Ret in human development and oncogenesis

The Protein Kinase Family: Conserved Features and Deduced Phylogeny of the Catalytic Domains

1988 • 5,115 citations

Cadherin Cell Adhesion Receptors as a Morphogenetic Regulator

1991 • 3,314 citations

Germ-line mutations of the RET proto-oncogene in multiple endocrine neoplasia type 2A

1993 • 1,941 citations

Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret

1994 • 1,589 citations

Mutations in the RET proto-oncogene are associated with MEN 2A and FMTC

1993 • 1,273 citations

Renal and neuronal abnormalities in mice lacking GDNF

1996 • 1,260 citations

Renal agenesis and the absence of enteric neurons in mice lacking GDNF

1996 • 1,208 citations

Defects in enteric innervation and kidney development in mice lacking GDNF

1996 • 1,169 citations

A mutation in the RET proto-oncogene associated with multiple endocrine neoplasia type 2B and sporadic medullary thyroid carcinoma

1994 • 1,140 citations

Characterization of a multicomponent receptor for GDNF

1996 • 1,086 citations

Targeted and natural (piebald-lethal) mutations of endothelin-B receptor gene produce megacolon associated with spotted coat color in mice

1994 • 1,000 citations

PTC is a novel rearranged form of the ret proto-oncogene and is frequently detected in vivo in human thyroid papillary carcinomas

1990 • 949 citations

Interaction of endothelin-3 with endothelin-B receptor is essential for development of epidermal melanocytes and enteric neurons

1994 • 934 citations

Catalytic specificity of protein-tyrosine kinases is critical for selective signalling

1995 • 929 citations

A missense mutation of the endothelin-B receptor gene in multigenic hirschsprung's disease

1994 • 886 citations

Expression of the c-ret proto-oncogene during mouse embryogenesis

1993 • 831 citations

Activation of RET as a Dominant Transforming Gene by Germline Mutations of MEN2A and MEN2B

1995 • 826 citations

GDNF signalling through the Ret receptor tyrosine kinase

1996 • 809 citations

Activation of a novel human transforming gene, ret, by DNA rearrangement

1985 • 796 citations

Functional receptor for GDNF encoded by the c-ret proto-oncogene

1996 • 795 citations

Mutations of the RET proto-oncogene in Hirschsprung's disease

1994 • 751 citations

Point mutations affecting the tyrosine kinase domain of the RET proto-oncogene in Hirschsprung's disease

1994 • 702 citations

Specific mutations of the RET proto-oncogene are related to disease phenotype in MEN 2A and FMTC

1994 • 646 citations

The neurocristopathiesA unifying concept of disease arising in neural crest maldevelopment

1974 • 591 citations

Single missense mutation in the tyrosine kinasecatalytic domain of the RET protooncogene is associated with multiple endocrineneoplasia type 2B.

1994 • 591 citations

Mutation of the endothelin-3 gene in the Waardenburg-Hirschsprung disease (Shah-Waardenburg syndrome)

1996 • 449 citations

A linked genetic marker for multiple endocrine neoplasia type 2A on chromosome 10

1987 • 440 citations

A genetic study of Hirschsprung disease.

1990 • 426 citations

Assignment of multiple endocrine neoplasia type 2A to chromosome 10 by linkage

1987 • 423 citations

Molecular characterization of RET/PTC3; a novel rearranged version of the RETproto-oncogene in a human thyroid papillary carcinoma.

1994 • 364 citations

ret transforming gene encodes a fusion protein homologous to tyrosine kinases.

1987 • 346 citations

Mechanism of Activation of the ret Proto-oncogene by Multiple Endocrine Neoplasia 2A Mutations

1995 • 336 citations

A homozygous mutation in the endothelin-3 gene associated with a combined Waardenburg type 2 and Hirschsprung phenotype (Shah-Waardenburg syndrome)

1996 • 303 citations

Embryogenesis of intramural ganglia of the gut and its relation to Hirschsprung's disease

1967 • 281 citations

Germline mutations in glial cell line-derived neurotrophic factor (GDNF) and RET in a Hirschsprung disease patient

1996 • 277 citations

Genotype‐phenotype correlation in multiple endocrine neoplasia type 2: report of the International RET Mutation Consortium

1995 • 272 citations

A novel point mutation in the tyrosine kinase domain of the RET proto-oncogene in sporadic medullary thyroid carcinoma and in a family with FMTC.

1995 • 253 citations

Diverse phenotypes associated with exon 10 mutations of the RET proto-oncogene

1994 • 246 citations

Mutation analysis of the RET receptor tyrosine kinase in Hirschsprung disease

1995 • 243 citations

Molecular Characterization of a Thyroid Tumor-Specific Transforming Sequence Formed by the Fusion of ret Tyrosine Kinase and the Regulatory Subunit RIα of Cyclic AMP-Dependent Protein Kinase A

1993 • 239 citations

The ret proto-oncogene is consistently expressed in human pheochromocytomas and thyroid medullary carcinomas.

1990 • 233 citations

Mutation of the endothelin-receptor B gene in Waardenburg-Hirschsprung disease

1995 • 227 citations

Parent-of-origin effects in multiple endocrine neoplasia type 2B.

1994 • 224 citations

RET mutations in exons 13 and 14 of FMTC patients.

1995 • 220 citations

Loss of function effect of RET mutations causing Hirschsprung disease

1995 • 218 citations

Heterozygous endothelin receptor B (EDNRB) mutations in isolated Hirschsprung disease

1996 • 209 citations

Germline mutations of the RET ligand GDNF are not sufficient to cause Hirschsprung disease

1996 • 194 citations

A gene for Hirschsprung disease maps to the proximal long arm of chromosome 10

1993 • 190 citations

RISK ESTIMATION AND SCREENING IN FAMILIES OF PATIENTS WITH MEDULLARY THYROID CARCINOMA

1988 • 181 citations

Characterization of ret proto-oncogene mRNAs encoding two isoforms of the protein product in a human neuroblastoma cell line.

1990 • 181 citations

Mutations in the RET proto-oncogene and the von Hippel-Lindau disease tumour suppressor gene in sporadic and syndromic phaeochromocytomas.

1995 • 171 citations

Molecular characterization of a thyroid tumor-specific transforming sequence formed by the fusion of ret tyrosine kinase and the regulatory subunit RI alpha of cyclic AMP-dependent protein kinase A.

1993 • 168 citations

A gene for Hirschsprung disease (megacolon) in the pericentromeric region of human chromosome 10

1993 • 157 citations

cDNA cloning of mouse ret proto-oncogene and its sequence similarity to the cadherin superfamily.

1993 • 155 citations

Novel mutations of the endothelin-B receptor gene in isolated patients with Hirschsprung's disease

1996 • 141 citations

Analysis ofRET protooncogene point mutations distinguishes heritable from nonheritable medullary thyroid carcinomas

1995 • 136 citations

Genetic events in tumour initiation and progression in multiple endocrine neoplasia type 2

1993 • 134 citations

Molecular heterogeneity of RET loss of function in Hirschsprung's disease.

1996 • 132 citations

Isolation of ret proto-oncogene cDNA with an amino-terminal signal sequence.

1989 • 130 citations

RET activation by germline MEN2A and MEN2B mutations.

1995 • 130 citations

Expression of the ret proto‐oncogene product in human normal and neoplastic tissues of neural crest origin

1994 • 126 citations

An epidermal growth factor receptor/ret chimera generates mitogenic and transforming signals: evidence for a ret-specific signaling pathway

1994 • 102 citations

The physical map of the human RET proto-oncogene.

1995 • 96 citations

Close linkage with the RET protooncogene and boundaries of deletion mutations in autosomal dominant Hirschsprung disease

1993 • 93 citations

Localisation of the gene for multiple endocrine neoplasia type 2A to a 480 kb region in chromosome band 10q11.2

1993 • 91 citations

Total colonic aganglionosis associated with interstitial deletion of the long arm of chromosome 10

1992 • 84 citations

Heterogeneity and Low Detection Rate of RET Mutations in Hirschsprung Disease

1994 • 67 citations

The human protooncogene ret: a communicative cadherin?

1992 • 62 citations

An epidermal growth factor receptor/ret chimera generates mitogenic and transforming signals: evidence for a ret-specific signaling pathway.

1994 • 59 citations

Mutations in the RET protooncogene in sporadic pheochromocytomas.

1995 • 57 citations

Hirschsprung's disease associated with a deletion of chromosome 10 (q11.2q21.2): a further link with the neurocristopathies?

1994 • 56 citations

Identification and analysis of the ret proto-oncogene promoter region in neuroblastoma cell lines and medullary thyroid carcinomas from MEN2A patients.

1992 • 50 citations

Multiple endocrine neoplasia: How many syndromes?

1990 • 45 citations

Hirschsprung's disease in the newborn

1986 • 43 citations

Multiple mRNA isoforms of the human RET proto-oncogene generated by alternate splicing.

1995 • 41 citations

Two maternally derived missense mutations in the tyrosine kinase domain of the RET protooncogene in a patient with de novo MEN 2B

1995 • 40 citations

Mutations in the RET protooncogene in sporadic pheochromocytomas

1995 • 17 citations

The high transforming potency of erbB-2 and ret is associated with phosphorylation of paxillin and a 23 kDa protein.

1994 • 15 citations