The Management of Diabetes Mellitus in Older Individuals

Development and validation of a geriatric depression screening scale: A preliminary report

1982 • 14,099 citations

Cognitive Stimulation in Patients with Dementia: Randomized Controlled Trial

2013 • 3,343 citations

Advanced Glycosylation End Products in Tissue and the Biochemical Basis of Diabetic Complications

1988 • 2,527 citations

High-intensity strength training in nonagenarians. Effects on skeletal muscle

1990 • 1,799 citations

Impact of obesity on metabolism in men and women. Importance of regional adipose tissue distribution.

1983 • 1,455 citations

Diabetes Mellitus and Its Degenerative Complications: A Prospective Study of 4,400 Patients Observed Between 1947 and 1973

1978 • 1,311 citations

Prevalence of Diabetes and Impaired Glucose Tolerance and Plasma Glucose Levels in U.S. Population Aged 20–74 Yr

1987 • 1,072 citations

Reduced Thirst after Water Deprivation in Healthy Elderly Men

1984 • 756 citations

Glucose Toxicity

1990 • 742 citations

Increased damage after ischemic stroke in patients with hyperglycemia with or without established diabetes mellitus

1983 • 633 citations

Oral Hypoglycemic Agents

1989 • 483 citations

The receptor for antidiabetic sulfonylureas controls the activity of the ATP-modulated K+ channel in insulin-secreting cells.

1987 • 452 citations

Comparison of a High-Carbohydrate Diet with a High-Monounsaturated-Fat Diet in Patients with Non-Insulin-Dependent Diabetes Mellitus

1988 • 403 citations

Anorexia in the elderly

1988 • 359 citations

Relationship Between Hyperglycemia and Cognitive Function in Older NIDDM Patients

1990 • 340 citations

Pharmacokinetics in the Elderly

1976 • 338 citations

Lower prevalence of breast cancer and cancers of the reproductive system among former college athletes compared to non-athletes

1985 • 326 citations

Decreased cognitive function in aging non-insulin-dependent diabetic patients

1984 • 297 citations

SERUM-ZINC AND HEALING OF VENOUS LEG ULCERS

1972 • 294 citations

Abnormal zinc metabolism in type II diabetes mellitus

1984 • 279 citations

Drug-Induced Hypoglycemia: A Review of 1418 Cases

1989 • 266 citations

The effect of ageing on the hepatic clearance of propranolol.

1979 • 241 citations

Modulation of memory processing by neuropeptide Y

1987 • 222 citations

Micronutrient status in diabetes mellitus

1987 • 207 citations

Mechanism of pain in diabetic peripheral neuropathy

1984 • 206 citations

The Acute and Chronic Effects of Sulfonylurea Therapy in Type II Diabetic Subjects

1984 • 205 citations

Reduced Serum Albumin Concentration in the Elderly: A Report from the Boston Collaborative Drug Surveillance Program

1979 • 203 citations

Nutritional status of the elderly

1986 • 203 citations

Symptomatic Hypoglycemia in NIDDM Patients Treated With Oral Hypoglycemic Agents

1989 • 196 citations

The Economic Costs of Non—Insulin-Dependent Diabetes Mellitus

1989 • 191 citations

Exercise in a behavioural weight control programme for obese patients with Type 2 (non-insulin-dependent) diabetes

1988 • 190 citations

Characteristics of Learning and Memory in Streptozocin-Induced Diabetic Mice

1990 • 174 citations

Metformin: a review of its pharmacological properties and therapeutic use.

1979 • 172 citations

Cortical function in elderly non-insulin dependent diabetic patients. Behavioral and electrophysiologic studies.

1988 • 164 citations

Pharmacogenetics of Tolbutamide Metabolism in Humans

1978 • 160 citations

Clinical Pharmacology of Sulphonylurea Hypoglycaemic Agents

1981 • 159 citations

TABLES OF AVERAGE WEIGHT AND HEIGHT OF AMERICANS AGED 65 TO 94 YEARS

1960 • 153 citations

Modulation of memory processing by neuropeptide Y varies with brain injection site

1989 • 150 citations

Role of zinc supplementation in type II diabetes mellitus

1986 • 128 citations

INCREASED INSULIN SENSITIVITY AND CELLULAR INSULIN BINDING IN OBESE DIABETICS FOLLOWING TREATMENT WITH GLIBENCLAMIDE

1979 • 127 citations

Characterization of the sulfonylurea receptor on beta cell membranes.

1988 • 120 citations

The effects of aging on opioid modulation of feeding in rats

1983 • 112 citations

The Effectiveness of Diabetes Education Programs for Older Patients and Their Spouses

1989 • 109 citations

The Effect of Exercise on Natural Killer Cell Activity in Young and Old Subjects

1989 • 109 citations

Sulphonylurea Antidiabetic Drugs

1989 • 108 citations

Pancreatic action of the sulfonylureas.

1977 • 107 citations

Brain Damage in Diabetes Mellitus

1973 • 107 citations

The Scientific Basis of Exercise Prescribing for the Very Old

1990 • 104 citations

Clinical Pharmacokinetics of Sulphonylurea Hypoglycaemic Drugs

1981 • 102 citations

Diabetes mellitus in elderly patients

1987 • 101 citations

The Mental Efficiency of the Elderly Person with Type II Diabetes Mellitus

1990 • 101 citations

Diabetes Mellitus in Elderly Nursing Home Patients A Survey of Clinical Characteristics and Management

1988 • 99 citations

Metformin reduces insulin requirement in Type 1 (insulin-dependent) diabetes

1983 • 97 citations

Dietary management of nursing home residents with non-insulin-dependent diabetes mellitus

1990 • 94 citations

The Relationship Between the Pharmacokinetics and Pharmacodynamic Effects of Oral Hypoglycaemic Drugs

1987 • 92 citations

Metformin Revisited: Its Actions and Indications for Use

1988 • 88 citations

Effect of Habitual Physical Activity on Regulation of Insulin‐stimulated Glucose Disposal in Older Males

1985 • 88 citations

Metformin and the sulphonylureas: the comparative risk.

1985 • 85 citations

HYPERGLYCAEMIA AND ABSORPTION OF SULPHONYLUREA DRUGS

1989 • 85 citations

Human Growth Hormone and Cortisol Response to Insulin Stimulation in Aging

1975 • 81 citations

Drug Interactions with Oral Sulphonylurea Hypoglycaemic Drugs

1977 • 81 citations

Role of metformin in treatment of diabetes mellitus

1987 • 79 citations

Comparative effects of phenformin, metformin and glibenclamide on metabolic rhythms in maturity-onset diabetics

1977 • 75 citations

Effect of gastrointestinal peptides on ingestion in old and young mice

1988 • 75 citations

Evidence for synergism between chromium and nicotinic acid in the control of glucose tolerance in elderly humans

1987 • 73 citations

Comparison of Tolbutamide and Metformin in Elderly Diabetic Patients

1990 • 73 citations

Diet and the Diabetic Patient

1983 • 73 citations

Geriatric Grand Rounds: Nutrition and the Elderly: University of California, Los Angeles

1986 • 70 citations

THE EFFECT OF AGE ON THE HYDROXYLATION OF AMYLOBARBITONE SODIUM IN MAN

1974 • 70 citations

11 Treatment—metformin

1988 • 69 citations

Aging and Postural Hypotension

1989 • 66 citations

The binding of sulphonylureas to serum albumin

1974 • 65 citations

Depression

1989 • 61 citations

Chlorpropamide-induced Hyponatremia: Incidence and Risk Factors

1983 • 60 citations

Prolonged sulfonylurea administration decreases insulin resistance and increases insulin secretion in non-insulin-dependent diabetes mellitus: evidence for improved insulin action at a postreceptor site in hepatic as well as extrahepatic tissues.

1984 • 60 citations

The Influence of Aging on Hemoglobin A1c(HbA1c)

1982 • 60 citations

Glibenclamide is exceptional among hypoglycaemic sulphonylureas in accumulating progressively in β-cell-rich pancreatic islets

1984 • 58 citations

The effect of oral glucose, protein, fat and water loading on blood pressure and the gastrointestinal peptides VIP and somatostatin in hypertensive elderly subjects

1990 • 57 citations

Effects of Age on Complications in Adult Onset Diabetes

1989 • 56 citations

Pharmacokinetic changes in aging

1986 • 56 citations

Growth Hormone Response to Insulin Hypoglycemia in the Elderly

1973 • 55 citations

Farewell to Phenformin for Treating Diabetes Mellitus

1975 • 55 citations

Sulfonylureas Do Not Affect Insulin Binding or Glycemic Control in Insulin-dependent Diabetics

1982 • 54 citations

Glipizide

1979 • 53 citations

Incidence of severe sideeffects during therapy with sulfonylureas and biguanides.

1985 • 52 citations

Utility of serum fructosamine as a measure of glycemia in young and old diabetic and non-diabetic subjects

1988 • 51 citations

[The relatively frequent incidence of severe sulfonylurea-induced hypoglycemia in the last 25 years in Switzerland. Results of 2 surveys in Switzerland in 1969 and 1984].

1986 • 51 citations

Effects of Self‐Monitoring of Blood Glucose on Quality of Life in Elderly Diabetic Patients

1990 • 51 citations

Addition of Sulfonylurea to Insulin Treatment in Poorly Controlled Type II Diabetes

1987 • 50 citations

Metabolism and Kinetics of the Hypoglycemic Agent Glipizide in Man—Comparison with Glibenclamide

1973 • 50 citations

The pharmacokinetics of chlormethiazole following intravenous administration in the aged

1976 • 50 citations

Psychometric evaluation of performance in diabetes mellitus.

1980 • 50 citations

Neuropsychological Function in Diabetic Patients with Neuropathy

1984 • 49 citations

Mortality in a cohort of diabetic patients

1989 • 49 citations

Glyburide and glipizide, second-generation oral sulfonylurea hypoglycemic agents.

1984 • 49 citations

Accuracy of insulin injection in elderly patients.

1983 • 48 citations

The Effect of Chronic Oral Antidiabetic Therapy on Insulin and Glucagon Responses to a Meal

1977 • 47 citations

Behaviour of glibenclamide on repeated administration to diabetic patients

1977 • 45 citations

Metabolism, Blood Levels and Rate of Excretion of Acetohexamide in Human Subjects

1967 • 43 citations

Pharmacokinetics and pharmacodynamics as well as metabolism following orally and intravenously administered C14-glipizide, a new antidiabetic

1973 • 42 citations

Serum Concentration and Urinary Excretion of Oral Sulfonylurea Compounds: Relation to Diabetic Control

1965 • 40 citations

Metabolism of antidiabetic sulfonylureas in man

1965 • 38 citations

Effect of metformin on hepatocyte insulin receptor binding in normal, streptozotocin diabetic and genetically obese diabetic (ob/ob) mice

1983 • 37 citations

Clinical pharmacology of sulfonylureas

1987 • 31 citations

GLIBENCLAMIDE INDUCED PROLONGED HYPOGLYCAEMIA

1986 • 30 citations

Tolbutamide does not alter insulin requirement in Type 1 (insulin-dependent) diabetes

1984 • 30 citations

The Physiological Significance of the Glucose Intolerance of Aging

1984 • 29 citations

Improved diabetic control in insulin-dependent diabetics treated with insulin and glibenclamide

1984 • 28 citations

Interactions of Sulfonylureas with Plasma Proteins

1974 • 27 citations

Prolonged Hypoglycemia Following Acetohexamide Administration: Report of Two Cases with Impaired Renal Function

1966 • 25 citations

Unique Aspects of Diabetes Mellitus in the Elderly

1990 • 25 citations

[Studies on the bioavailability of glibenclamide].

1972 • 25 citations

Combined Insulin-Sulfonylurea Therapy in Treatment of NIDDM

1990 • 21 citations

Drug Utilization and Morbidity Statistics for the Evaluation of Drug Safety in Sweden

1984 • 20 citations

Clinical experience with orinase.

1956 • 19 citations

Urinary Glucose Testing Inaccuracies Among Diabetic Patients

1984 • 19 citations

Des 4-trans-hydroxy-glibenclamide show hypoglycemic activity?

1979 • 17 citations

Why do elderly diabetics burden the health care system more than non-diabetics?

1989 • 17 citations

UCLA Geriatric Grand Rounds: Diabetes in the Elderly

1987 • 16 citations

High K+ Rapidly Stimulates Ca2+-Dependent Phosphorylation of Three Proteins Concomitant With Insulin Secretion From HIT Cells

1987 • 15 citations

Why do elderly diabetics burden the health care system more than non-diabetics?

1989 • 15 citations

Clinical Evaluation of Serum Fructosamine in Monitoring Elderly Outpatient Diabetics

1989 • 13 citations

Evidence that metformin addition to insulin induces an amelioration of glycaemic profile in type I (insulin-dependent) diabetes mellitus

1984 • 13 citations

Oral Sulfonylureas for the Treatment of Type II Diabetes: An Update

1986 • 10 citations

An Evaluation of the Therapeutic Effects and Dosage Equivalence of Glyburide and Glipizide

1990 • 9 citations

Principles of Geriatric Care

1990 • 9 citations

[Current pathophysiological and clinical aspects of the mode of action of blood glucose lowering sulfonamides].

1969 • 8 citations

Release of Glucagon-Like Immunoreactive Material (GLI) from the Isolated Perfused Jejunum of Normal and Diabetic Rats

1985 • 7 citations

Diet and the diabetic patient

1984 • 6 citations

[Fructosamine values in hyperthyroidism, hypothyroidism and gammopathy].

1990 • 4 citations

[24-hour blood pressure determination in Shy-Drager syndrome. A case report].

1990 • 2 citations