Specific binding of RNA polymerase II to the human immunodeficiency virus trans-activating region RNA is regulated by cellular cofactors and Tat.

Anti-termination of transcription within the long terminal repeat of HIV-1 by tat gene product

1987 • 902 citations

The location of cis-acting regulatory sequences in the human T cell lymphotropic virus type III (HTLV-III/LAV) long terminal repeat

1985 • 825 citations

RNA POLYMERASE II

1991 • 729 citations

Tat trans-activates the human immunodeficiency virus through a nascent RNA target

1989 • 644 citations

The trans-activator gene of HTLV-III is essential for virus replication

1986 • 635 citations

The trans-activator gene of the human T cell lymphotropic virus type III is required for replication

1986 • 615 citations

HIV-1 Tat protein increases transcriptional initiation and stabilizes elongation

1989 • 577 citations

HIV-1 tat trans-activation requires the loop sequence within tar

1988 • 551 citations

Relationship of CDK-activating kinase and RNA polymerase II CTD kinase TFIIH/TFIIK

1994 • 426 citations

A bulge structure in HIV-1 TAR RNA is required for Tat binding and Tat-mediated trans-activation.

1990 • 412 citations

Human general transcription factor IIH phosphorylates the C-terminal domain of RNA polymerase II

1992 • 407 citations

HIV-1 tat protein stimulates transcription by binding to a U-rich bulge in the stem of the TAR RNA structure.

1990 • 400 citations

The role of Tat in the human immunodeficiency virus life cycle indicates a primary effect on transcriptional elongation.

1991 • 360 citations

Cellular Transcription Factors Involved in the Regulation of HIV-1 Gene Expression

1992 • 341 citations

Analysis of arginine-rich peptides from the HIV Tat protein reveals unusual features of RNA-protein recognition.

1991 • 328 citations

RNA recognition by Tat-derived peptides: Interaction in the major groove?

1991 • 319 citations

HIV-1 Tat protein promotes formation of more-processive elongation complexes.

1991 • 295 citations

Messenger RNA synthesis in mammalian cells is catalyzed by the phosphorylated form of RNA polymerase II.

1987 • 288 citations

Human immunodeficiency virus type 1 LTR TATA and TAR region sequences required for transcriptional regulation.

1989 • 275 citations

Phosphorylation of RNA polymerase by the murine homologue of the cell-cycle control protein cdc2

1989 • 270 citations

Inhibition of in Vivo and in Vitro Transcription by Monoclonal Antibodies Prepared against Wheat Germ RNA Polymerase II That React with the Heptapeptide Repeat of Eukaryotic RNA Polymerase II

1989 • 228 citations

trans activation of human immunodeficiency virus type 1 is sequence specific for both the single-stranded bulge and loop of the trans-acting-responsive hairpin: a quantitative analysis

1989 • 224 citations

Specific interaction between the nonphosphorylated form of RNA polymerase II and the TATA-binding protein

1992 • 219 citations

HIV-1 Tat acts as a processivity factor in vitro in conjunction with cellular elongation factors.

1992 • 195 citations

Factors involved in specific transcription by mammalian RNA polymerase II. Transcription factor IIS stimulates elongation of RNA chains.

1987 • 160 citations

tat regulates binding of the human immunodeficiency virus trans-activating region RNA loop-binding protein TRP-185.

1991 • 139 citations

Two distinct nuclear transcription factors recognize loop and bulge residues of the HIV-1 TAR RNA hairpin.

1991 • 137 citations

The HIV-1 long terminal repeat contains an unusual element that induces the synthesis of short RNAs from various mRNA and snRNA promoters.

1990 • 123 citations

Footprinting analysis of mammalian RNA polymerase II along its transcript: an alternative view of transcription elongation.

1991 • 92 citations

Complexes of yeast RNA polymerase II and RNA are substrates for TFIIS-induced RNA cleavage

1994 • 73 citations

Differential growth kinetics are exhibited by human immunodeficiency virus type 1 TAR mutants

1994 • 48 citations

Transcriptional elongation by purified RNA polymerase II is blocked at the trans-activation-responsive region of human immunodeficiency virus type 1 in vitro

1991 • 30 citations