963 • 57 citations

Prostaglandin and Thromboxane Formation in Glomeruli from Rats with Reduced Renal Mass

1986 • 56 citations

Regulatory role of prostanoids in glomerular microcirculation of remnant nephrons

1987 • 56 citations

Effects of varying sodium intake on blood pressure and renin-angiotensin system in subtotally nephrectomized rats.

1976 • 54 citations

Renal metabolism of angiotensin I and II.

1990 • 53 citations

Anatomy of the renin‐angiotensin system in the normal and pathological kidney

1986 • 51 citations

Glomerular renin synthesis and storage in the remnant kidney in the rat

1991 • 51 citations

Use of Angiotensin-Converting Enzyme Inhibitors for the Preservation of Kidney Function

1990 • 48 citations

Regulation of Deoxyribonucleic Acid Synthesis in Bovine Adrenocortical Cells in Culture*

1979 • 47 citations

Angiotensin II stimulates ammoniagenesis in canine renal proximal tubule segments

1991 • 42 citations

Effect of converting enzyme inhibitors on tissue converting enzyme and angiotensin II: Therapeutic implications

1987 • 41 citations

Superficial nephron responses to peritubular capillary infusions of angiotensins I and II

1987 • 39 citations

Effect of angiotensin II and norepinephrine on early growth response genes in the rat kidney

1993 • 38 citations

Glomerular angiotensinase A in the rat: Increase of enzyme activity following renal ablation

1990 • 34 citations

Distribution and content of renin and renin mRNA in remnant kidney of adult rat

1992 • 32 citations

Comparative Effects of Antihypertensives on Proteinuria: Angiotensin-Converting Enzyme Inhibitor Versus α1-Antagonist

1991 • 31 citations

Identification and regulation of renin in human cultured mesangial cells

1987 • 28 citations

The distribution of renin‐containing cells in kidneys with renal artery stenosis—an immunocytochemical study

1990 • 27 citations

Renin localization in segmental renal hypoplasia

1981 • 25 citations

Intrarenal metabolism of angiotensin II

1990 • 25 citations

Angiotensin II receptor regulation in anti-glomerular basement membrane nephritis

1990 • 21 citations

Comparative effect of captopril and nifedipine in normotensive patients with incipient diabetic nephropathy.

1988 • 21 citations

Hemodynamic changes during the development of sodium–induced hypertension in subtotally nephrectomized rats

1979 • 20 citations

Serum angiotensin converting enzyme activity in patients with chronic renal failure on long term hemodialysis

1979 • 15 citations

The renin‐secreting cell in polyarteritis—an immunocytochemical study

1990 • 15 citations

Immunohistochemical Localization of Renin in End-Stage Kidneys

1988 • 14 citations

Renin-positive granulated Goormaghtigh cells

1989 • 14 citations

Chronic pyelonephritis: The significance of renal renin and the vascular changes in the human kidney

1991 • 11 citations

Quantitation of glomerular angiotensin II receptors in IgA nephropathy.

1989 • 10 citations

Comparison of Residual Glomerular Function in Experimental Papillary Necrosis and Renal Infarction

1990 • 5 citations

Deleted Work

1955 • 0 citations