Leukocyte membrane adhesion proteins LFA-1, CR3 and p150,95: A review of functional and regulatory aspects

New Perspectives in Cell Adhesion: RGD and Integrins

1987 • 4,835 citations

Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.

1982 • 4,786 citations

Integrins: A family of cell surface receptors

1987 • 4,322 citations

Induction by IL 1 and interferon-gamma: tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1).

1986 • 2,490 citations

Purified intercellular adhesion molecule-1 (ICAM-1) is a ligand for lymphocyte function-associated antigen 1 (LFA-1)

1987 • 1,712 citations

Identification of an inducible endothelial-leukocyte adhesion molecule.

1987 • 1,639 citations

Overlapping patterns of activation of human endothelial cells by interleukin 1, tumor necrosis factor, and immune interferon.

1986 • 1,439 citations

A human intercellular adhesion molecule (ICAM-1) distinct from LFA-1.

1986 • 1,428 citations

An alternative pathway of T-cell activation: A functional role for the 50 kd T11 sheep erythrocyte receptor protein

1984 • 1,132 citations

Lymphocyte function-associated antigen-1 (LFA-1) interaction with intercellular adhesion molecule-1 (ICAM-1) is one of at least three mechanisms for lymphocyte adhesion to cultured endothelial cells.

1988 • 988 citations

Human memory T lymphocytes express increased levels of three cell adhesion molecules (LFA-3, CD2, and LFA-1) and three other molecules (UCHL1, CDw29, and Pgp-1) and have enhanced IFN-gamma production.

1988 • 917 citations

A human leukocyte differentiation antigen family with distinct alpha-subunits and a common beta-subunit: the lymphocyte function-associated antigen (LFA-1), the C3bi complement receptor (OKM1/Mac-1), and the p150,95 molecule.

1983 • 888 citations

Functional cloning of ICAM-2, a cell adhesion ligand for LFA-1 homologous to ICAM-1

1989 • 837 citations

Two distinct monokines, interleukin 1 and tumor necrosis factor, each independently induce biosynthesis and transient expression of the same antigen on the surface of cultured human vascular endothelial cells.

1986 • 748 citations

Identification of multiple cell adhesion receptors for collagen and fibronectin in human fibrosarcoma cells possessing unique alpha and common beta subunits.

1987 • 727 citations

A lymphocyte molecule implicated in lymph node homing is a member of the cartilage link protein family

1989 • 680 citations

Laminin receptor on platelets is the integrin VLA-6

1988 • 679 citations

The Severe and Moderate Phenotypes of Heritable Mac-1, LFA-1 Deficiency: Their Quantitative Definition and Relation to Leukocyte Dysfunction and Clinical Features

1985 • 644 citations

ICAM, an adhesion ligand of LFA-1, is homologous to the neural cell adhesion molecule NCAM

1988 • 631 citations

Recognition of an endothelial determinant for CD 18-dependent human neutrophil adherence and transendothelial migration.

1988 • 626 citations

An endothelial cell surface factor(s) induced in vitro by lipopolysaccharide, interleukin 1, and tumor necrosis factor-alpha increases neutrophil adherence by a CDw18-dependent mechanism.

1986 • 593 citations

The functional significance, distribution, and structure of LFA-1, LFA-2, and LFA-3: cell surface antigens associated with CTL-target interactions.

1983 • 583 citations

ICAM-1 a ligand for LFA-1-dependent adhesion of B, T and myeloid cells

1988 • 580 citations

Biosynthetic and functional properties of an Arg-Gly-Asp-directed receptor involved in human melanoma cell attachment to vitronectin, fibrinogen, and von Willebrand factor.

1987 • 574 citations

A human lymphocyte homing receptor, the Hermes antigen, is related to cartilage proteoglycan core and link proteins

1989 • 568 citations

Lymphocyte recognition of high endothelium: antibodies to distinct epitopes of an 85-95-kD glycoprotein antigen differentially inhibit lymphocyte binding to lymph node, mucosal, or synovial endothelial cells.

1987 • 554 citations

Cloning of the $beta; subunit of the leukocyte adhesion proteins: Homology to an extracellular matrix receptor defines a novel supergene family

1987 • 520 citations

The VLA protein family. Characterization of five distinct cell surface heterodimers each with a common 130,000 molecular weight beta subunit.

1987 • 512 citations

Antigen presentation: comments on its regulation and mechanism.

1984 • 498 citations

Identification of a murine Peyer's patch—specific lymphocyte homing receptor as an integrin molecule with an α chain homologous to human VLA-4α

1989 • 495 citations

Inherited deficiency of the Mac-1, LFA-1, p150,95 glycoprotein family and its molecular basis.

1984 • 495 citations

Receptors for C3b and C3bi promote phagocytosis but not the release of toxic oxygen from human phagocytes.

1983 • 495 citations

The requirement for lymphocyte function-associated antigen 1 in homotypic leukocyte adhesion stimulated by phorbol ester.

1986 • 487 citations

Complement receptor type three (CD11b/CD18) of human polymorphonuclear leukocytes recognizes fibrinogen.

1988 • 457 citations

Tumor-promoting phorbol esters stimulate C3b and C3b' receptor-mediated phagocytosis in cultured human monocytes.

1982 • 444 citations

Regulation of the fibronectin receptor affinity by divalent cations.

1988 • 441 citations

Two antigen-independent adhesion pathways used by human cytotoxic T-cell clones

1986 • 437 citations

Stimulated mobilization of monocyte Mac-1 and p150,95 adhesion proteins from an intracellular vesicular compartment to the cell surface.

1987 • 435 citations

Membrane complement receptor type three (CR3) has lectin-like properties analogous to bovine conglutinin as functions as a receptor for zymosan and rabbit erythrocytes as well as a receptor for iC3b.

1985 • 433 citations

Contributions of the Mac-1 glycoprotein family to adherence-dependent granulocyte functions: structure-function assessments employing subunit-specific monoclonal antibodies.

1986 • 423 citations

Adhesion-promoting receptors on human macrophages recognize Escherichia coli by binding to lipopolysaccharide.

1986 • 415 citations

Human neutrophils increase expression of C3bi as well as C3b receptors upon activation.

1984 • 391 citations

Characterization of the class III collagen receptor, a phosphorylated, transmembrane glycoprotein expressed in nucleated human cells.

1988 • 382 citations

Oligospecificity of the cellular adhesion receptor Mac-1 encompasses an inducible recognition specificity for fibrinogen.

1988 • 374 citations

Heterogeneous mutations in the β subunit common to the LFA-1, Mac-1, and p150,95 glycoproteins cause leukocyte adhesion deficiency

1987 • 373 citations

A novel vitronectin receptor integrin (αvβx) is responsible for distinct adhesive properties of carcinoma cells

1989 • 352 citations

Adhesive protein receptors on hematopoietic cells

1988 • 350 citations

A year in the life of the immunoglobulin superfamily

1987 • 345 citations

Characterization of the cell surface heterodimer VLA-4 and related peptides.

1987 • 340 citations

Increased surface expression of CD11b/CD18 (Mac-1) is not required for stimulated neutrophil adherence to cultured endothelium.

1988 • 333 citations

Functional evidence that intercellular adhesion molecule‐1 (icam‐1) is a ligand for lfa‐1d‐ependent adhesion in t cell‐mediated cytotoxicity

1988 • 322 citations

A Distinct Endothelial Cell Recognition System That Controls Lymphocyte Traffic into Inflamed Synovium

1986 • 317 citations

Macrophage complement and lectin-like receptors bind Leishmania in the absence of serum.

1985 • 306 citations

Inhibition of phagocytosis of complement C3- or immunoglobulin G-coated particles and of C3bi binding by monoclonal antibodies to a monocyte-granulocyte membrane glycoprotein (Mol).

1983 • 303 citations

Evidence for an accessory role of LFA-1 in lymphocyte-high endothelium interaction during homing.

1988 • 302 citations

Detachment of cells from culture substrate by soluble fibronectin peptides.

1985 • 301 citations

Regulated expression of the Mac-1, LFA-1, p150,95 glycoprotein family during leukocyte differentiation.

1986 • 298 citations

Interleukin 1 increases the binding of human B and T lymphocytes to endothelial cell monolayers.

1986 • 296 citations

Evidence for distinct intracellular pools of receptors for C3b and C3bi in human neutrophils.

1985 • 291 citations

Endothelial-leukocyte adhesion molecule-1-dependent and leukocyte (CD11/CD18)-dependent mechanisms contribute to polymorphonuclear leukocyte adhesion to cytokine-activated human vascular endothelium.

1989 • 288 citations

Primary structure of the leukocyte function-associated molecule-1 alpha subunit: an integrin with an embedded domain defining a protein superfamily.

1989 • 285 citations

Association of the VLA a Subunit with a Novel Protein

1989 • 285 citations

The human leukocyte adhesion glycoprotein Mac-1 (complement receptor type 3, CD11b) alpha subunit. Cloning, primary structure, and relation to the integrins, von Willebrand factor and factor B.

1988 • 281 citations

Occupancy of an adhesive glycoprotein receptor modulates expression of an antigenic site involved in cell adhesion.

1988 • 280 citations

Functional and biochemical analysis of CD16 antigen on natural killer cells and granulocytes.

1988 • 280 citations

The saturable high affinity association of factor X to ADP-stimulated monocytes defines a novel function of the Mac-1 receptor.

1988 • 279 citations

cDNA cloning and complete primary structure of the alpha subunit of a leukocyte adhesion glycoprotein, p150,95.

1987 • 277 citations

Neutrophil and monocyte cell surface p150,95 has iC3b-receptor (CR4) activity resembling CR3.

1988 • 266 citations

CR3 (CD11b/CD18) expresses one binding site for Arg-Gly-Asp-containing peptides and a second site for bacterial lipopolysaccharide.

1989 • 264 citations

The primary structure of the alpha 4 subunit of VLA-4: homology to other integrins and a possible cell-cell adhesion function.

1989 • 264 citations

Role of the adherence-promoting receptors, CR3, LFA-1, and p150,95, in binding of Histoplasma capsulatum by human macrophages.

1987 • 259 citations

The monoclonal antibodies alpha S-HCL 1 (alpha Leu-14) and alpha S-HCL 3 (alpha Leu-M5) allow the diagnosis of hairy cell leukemia

1985 • 259 citations

Interaction of fibronectin with its receptor on platelets

1985 • 251 citations

Aggregation of complement receptors on human neutrophils in the absence of ligand.

1987 • 250 citations

An Arg-Gly-Asp-directed receptor on the surface of human melanoma cells exists in an divalent cation-dependent functional complex with the disialoganglioside GD2.

1987 • 246 citations

T lymphocyte adhesion to endothelial cells: mechanisms demonstrated by anti-LFA-1 monoclonal antibodies.

1986 • 246 citations

Complement receptor type 3 (CR3) binds to an Arg-Gly-Asp-containing region of the major surface glycoprotein, gp63, of Leishmania promastigotes.

1988 • 242 citations

The Arg-Gly-Asp binding domain of the vitronectin receptor. Photoaffinity cross-linking implicates amino acid residues 61-203 of the beta subunit.

1988 • 238 citations

Identification of integrin collagen receptors on human melanoma cells

1989 • 237 citations

Specificity of Membrane Complement Receptor Type Three (CR3) for ß-Glucans

1987 • 233 citations

Functional activity of enucleated human polymorphonuclear leukocytes.

1983 • 230 citations

Dynamic membrane-cytoskeletal interactions: specific association of integrin and talin arises in vivo after phorbol ester treatment of peripheral blood lymphocytes.

1988 • 230 citations

Regulatory properties of LFA-1 α and β chains in human T-lymphocyte activation

1988 • 225 citations

Deficiency of a leukocyte surface glycoprotein (LFA-1) in two patients with Mo1 deficiency. Effects of cell activation on Mo1/LFA-1 surface expression in normal and deficient leukocytes.

1984 • 224 citations

LFA-1 and other accessory molecules functioning in adhesions of T and B lymphocytes

1987 • 223 citations

Extracellular matrix receptors, ECMRII and ECMRI, for collagen and fibronectin correspond to VLA-2 and VLA-3 in the VLA family of heterodimers

1988 • 218 citations

Adhesive receptor Mac-1 coordinates the activation of factor X on stimulated cells of monocytic and myeloid differentiation: an alternative initiation of the coagulation protease cascade.

1988 • 215 citations

Lipopolysaccharide priming of human neutrophils for an enhanced respiratory burst. Role of intracellular free calcium.

1989 • 213 citations

Supergene families meet in the immune system

1988 • 213 citations

Phorbol esters cause sequential activation and deactivation of complement receptors on polymorphonuclear leukocytes.

1986 • 206 citations

The monoclonal antibodies alpha S-HCL 1 (alpha Leu-14) and alpha S-HCL 3 (alpha Leu-M5) allow the diagnosis of hairy cell leukemia

1985 • 203 citations

Neutrophil adherence to human endothelium in vitro occurs by CDw18 (Mo1, MAC-1/LFA-1/GP 150,95) glycoprotein-dependent and -independent mechanisms.

1988 • 197 citations

Deficiency of a surface membrane glycoprotein (Mo1) in man.

1984 • 192 citations

Multiple very late antigen (VLA) heterodimers on platelets. Evidence for distinct VLA-2, VLA-5 (fibronectin receptor), and VLA-6 structures.

1988 • 186 citations

Platelet glycoprotein IIb-IIIa-like proteins mediate endothelial cell attachment to adhesive proteins and the extracellular matrix.

1987 • 185 citations

Monoclonal antibodies against the CD44 [In(Lu)-related p80], and Pgp-1 antigens in man recognize the Hermes class of lymphocyte homing receptors.

1989 • 183 citations

Two functional domains in the phagocyte membrane glycoprotein Mo1 identified with monoclonal antibodies.

1986 • 174 citations

Monoclonal antibody-defined functional epitopes on the adhesion- promoting glycoprotein complex (CDw18) of human neutrophils

1986 • 173 citations

Fibronectin receptors of phagocytes. Characterization of the Arg-Gly-Asp binding proteins of human monocytes and polymorphonuclear leukocytes.

1988 • 168 citations

Competition for related but nonidentical binding sites on the glycoprotein IIb-IIIa complex by peptides derived from platelet adhesive proteins

1987 • 168 citations

Roles of CR3 and mannose receptors in the attachment and ingestion of Leishmania donovani by human mononuclear phagocytes

1988 • 165 citations

Modulation of FcR function by complement: subcomponent C1q enhances the phagocytosis of IgG-opsonized targets by human monocytes and culture-derived macrophages.

1987 • 165 citations

The very late antigen family of heterodimers is part of a superfamily of molecules involved in adhesion and embryogenesis.

1987 • 164 citations

C3bi receptor (complement receptor type 3) recognizes a region of complement protein C3 containing the sequence Arg-Gly-Asp.

1987 • 163 citations

Relative contribution of the leukocyte molecules MO1, LFA‐1, and p150,95 (LeuM5) in adhesion of granulocytes and monocytes to vascular endothelium is tissue‐ and stimulus‐specific

1988 • 162 citations

Up-regulation of the iC3b receptor (CR3) is neither necessary nor sufficient to promote neutrophil aggregation.

1988 • 161 citations

Stimulation of eosinophil adherence to human vascular endothelial cells in vitro by platelet-activating factor.

1988 • 159 citations

Dissociation between increased surface expression of gp165/95 and homotypic neutrophil aggregation.

1988 • 156 citations

Leukocyte Adhesion Deficiency

1989 • 153 citations

Isolation and characterization of a platelet surface collagen binding complex related to VLA-2

1988 • 152 citations

pl50/95, Third member of the LFA‐1/CR₃ polypeptide family identified by anti‐Leu M5 monoclonal antibody

1985 • 149 citations

The p150,95 molecule is a marker of human mononuclear phagocytes: Comparison with expression of class II molecules

1986 • 146 citations

CD11a-c/CD18 and GP84 (LB-2) adhesion molecules on human large granular lymphocytes and their participation in natural killing.

1988 • 143 citations

DELAYED SEPARATION OF THE UMBILICAL CORD, WIDESPREAD INFECTIONS, AND DEFECTIVE NEUTROPHIL MOBILITY

1979 • 143 citations

An immobile subset of plasma membrane CD11b/CD18 (Mac-1) is involved in phagocytosis of targets recognized by multiple receptors.

1989 • 141 citations

Connective tissue proteins and phagocytic cell function. Laminin enhances complement and Fc-mediated phagocytosis by cultured human macrophages.

1985 • 127 citations

p150,95, the third member of the Mac-1, LFA-1 human leukocyte adhesion glycoprotein family.

1986 • 125 citations

Mechanism of inhibition of immunoglobulin G-mediated phagocytosis by monoclonal antibodies that recognize the Mac-1 antigen.

1988 • 125 citations

Migration of neutrophils across monolayers of cultured microvascular endothelial cells An in vitro model of leucocyte extravasation

1987 • 121 citations

Tissue-specific phosphorylation of complement receptors CR1 and CR2.

1986 • 115 citations

The lymphocyte function-associated antigen (LFA)-1 and CD2/LFA-3 pathways of antigen-independent human T cell adhesion.

1987 • 112 citations

Communication between receptors for different ligands on a single cell: ligation of fibronectin receptors induces a reversible alteration in the function of complement receptors on cultured human monocytes.

1984 • 112 citations

Chromosomal location of the genes encoding the leukocyte adhesion receptors LFA-1, Mac-1 and p150,95. Identification of a gene cluster involved in cell adhesion.

1988 • 112 citations

Studies on the fibronectin receptors of human peripheral blood leukocytes. Morphologic and functional characterization.

1984 • 111 citations

Lymphoid tissue- and inflammation-specific endothelial cell differentiation defined by monoclonal antibodies.

1987 • 110 citations

Suppressor effects and cyclic AMP accumulation by the CD29 molecule of CD4+ lymphocytes

1989 • 109 citations

Electron microscopic study of rheumatoid synovial vasculature. Intimate relationship between tall endothelium and lymphoid aggregation.

1986 • 108 citations

Isolation of complement-fragment-iC3b-binding proteins by affinity chromatography. The identification of p150,95 as an iC3b-binding protein

1985 • 106 citations

Role of the LFA-1 molecule in cellular interactions required for antibody production in humans.

1986 • 105 citations

Membrane glycoprotein p150,95 of human cytotoxic T cell clone is involved in conjugate formation with target cells.

1987 • 103 citations

Intracellular location of T200 and Mo1 glycoproteins in human neutrophils.

1988 • 102 citations

Characterization of patients with an increased susceptibility to bacterial infections and a genetic deficiency of leukocyte membrane complement receptor type 3 and the related membrane antigen LFA-1

1985 • 98 citations

Phosphorylation of T cell membrane proteins by activators of protein kinase C.

1988 • 96 citations

Ligand binding by the pl50,95 antigen of U937 monocytic cells: properties in common with complement receptor type 3 (CR3)

1986 • 93 citations

Fibronectin-binding properties of the purified platelet glycoprotein IIb-IIIa complex.

1986 • 93 citations

LFA-1 membrane molecule in the regulation of homotypic adhesions of human B lymphocytes.

1985 • 93 citations

Identification and characterization of a novel antigen complex on mouse mammary tumor cells using a monoclonal antibody against platelet glycoprotein Ic.

1988 • 88 citations

Differential function of LFA-1 family molecules (CD11 and CD18) in adhesion of human monocytes to melanoma and endothelial cells.

1987 • 86 citations

Association between gelatinase release and increased plasma membrane expression of the Mo1 glycoprotein.

1987 • 86 citations

Identification and function of the high affinity binding sites for Ca2+ on the surface of platelets.

1984 • 85 citations

Heritable lymphocyte function-associated antigen-1 deficiency: abnormalities of cytotoxicity and proliferation associated with abnormal expression of LFA-1.

1985 • 83 citations

The role of monocyte lymphocyte function‐associated antigen 1 (LFA‐1) in accessory cell function

1987 • 77 citations

Induction of calcium flux and enhancement of cytolytic activity in natural killer cells by cross-linking of the sheep erythrocyte binding protein (CD2) and the Fc-receptor (CD16).

1987 • 74 citations

Influence of quaternary structure on glycosylation. Differential subunit association affects the site-specific glycosylation of the common beta-chain from Mac-1 and LFA-1.

1986 • 74 citations

Interferon-gamma induction of LFA-1-mediated homotypic adhesion of human monocytes.

1986 • 72 citations

Functional role of the alpha-chain of complement receptor type 3 in human eosinophil-dependent antibody-mediated cytotoxicity against schistosomes.

1987 • 71 citations

Leukocytes from four patients with complete or partial Leu-CAM deficiency contain the common beta-subunit precursor and beta-subunit messenger RNA.

1987 • 71 citations

Adherence of human basophils to cultured umbilical vein endothelial cells.

1988 • 68 citations

Modulation of surface glycoproteins (Mo1, LFA-1, p150,95) by human mononuclear phagocytes

1988 • 61 citations

Synergism between membrane gangliosides and Arg-Gly-Asp-directed glycoprotein receptors in attachment to matrix proteins by melanoma cells.

1988 • 61 citations

Co‐expression of Mac‐1 and p150,95 on CD5⁺ B cells. Structural and functional characterization in a human chronic lymphocytic leukemia

1988 • 60 citations

Membrane glycoproteins of human polymorphonuclear leukocytes that act as receptors for mannose-specific Escherichia coli

1987 • 60 citations

A monoclonal antibody against altered LFA‐1 induces proliferation and lymphokine release of cloned T cells

1986 • 57 citations

Alpha and beta subunits of the LFA‐1 membrane molecule are involved in human monocyte–endothelial cell adhesion

1987 • 54 citations

Immunologic studies with LFA-1- and Mo1-deficient lymphocytes from a patient with recurrent bacterial infections.

1985 • 52 citations

Phagocytosis of Particulate Activators of the Alternative Complement Pathway: Effects of Fibronectin

1986 • 50 citations

The role of lymphocyte function‐associated antigen 1 (LFA‐1) in the adherence of T lymphocytes to B lymphocytes

1988 • 49 citations

Vitronectin (S protein) augments the functional activity of monocyte receptors for IgG and complement C3b

1988 • 49 citations

Complement C3 receptors: Structure and function

1984 • 46 citations

The elevated natural killer sensitivity of targets carrying surface-attached C3 fragments require the availability of the iC3b receptor (CR3) on the effectors.

1988 • 45 citations

Tyrosine 70 increases the coenzyme affinity of aspartate aminotransferase. A site-directed mutagenesis study.

1987 • 45 citations

Regulatory interactions between members of the immunoglobulin superfamily

1988 • 42 citations

Neutrophil C3bi receptors: Formation of membrane clusters during cell triggering requires intracellular granules

1987 • 41 citations

The effect of fibronectin on the processing of C1q- and C3b/bi-coated immune complexes by peripheral blood monocytes.

1986 • 41 citations

Perturbation of beta-glucan receptors on human neutrophils initiates phagocytosis and leukotriene B4 production.

1988 • 37 citations

Aberrant activation and regulation of the oxidative burst in neutrophils with Mol glycoprotein deficiency.

1986 • 27 citations

Mapping functional epitopes of the human LFA-1 glycoprotein: Monoclonal antibody ingibition of NK and CTL effectors

1986 • 25 citations

Involvement in the initiation of T cell responses and structural features of an 85‐kDa membrane activation antigen

1988 • 24 citations

Augmentation of lymphocyte responses by monoclonal antibodies to the gangliosides GD3 and GD2: The role of protein kinase C, cyclic nucleotides, and intracellular calcium

1989 • 23 citations

Glycoprotein-180 deficiency: genetics and abnormal neutrophil activation

1985 • 20 citations

CD4 is involved in a post-binding event in the cytolytic reaction mediated by human CD4+ cytotoxic T lymphocyte clones.

1988 • 20 citations

Interaction of Thrombin-Stimulated Platelets with Vitronectin (S-Protein of Complement) Substrate: Inhibition by a Monoclonal Antibody to Glycoprotein IIb-IIIa Complex

1988 • 19 citations

The neutrophil glycoprotein Mo1 is an integral membrane protein of plasma membranes and specific granules.

1987 • 17 citations

Identification of a structure on human melanoma cells recognized by CTL exhibiting anomalous killer cell function.

1985 • 17 citations

Importance of an 85 kDa membrane glycoprotein for a variety of cell-cell interactions

1988 • 17 citations

Differences between Primed Allogeneic T‐Cell Responses and the Primary Mixed Leucocyte Reaction

1988 • 15 citations

Involvement of “accessory” and antigen receptor molecules in human helper T cell clone activation studied by monoclonal antibody inhibition

1989 • 3 citations