Evaluation of risk factors for the development of nephropathy in patients with IDDM: insertion/deletion angiotensin converting enzyme gene polymorphism, hypertension and metabolic control

An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels.

1990 • 3,809 citations

Deletion polymorphism in the gene for angiotensin-converting enzyme is a potent risk factor for myocardial infarction

1992 • 1,956 citations

Evidence, from combined segregation and linkage analysis, that a variant of the angiotensin I-converting enzyme (ACE) gene controls plasma ACE levels.

1992 • 1,181 citations

The Stages in Diabetic Renal Disease: With Emphasis on the Stage of Incipient Diabetic Nephropathy

1983 • 940 citations

A Prospective Evaluation of an Angiotensin-Converting–Enzyme Gene Polymorphism and the Risk of Ischemic Heart Disease

1995 • 920 citations

Association between a Deletion Polymorphism of the Angiotensin-Converting-Enzyme Gene and Left Ventricular Hypertrophy

1994 • 757 citations

Glycosylated Hemoglobin and the Risk of Microalbuminuria in Patients with Insulin-Dependent Diabetes Mellitus

1995 • 460 citations

Epidemiologic Approach to the Etiology of Type I Diabetes Mellitus and Its Complications

1987 • 416 citations

Relationships Between Angiotensin I Converting Enzyme Gene Polymorphism, Plasma Levels, and Diabetic Retinal and Renal Complications

1994 • 361 citations

Plasma level and gene polymorphism of angiotensin-converting enzyme in relation to myocardial infarction.

1994 • 263 citations

Converting enzyme inhibition and kidney function in normotensive diabetic patients with persistent microalbuminuria.

1987 • 261 citations

Lack of Relationship Between an Insertion/Deletion Polymorphism in the Angiotensin I–Converting Enzyme Gene and Diabetic Nephropathy and Proliferative Retinopathy in IDDM Patients

1995 • 187 citations

Angiotensin converting enzyme insertion/deletion polymorphism

1994 • 179 citations

Comparison of reduction in microalbuminuria by enalapril and hydrochlorothiazide in normotensive patients with insulin dependent diabetes.

1993 • 81 citations

Lack of relationship between an insertion/deletion polymorphism in the angiotensin I-converting enzyme gene and diabetic nephropathy and proliferative retinopathy in IDDM patients

1995 • 55 citations

Systemic hypertension and the renin-angiotensin system in diabetic vascular complications

1993 • 34 citations

Mechanisms of Diabetic Nephropathy

1994 • 31 citations

Angiotensin-converting enzyme polymorphism in patients with terminal renal failure.

1996 • 30 citations

Acute Sodium Loading in Patients with Uncomplicated Diabetes Mellitus: Renal and Hormonal Effects

1994 • 12 citations

Cardiovascular and hormonal responses to cold pressor test in insulin-dependent diabetic adolescents with microalbuminuria

1994 • 7 citations