Therapeutic Opening of the Blood-Brain Barrier in Man

Karnofsky performance status revisited: reliability, validity, and guidelines.

1984 • 1,412 citations

Mouse monoclonal IgG3 antibody detecting GD3 ganglioside: a phase I trial in patients with malignant melanoma.

1985 • 566 citations

Primary CNS lymphoma treated with osmotic blood-brain barrier disruption: prolonged survival and preservation of cognitive function.

1991 • 379 citations

Intrathecal chemotherapy: brain tissue profiles after ventriculocisternal perfusion.

1975 • 321 citations

Implications of the Blood-Brain Barrier and Its Manipulation

1989 • 308 citations

Therapeutic Efficacy of Multiagent Chemotherapy with Drug Delivery Enhancement by Blood-Brain Barrier Modification in Glioblastoma

1986 • 166 citations

Reversible Osmotic Blood-Brain Barrier Disruption in Humans

1980 • 163 citations

Absence of contrast enhancement on CT brain scans of patients with supratentorial malignant gliomas

1988 • 153 citations

Successful treatment of recurrent primary central nervous system lymphoma with high-dose methotrexate

1980 • 132 citations

Developments in the diagnosis and treatment of primary CNS lymphoma: A prospective series

1986 • 123 citations

Osmotic blood-brain barrier disruption and chemotherapy in the treatment of high grade malignant glioma: patient series and literature review

1992 • 123 citations

Ocular and Orbital Toxicity Following Intracarotid Injection of BCNU (Carmustine) and Cisplatinum for Malignant Gliomas

1985 • 86 citations

Regional Blood Flow and Blood-to-Tissue Transport in Five Brain Tumor Models

2015 • 78 citations

Growth of human lung tumor in the brain of the nude rat as a model to evaluate antitumor agent delivery across the blood-brain barrier.

1985 • 73 citations

Increased Delivery of Tumor-specific Monoclonal Antibodies to Brain after Osmotic Blood-Brain Barrier Modification in Patients with Melanoma Metastatic to the Central Nervous System

1987 • 67 citations

Maculopathy Associated With Combination Chemotherapy and Osmotic Opening of the Blood-Brain Barrier

1986 • 65 citations

46 CONTRAST ENHANCED MRI

1985 • 60 citations

Osmotic blood-brain barrier disruption in the posterior fossa of the dog

1981 • 58 citations

Osmotic blood-brain barrier modification: clinical documentation by enhanced CT scanning and/or radionuclide brain scanning

1983 • 55 citations

Chemotherapy administered in conjunction with osmotic blood-brain barrier modification in patients with brain metastases

1987 • 49 citations

Chemotherapeutic Agent Permeability to Normal Brain and Delivery to Avian Sarcoma Virus-induced Brain Tumors in the Rodent: Observations on Problems of Drug Delivery

1984 • 45 citations

Immunoreactivity assay for labeled anti-melanoma monoclonal antibodies.

1986 • 44 citations

Blood-Brain Barrier Disruption in the Treatment of Brain Tumors

1989 • 43 citations

Further Studies with a Noninvasive Method of Intracranial Pressure Estimation

1984 • 42 citations

Therapy of Malignant Brain Tumors

1986 • 42 citations

Contrast Enhanced MRI

1985 • 38 citations

Intra-arterial ACNU Chemotherapy Employing 20% Mannitol Osmotic Blood-brain Barrier Disruption for Malignant Brain Tumors

1990 • 34 citations

Intracarotid Chemotherapy with 1,3-Bis-(2-chloroethyl)-1-nitrosourea (BCNU) in 5% Dextrose in Water in the Treatment of Malignant Glioma

1987 • 32 citations

Intracarotid Chemotherapy of Glioblastoma after Induced Blood-Brain Barrier Disruption

1983 • 26 citations

Intra-arterial chemotherapy of malignant gliomas.

1988 • 17 citations

Methotrexate Disposition Following Disruption of the Blood-Brain Barrier

1991 • 17 citations

Principles of Chemotherapy in Brain Neoplasia

1987 • 17 citations

Intra-arterial chemotherapy by cisplatin and cytarabine after temporary disruption of the blood-brain barrier for the treatment of malignant gliomas in adults.

1986 • 10 citations

[ACNU delivery to malignant glioma tissue by osmotic blood brain barrier modification with intracarotid infusion of hyperosmoral mannitol].

1985 • 9 citations

Ocular complication of combined intracarotid chemotherapy and osmotic blood-brain barrier disruption.

1985 • 7 citations

[Blood-brain barrier opening microcirculation in human brain tumor].

1985 • 6 citations

[Intra-arterial chemotherapy of malignant glioma after osmotic blood-brain barrier disruption].

1989 • 6 citations

[Hemodynamic effects of an osmotic bolus for the reversible opening of the blood-brain barrier].

1987 • 5 citations

Anesthetic management during therapeutic disruption of the blood-brain barrier.

1986 • 4 citations

Bacterial and Fungal Brain Abscess and the Blood-Brain Barrier

1989 • 3 citations

Radiotherapy and chemotherapy of malignant brain gliomas.

1986 • 3 citations

[Reversible opening of the blood-brain barrier in the chemotherapy of malignant gliomas].

1987 • 3 citations