Reduction of human monocytic cell neurotoxicity and cytokine secretion by ligands of the cannabinoid‐type CB2 receptor

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

1983 • 52,849 citations

A Simple Sequentially Rejective Multiple Test Procedure

1979 • 20,726 citations

Amyloid Oligomers Exacerbate Tau Pathology in a Mouse Model of Tauopathy

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Molecular characterization of a peripheral receptor for cannabinoids

1993 • 4,950 citations

Inflammation and Alzheimer's disease

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Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill

1989 • 3,477 citations

International Union of Pharmacology. XXVII. Classification of Cannabinoid Receptors

2002 • 2,707 citations

Expression of Central and Peripheral Cannabinoid Receptors in Human Immune Tissues and Leukocyte Subpopulations

1995 • 1,689 citations

Pharmacology of cannabinoid CB1 and CB2 receptors

1997 • 1,448 citations

A quick and simple method for the quantitation of lactate dehydrogenase release in measurements of cellular cytotoxicity and tumor necrosis factor (TNF) activity

1988 • 1,288 citations

Molecular targets for cannabidiol and its synthetic analogues: effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide

2001 • 1,212 citations

Cognitive Functioning of Long-term Heavy Cannabis Users Seeking Treatment

2002 • 785 citations

Secretion of Neurotoxins by Mononuclear Phagocytes Infected with HIV-1

1990 • 628 citations

Mast cells express a peripheral cannabinoid receptor with differential sensitivity to anandamide and palmitoylethanolamide.

1995 • 625 citations

Differences in the state of differentiation of THP-1 cells induced by phorbol ester and 1,25-dihydroxyvitamin D3

1996 • 562 citations

Evaluation of binding in a transfected cell line expressing a peripheral cannabinoid receptor (CB2): identification of cannabinoid receptor subtype selective ligands.

1996 • 555 citations

Immunomodulation by cannabinoids is absent in mice deficient for the cannabinoid CB2 receptor

2000 • 534 citations

Cannabinoids control spasticity and tremor in a multiple sclerosis model

2000 • 526 citations

Pharmacology of Cannabinoid Receptors

1995 • 485 citations

The residual cognitive effects of heavy marijuana use in college students

1996 • 480 citations

The endocannabinoid system as a target for therapeutic drugs

2000 • 427 citations

Levels, Metabolism, and Pharmacological Activity of Anandamide in CB₁ Cannabinoid Receptor Knockout Mice

2000 • 399 citations

CANNABINOID RECEPTORS AND THEIR ENDOGENOUS AGONISTS

1998 • 396 citations

Oxygenation of the Endocannabinoid, 2-Arachidonylglycerol, to Glyceryl Prostaglandins by Cyclooxygenase-2

2000 • 386 citations

Cannabinoid pharmacology

1987 • 368 citations

Fibrillar β-Amyloid Induces Microglial Phagocytosis, Expression of Inducible Nitric Oxide Synthase, and Loss of a Select Population of Neurons in the Rat CNSIn Vivo

1998 • 353 citations

Identification of Microglial Signal Transduction Pathways Mediating a Neurotoxic Response to Amyloidogenic Fragments of β-Amyloid and Prion Proteins

1999 • 353 citations

The Activity of Anandamide at Vanilloid VR1 Receptors Requires Facilitated Transport across the Cell Membrane and Is Limited by Intracellular Metabolism

2001 • 352 citations

The Residual Cognitive Effects of Heavy Marijuana Use in College Students

1996 • 343 citations

Differential expression of the CB2 cannabinoid receptor by rodent macrophages and macrophage-like cells in relation to cell activation

2002 • 328 citations

Agonist Selective Regulation of G Proteins by Cannabinoid CB₁and CB₂Receptors

1999 • 289 citations

Human monocytes/macrophages: NO or no NO?

1994 • 282 citations

Δ⁹‐Tetrahydrocannabinol induces apoptosis in C6 glioma cells

1998 • 280 citations

Cannabinoid receptors and the regulation of immune response

2000 • 280 citations

Therapeutic aspects of cannabis and cannabinoids

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Biochemistry and pharmacology of the endocannabinoids arachidonylethanolamide and 2-arachidonylglycerol

2000 • 237 citations

Hippocampal neurotoxicity of Delta9-tetrahydrocannabinol.

1998 • 237 citations

Cannabinoids inhibit LPS-inducible cytokine mRNA expression in rat microglial cells

2000 • 234 citations

The endocannabinoid nervous system

2001 • 233 citations

Cannabinoid receptors and immunity

1998 • 232 citations

Control of the cell survival/death decision by cannabinoids

2000 • 226 citations

The central cannabinoid receptor (CB1) mediates inhibition of nitric oxide production by rat microglial cells.

1999 • 219 citations

Hippocampal Neurotoxicity of Δ⁹-Tetrahydrocannabinol

1998 • 217 citations

Effects of cannabinoids on LPS‐stimulated inflammatory mediator release from macrophages: Involvement of eicosanoids

2001 • 213 citations

Amyloid β and Amylin Fibrils Induce Increases in Proinflammatory Cytokine and Chemokine Production by THP‐1 Cells and Murine Microglia

2000 • 205 citations

Localization of cannabinoid CB1 receptor mRNA in neuronal subpopulations of rat striatum: A double-label in situ hybridization study

2000 • 202 citations

Cloning and pharmacological characterization of the rat CB(2) cannabinoid receptor.

2000 • 199 citations

Cannabinoid Receptors Are Coupled to Nitric Oxide Release in Invertebrate Immunocytes, Microglia, and Human Monocytes

1996 • 187 citations

β-Amyloid protein-dependent nitric oxide production from microglial cells and neurotoxicity

1996 • 168 citations

Influence of fatty acid ethanolamides and Δ9-tetrahydrocannabinol on cytokine and arachidonate release by mononuclear cells

1997 • 160 citations

Gene expression profiling of amyloid beta peptide-stimulated human post-mortem brain microglia

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Cannabidiol-induced intracellular Ca2+ elevations in hippocampal cells

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Drugs and immunity: cannabinoids and their role in decreased resistance to infectious disease

1998 • 150 citations

Evaluation of the cannabinoid CB2 receptor-selective antagonist, SR144528: further evidence for cannabinoid CB2 receptor absence in the rat central nervous system

1999 • 146 citations

Neurotoxicology of cannabis and THC: A review of chronic exposure studies in animals

1991 • 111 citations

Cannabinoid inhibition of the processing of intact lysozyme by macrophages: evidence for CB2 receptor participation.

1999 • 110 citations

β-Amyloid induces increased release of interleukin-1β from lipopolysaccharide-activated human monocytes

1996 • 109 citations

Cyclooxygenase and 5-lipoxygenase inhibitors protect against mononuclear phagocyte neurotoxicity

2002 • 98 citations

Microglial Contribution to Oxidative Stress in Alzheimer's Disease

2000 • 96 citations

New class of potent ligands for the human peripheral cannabinoid receptor

1996 • 95 citations

Establishment of human adult astrocyte cultures derived from postmortem multiple sclerosis and control brain and spinal cord regions: immunophenotypical and functional characterization

1997 • 94 citations

Selective Killing of Cholinergic Neurons by Microglial Activation in Basal Forebrain Mixed Neuronal/Glial Cultures

1995 • 88 citations

Delta 9-tetrahydrocannabinol inhibition of tumor necrosis factor-alpha: suppression of post-translational events.

1993 • 79 citations

Isolation and characterization of adult microglial cells and oligodendrocytes derived from postmortem human brain tissue

2000 • 76 citations

The role of Cannabinoids in neurodegenerative diseases

2001 • 75 citations

Toxicity of human THP-1 monocytic cells towards neuron-like cells is reduced by non-steroidal anti-inflammatory drugs (NSAIDs)

1999 • 75 citations

The Search for Selective Ligands for the CB2 Receptor

2000 • 73 citations

Interaction of various intracellular signaling mechanisms involved in mononuclear phagocyte toxicity toward neuronal cells

2000 • 68 citations

Protection against septic shock and suppression of tumor necrosis factor alpha and nitric oxide production by dexanabinol (HU-211), a nonpsychotropic cannabinoid.

1997 • 67 citations

Inhibition by delta-9-tetrahydrocannabinol of tumor necrosis factor alpha production by mouse and human macrophages

1992 • 63 citations

Δ9-tetrahydrocannabinol (THC) modulates IL-1 bioactivity in human monocyte/macrophage cell lines

1994 • 44 citations

?-9-Tetrahydrocannabinol: Effect on macromolecular synthesis in human and other mammalian cells

1976 • 37 citations

R-(−)-Deprenyl Inhibits Monocytic THP-1 Cell Neurotoxicity Independently of Monoamine Oxidase Inhibition

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Influence of phenylmethylsulfonyl fluoride on anandamide brain levels and pharmacological effects

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Expression of Cannabinoid Receptor mRNA in Murine and Human Leukocytes

1995 • 23 citations

High-Level Expression of the Human CB2 Cannabinoid Receptor Using a Baculovirus System

1998 • 23 citations

Effects of Cannabinoids on the Immune System and Central Nervous System

1999 • 21 citations

Do SH-SY5Y Human Neuroblastoma Cells Express Cannabinoid Receptors ?

1995 • 6 citations

Tau protein after delta-9-tetrahydrocannabinol in a human neuroblastoma cell line

1996 • 3 citations