The Blood-brain Barrier: Principles for Targeting Peptides and Drugs to the Central Nervous System

Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites.

1989 • 1,744 citations

The spontaneous insertion of proteins into and across membranes: The helical hairpin hypothesis

1981 • 868 citations

Relationship of octanol/water partition coefficient and molecular weight to rat brain capillary permeability

1980 • 799 citations

Electrical resistance across the blood‐brain barrier in anaesthetized rats: a developmental study.

1990 • 736 citations

Passage of peptides through the blood-brain barrier with colloidal polymer particles (nanoparticles)

1995 • 528 citations

Development of a new physicochemical model for brain penetration and its application to the design of centrally acting H2 receptor histamine antagonists

1988 • 514 citations

Anti-transferrin receptor antibody and antibody-drug conjugates cross the blood-brain barrier.

1991 • 385 citations

Lipid Solubility and Drug Penetration of the Blood Brain Barrier

1974 • 372 citations

Polarity of the Blood-Brain Barrier: Neutral Amino Acid Transport into Isolated Brain Capillaries

1978 • 335 citations

Selective transport of an anti-transferrin receptor antibody through the blood-brain barrier in vivo.

1991 • 323 citations

Blood-Brain Barrier Penetration and in Vivo Activity of an NGF Conjugate

1993 • 316 citations

Peptide Drug Delivery to the Brain

1992 • 309 citations

Hydrogen Bonding. 33. Factors That Influence the Distribution of Solutes between Blood and Brain

1994 • 296 citations

P-glycoprotein as the drug efflux pump in primary cultured bovine brain capillary endothelial cells

1992 • 288 citations

Glycopeptide enkephalin analogues produce analgesia in mice: evidence for penetration of the blood-brain barrier.

1994 • 243 citations

Developmental changes in transferrin and iron uptake by the brain in the rat

1990 • 219 citations

PEPTIDES WITH AFFINITY FOR MEMBRANES

1987 • 179 citations

Advances in drug research

1990 • 168 citations

Restricted transport of cyclosporin A across the blood-brain barrier by a multidrug transporter, P-glycoprotein

1993 • 157 citations

Effects of Bradykinin on Permeability and Diameter of Pial Vessels In vivo

1984 • 152 citations

Importance of secondary structure in the signal sequence for protein secretion.

1983 • 152 citations

Analgesic activity of the hexapeptide dalargin adsorbed on the surface of polysorbate 80-coated poly(butyl cyanoacrylate) nanoparticles

1995 • 151 citations

Characterization of an "in vitro" blood-brain barrier: effects of molecular size and lipophilicity on cerebrovascular endothelial transport rates of drugs.

1988 • 139 citations

Transport of Leucine‐Enkephalin Across the Blood‐Brain Barrier in the Perfused Guinea Pig Brain

1987 • 120 citations

Permeability of the murine blood-brain barrier to some octapeptide analogs of somatostatin.

1990 • 103 citations

Kinetics of arginine-vasopressin uptake at the blood-brain barrier

1990 • 98 citations

Rate of ⁵⁹Fe Uptake into Brain and Cerebrospinal Fluid and the Influence Thereon of Antibodies Against the Transferrin Receptor

1993 • 90 citations

Kinetic Analysis of Leucine-Enkephalin Cellular Uptake at the Luminal Side of the Blood-Brain Barrier of an In Situ Perfused Guinea-Pig Brain

1989 • 86 citations

Carrier-mediated transport of baclofen across monolayers of bovine brain endothelial cells in primary culture.

1988 • 86 citations

Inhibition of Penicillin Transport from the Cerebrospinal Fluid after Intracisternal Inoculation of Bacteria

1974 • 82 citations

Ventriculo–cisternal perfusion of twelve amino acids in the rabbit

1982 • 64 citations

Biologically stable analogues of trh with increased neuropharmacological potency

1981 • 55 citations

Thyrotropin releasing hormone

1984 • 53 citations

A mechanism for P-glycoprotein action in multidrug resistance: are we there yet?

1994 • 50 citations

Ultrastructure of Brain Endothelium

1992 • 46 citations

Chapter 21: Bidirectional passage of peptides across the blood-brain barrier

1992 • 40 citations

A guide to the clinical use of the somatostatin analogue SMS 201-995 (Sandostatin)

1987 • 31 citations

Drug Entry Into the Brain and Its Pharmacologic Manipulation

1992 • 29 citations

Chapter 24: The interaction of some centrally active drugs with the blood-brain barrier and circumventricular organs

1992 • 29 citations

Strategies for delivery of peptide drugs to the central nervous system: exploiting molecular structure

1994 • 26 citations

Peptides and the Blood-Brain Barrier

1992 • 24 citations

Therapeutic Opening of the Blood-Brain Barrier in Man

1992 • 14 citations

Transport of encephalins from the cerebrospinal fluid of the rabbit

1988 • 9 citations

Mechanisms Regulating Peptide Levels in the Cerebrospinal Fluid

1992 • 7 citations

Central long-lasting analgesic effect of RC-160, an analog of somatosiatin

1990 • 3 citations