11 Treatment—metformin

Diabetes and atherosclerosis: An epidemiologic view

1987 • 936 citations

Mortality and survival in Type 2 (non-insulin-dependent) diabetes mellitus

1987 • 560 citations

Metformin kinetics in healthy subjects and in patients with diabetes mellitus.

1981 • 477 citations

Pharmacokinetics of metformin after intravenous and oral administration to man

1979 • 339 citations

Reduction of metformin renal tubular secretion by cimetidine in man.

1987 • 281 citations

New concepts in the pathogenesis and treatment of noninsulin-dependent diabetes mellitus

1983 • 266 citations

Diabetes and atherosclerosis ? The role of insulin

1979 • 222 citations

Disposition of metformin (N,N‐dimethylbiguanide) in man

1978 • 216 citations

Mechanism of Metformin Action in Non-Insulin-Dependent Diabetes

1987 • 184 citations

Metformin: a review of its pharmacological properties and therapeutic use.

1979 • 172 citations

Metformin Decreases the High Plasminogen Activator Inhibition Capacity, Plasma Insulin and Triglyceride Levels in Non-Diabetic Obese Subjects

1987 • 166 citations

Metformin in the digestive tract

1988 • 118 citations

Specific Inhibition of Gluconeogenesis by Biguanides

1967 • 109 citations

Inhibition of hepatic gluconeogenesis by metformin

1988 • 108 citations

COMPARISON OF CHLORPROPAMIDE AND METFORMIN TREATMENT ON WEIGHT AND BLOOD-GLUCOSE RESPONSE OF UNCONTROLLED OBESE DIABETICS

1968 • 107 citations

Effect of Metformin on Insulin-Stimulated Glucose Turnover and Insulin Binding to Receptors in Type II Diabetes

1987 • 105 citations

Analysis of the inhibitory effect of biguanides on glucose absorption: Inhibition of active sugar transport

1971 • 101 citations

Effect of metformin on peripheral insulin sensitivity in non insulin dependent diabetes mellitus.

1986 • 99 citations

Biguanides. A review of history, pharmacodynamics and therapy.

1983 • 99 citations

Metformin reduces insulin requirement in Type 1 (insulin-dependent) diabetes

1983 • 97 citations

The difficult choice of treatment for poorly controlled maturity onset diabetes: tablets or insulin?

1984 • 95 citations

Epidemiology of adverse drug reactions to phenformin and metformin.

1978 • 93 citations

Comparison of metformin and chlorpropamide in non-obese, maturity-onset diabetics uncontrolled by diet.

1977 • 92 citations

Effect of metformin on glucose metabolism in mouse soleus muscle.

1986 • 90 citations

Metformin Revisited: Its Actions and Indications for Use

1988 • 88 citations

Mechanism of Action of Metformin: Insulin Receptor and Postreceptor Effects in Vitro and in Vivo*

1986 • 86 citations

Metformin and the sulphonylureas: the comparative risk.

1985 • 85 citations

Biguanides

1978 • 85 citations

Metformin improved insulin resistance in type I, insulin-dependent, diabetic patients

1985 • 82 citations

LACTIC ACIDOSIS

1977 • 78 citations

Comparative effects of phenformin, metformin and glibenclamide on metabolic rhythms in maturity-onset diabetics

1977 • 75 citations

Sulphonylurea Failure in Type 2 Diabetes: Treatment with a Basal Insulin Supplement

1987 • 73 citations

U.K. Prospective Diabetes Study: II. Reduction in HbA1c with Basal Insulin Supplement, Sulfonylurea, or Biguanide Therapy in Maturity-onset Diabetes

1985 • 73 citations

Megaloblastic anaemia due to vitamin B12 malabsorption associated with long-term metformin treatment.

1980 • 72 citations

Mechanism of metformin action in non-insulin-dependent diabetes

1987 • 68 citations

Malabsorption of Vitamin B12 in Diabetic Patients Treated with Phenformin: A Comparison with Metformin

1973 • 67 citations

Metformin Improves Peripheral Vascular Flow in Nonhyperlipidemic Patients with Arterial Disease

1984 • 63 citations

The status of metformin in Canada.

1983 • 60 citations

Biguanide Treatment Increases the Number of Insulin-Receptor Sites on Human Erythrocytes

1981 • 59 citations

Leg Blood Flow and Muscle Metabolism in Occlusive Arterial Disease of the Leg before and after Reconstructive Surgery

1975 • 57 citations

Autoregulation by glucose of hepatic glucose balance: Permissive effect of insulin

1981 • 56 citations

Insulin Receptor Binding to Monocytes, Insulin Secretion, and Glucose Tolerance Following Metformin Treatment: Results of a Double-Blind Cross-Over Study in Type II Diabetics

1983 • 54 citations

KINETIC STUDY OF NORMAL AND SUSTAINED RELEASE DOSAGE FORMS OF METFORMIN IN NORMAL SUBJECTS

1980 • 53 citations

FIBRINOLYTIC EFFECT OF METFORMIN IN CORONARY-ARTERY DISEASE

1965 • 52 citations

Inhibition of intestinal absorption and improvement of oral glucose tolerance by biguanides in the normal and in the streptozotocin-diabetic rat

1971 • 51 citations

Role of insulin, glucose, and cyclic GMP in the regulation of glucokinase in cultured hepatocytes.

1981 • 50 citations

Effects of metformin on glucose uptake by isolated diaphragm from normal and diabetic rats

1972 • 48 citations

Treatment of hypertriglyceridemia with metformin

1977 • 48 citations

Effect of metformin on insulin receptor binding and glycaemic control in type II diabetes.

1983 • 46 citations

The Effect of Metformin on Glycaemic Control, Intermediary Metabolism and Blood Pressure in Non‐insulin‐dependent Diabetes Mellitus

1987 • 43 citations

[5] Glucokinase of rat liver

1975 • 43 citations

Metformin and glibenclamide: comparative risks.

1984 • 42 citations

Metformin Normalizes Insulin Binding to Monocytes from Obese Nondiabetic Subjects and Obese Type II Diabetic Patients

1983 • 41 citations

Circadian Variation of Glucose, Insulin, and Free Fatty Acids During Long-term Use of Oral Hypoglycaemic Agents in Diabetes Mellitus

1968 • 41 citations

Effects of metformin on insulin receptor tyrosine kinase activity in rat adipocytes

1986 • 39 citations

Effect of metformin on hepatocyte insulin receptor binding in normal, streptozotocin diabetic and genetically obese diabetic (ob/ob) mice

1983 • 37 citations

Effect of optimal glycaemic control with continuous subcutaneous insulin infusion on energy expenditure in type I diabetes mellitus.

1986 • 35 citations

Metformin reduces platelet hypersensitivity in hypercholesterolemic rabbits

1982 • 33 citations

Leucocytoclastic vasculitis and pneumonitis induced by metformin.

1986 • 32 citations

Guanidines and biguanides

1980 • 31 citations

METFORMIN ADMINISTRATION IN HYPERLIPIDEMIC STATES

1971 • 30 citations

Postreceptor effect of metformin on insulin action in mice

1985 • 30 citations

Treatment of streptozotocin-diabetic rats with metformin restores the ability of insulin to inhibit adenylate cyclase activity and demonstrates that insulin does not exert this action through the inhibitory guanine nucleotide regulatory protein Gi

1988 • 30 citations

Inhibitory effects of metformin on insulin and glucagon action in rat hepatocytes involve post-receptor alterations.

1987 • 28 citations

DIMETHYLDIGUANIDE IN THE TREATMENT OF DIABETIC CHILDREN

1961 • 28 citations

Metformin action on lipid metabolism in lesions of experimental aortic atherosclerosis of rabbits

1983 • 27 citations

Anorectic effect of metformin in lean and genetically obese hyperglycaemic (ob/ob) mice.

1986 • 27 citations

The oral hypoglycemic agents.

1971 • 27 citations

Effect of metformin on insulin binding to receptors in cultured human lymphocytes and cancer cells

1982 • 26 citations

Hormone and metabolite profiles in alcoholic liver disease

1983 • 26 citations

Direct effects of biguanides on glucose utilization in vitro

1987 • 25 citations

Value of glucose control in preventing complications of diabetes

1985 • 25 citations

Insulin receptor binding to monocytes, insulin secretion, and glucose tolerance following metformin treatment. Results of a double-blind cross-over study in type II diabetics

1983 • 24 citations

THE EFFECT OF METFORMIN ON WEIGHT LOSS IN OBESITY

1965 • 24 citations

Effect of metformin on lipid metabolism in the rabbit aortic wall

1978 • 23 citations

Metabolic Effects of Combined Sulphonylurea and Metformin Therapy in Maturity-Onset Diabetics

1979 • 22 citations

Lactic Acidotic Coma with Multiple Medication Including Metformin in a Patient with Normal Renal Function

1984 • 22 citations

Insulin Resistance in Non-Insulin Dependent (Type II) and Insulin Dependent (Type I) Diabetes Mellitus

1985 • 22 citations

Inhibition of Carbohydrate-Induced Hypertriglyceridemia by Metformin

1984 • 21 citations

U.K. prospective diabetes study. II. Reduction in HbA1c with basal insulin supplement, sulfonylurea, or biguanide therapy in maturity-onset diabetes. A multicenter study

1985 • 21 citations

DOUBLE‐BLIND TRIAL OF METFORMIN IN THE THERAPY OF NONKETOTIC DIABETICS

1979 • 19 citations

Effects of metformin treatment on erythrocyte insulin binding in normal weight subjects, in obese non diabetic subjects, in type 1 and type 2 diabetic patients.

1986 • 19 citations

Serum lipids and Lipoproteins in type 2 diabetes

1983 • 18 citations

Plasma fibrinogen in diabetes mellitus.

1979 • 18 citations

Results with a Catheterless Insulin Delivery Device Implanted in a Pancreatectomized Dog

1983 • 17 citations

Metformin and lactic acidosis--a reminder.

1987 • 15 citations

Mode of action of hypoglycemic agents—IV

1973 • 15 citations

Evidence that metformin addition to insulin induces an amelioration of glycaemic profile in type I (insulin-dependent) diabetes mellitus

1984 • 13 citations

Combined sulphonylurea-biguanide therapy for non-insulin dependent diabetics. Metabolic effects of glibenclamide and metformin or phenformin in newly diagnosed obese patients

1982 • 12 citations

The hypoglycaemic action of metformin

1971 • 12 citations

Glucose Tolerance in Aging Obese (ob/ob) and Lean Mice

1983 • 9 citations

Metformin enhances insulin binding to "in vitro" down regulated human fat cells.

1987 • 8 citations

The Lung, Whole‐Body Metabolism and Disease

1980 • 4 citations

Chronic effects of glibenclamide, chlorpropamide and metformin on plasma glucose and insulin in non-diabetic rats

1981 • 4 citations

Treatment of the obese diabetic patient.

1967 • 4 citations

Lack of Effect of Glibenclamide, Chlorpropamide and Metformin on Plasma Cholesterol and HDL-Cholesterol in Non-Diabetic Rats

1980 • 2 citations

Deleted Work

1955 • 0 citations