Protection against septic shock and suppression of tumor necrosis factor alpha and nitric oxide production by dexanabinol (HU-211), a nonpsychotropic cannabinoid.

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

Shock and Tissue Injury Induced by Recombinant Human Cachectin

1986 • 2,587 citations

Macrophage Cytotoxicity: Role for L-Arginine Deiminase and Imino Nitrogen Oxidation to Nitrite

1987 • 1,533 citations

Thalidomide exerts its inhibitory action on tumor necrosis factor alpha by enhancing mRNA degradation.

1993 • 1,058 citations

TUMOR NECROSIS FACTOR: A Pleiotropic Cytokine and Therapuetic Target

1994 • 1,047 citations

Cytokines and the nervous system II: actions and mechanisms of action

1995 • 928 citations

TUMOR NECROSIS, CACHEXIA, SHOCK, AND INFLAMMATION: A COMMON MEDIATOR

1988 • 814 citations

Production of tumor necrosis factor-alpha by microglia and astrocytes in culture

1989 • 626 citations

Inflammatory cytokines within the central nervous system: sources, function, and mechanism of action

1992 • 614 citations

Cytokine-to-brain communication: A review & analysis of alternative mechanisms

1995 • 579 citations

Detection of interleukin-1 and interleukin-6 in adult rat brain, following mechanical injury, by in vivo microdialysis: evidence of a role for microglia in cytokine production

1991 • 579 citations

Lethal toxicity of lipopolysaccharide and tumor necrosis factor in normal and D-galactosamine-treated mice.

1987 • 560 citations

Prevention of Lipopolysaccharide-Induced Lethal Toxicity by Tyrosine Kinase Inhibitors

1994 • 339 citations

Cytokine production in the brain following closed head injury: dexanabinol (HU-211) is a novel TNF-α inhibitor and an effective neuroprotectant

1997 • 332 citations

Tumor Necrosis Factor: The molecules and Their Emerging Role in Medicine

1992 • 330 citations

Pentoxifylline suppression of tumor necrosis factor gene transcription.

1991 • 316 citations

Acute in vivo effects of human recombinant tumor necrosis factor.

1987 • 256 citations

Long-term effect of HU-211, a novel non-competitive NMDA antagonist, on motor and memory functions after closed head injury in the rat

1995 • 192 citations

Nonpsychotropic cannabinoid acts as a functional N-methyl-D-aspartate receptor blocker.

1989 • 182 citations

Bicyclic Imidazoles as a Novel Class of Cytokine Biosynthesis Inhibitors

1993 • 146 citations

Tumor necrosis factor mediates endotoxic effects in mice

1987 • 140 citations

A Nonpsychotropic Cannabinoid, HU-211, Has Cerebroprotective Effects After Closed Head Injury in the Rat

1993 • 132 citations

Pathogenesis and Potential Strategies for Prevention and Treatment of Septic Shock: An Update

1994 • 116 citations

Endotoxin-Induced Release of Interleukin-6 from Rat Medial Basal Hypothalami*

1990 • 107 citations

HU-211, a Novel Noncompetitive N -Methyl- <scp>d-</scp> Aspartate Antagonist, Improves Neurological Deficit and Reduces Infarct Volume After Reversible Focal Cerebral Ischemia in the Rat

1995 • 97 citations

Tumor necrosis factor (cachectin) in the biology of septic shock syndrome.

1991 • 94 citations

Beneficial effects of TCV-309, a novel potent and selective platelet activating factor antagonist in endotoxin and anaphylactic shock in rodents.

1992 • 79 citations

Inhibition of nitric oxide synthesis improves survival in a murine peritonitis model of sepsis that is not cured by antibiotics alone

1992 • 74 citations

45Ca accumulation in rat brain after closed head injury; attenuation by the novel neuroprotective agent HU-211

1995 • 69 citations

HU-211, a nonpsychotropic cannabinoid, rescues cortical neurones from excitatory amino acid toxicity in culture

1993 • 65 citations

Stimulation of tumor necrosis factor-α production by mycoplasmas and inhibition by dexamethasone in cultured astrocytes

1993 • 65 citations

Neuroprotective activity of HU-211, a novel NMDA antagonist, in global ischemia in gerbils

1994 • 56 citations

9-Tetrahydrocannabinol, Cytokines, and Immunity to Legionella pneumophila

1995 • 55 citations

Blockade of45Ca2+ influx through theN-methyl-d-aspartate receptor ion channel by the non-psychoactive cannabinoid HU-211

1993 • 54 citations

The non-psychotropic cannabinoid (+)-(3S,4S)-7-hydroxy-Δ6-tetrahydrocannabinol 1,1-dimethylheptyl (HU-211) attenuates receptor-mediated neurotoxicity in primary cultures of rat forebrain

1993 • 52 citations

Differential Inhibition of RAW264.7 Macrophage Tumoricidal Activity by 9Tetrahydrocannabinol

1995 • 47 citations

Use of Nitric Oxide Synthase Inhibitors as a Novel Treatment for Septic Shock

1995 • 43 citations

Further Studies on the Stimulatory Action of Nicotine on Adrenocortical Function in the Rat

1989 • 39 citations

Post-ischemic administration of HU-211, a novel non-competitive NMDA antagonist, protects against blood-brain barrier disruption in photochemical cortical infarction in rats: a quantitative study

1995 • 37 citations

A Novel Nonpsychotropic Cannabinoid, HU-211, in the Treatment of Experimental Pneumococcal Meningitis

1996 • 36 citations

Mycoplasma stimulates the production of oxidative radicals by murine peritoneal macrophages

1995 • 33 citations

Cannabinoid interactions with glucocorticoid receptors in rat hippocampus

1990 • 32 citations

Pyridinyl imidazoles inhibit the inflammatory phase of delayed type hypersensitivity reactions without affecting T-dependent immune responses

1994 • 24 citations

Endogenous and Synthetic Cannabinoids: Recent Advances

1996 • 14 citations

Centrally acting endogenous hypotensive substances in rats subjected to endotoxic shock

1992 • 8 citations