The origin of remyelinating cells in the central nervous system

A glial progenitor cell that develops in vitro into an astrocyte or an oligodendrocyte depending on culture medium

1983 • 2,009 citations

Monoclonal antibodies (O1 to O4) to oligodendrocyte cell surfaces: An immunocytological study in the central nervous system

1981 • 1,131 citations

Co-localization of NG2 proteoglycan and PDGF ?-receptor on O2A progenitor cells in the developing rat brain

1996 • 620 citations

Endogenous Progenitors Remyelinate Demyelinated Axons in the Adult CNS

1997 • 539 citations

Repair of demyelinated lesions by transplantation of purified 0-2A progenitor cells

1993 • 441 citations

Patterns of oligodendroglia pathology in multiple sclerosis

1994 • 403 citations

Proliferating bipotential glial progenitor cells in adult rat optic nerve

1986 • 378 citations

Response of the oligodendrocyte progenitor cell population (defined by NG2 labelling) to demyelination of the adult spinal cord

1998 • 342 citations

Central nervous system demyelination and remyelination in the mouse: an ultrastructural study of cuprizone toxicity.

1978 • 293 citations

Pre-oligodendrocytes from adult human CNS

1992 • 267 citations

Multiple sclerosis. Oligodendrocyte proliferation and differentiation in fresh lesions.

1989 • 266 citations

Multiple sclerosis. Oligodendrocyte survival and proliferation in an active established lesion.

1981 • 263 citations

Identification of Post-mitotic Oligodendrocytes Incapable of Remyelination within the Demyelinated Adult Spinal Cord

1997 • 262 citations

Oligodendroglial progenitors labeled with the O4 antibody persist in the adult rat cerebral cortex in vivo

1997 • 255 citations

In situ demonstration of mature oligodendrocytes and their processes: An immunocytochemical study with a new monoclonal antibody, Rip

1989 • 252 citations

Interaction between NG2 proteoglycan and PDGF ?-receptor on O2A progenitor cells is required for optimal response to PDGF

1996 • 236 citations

Cooperation between PDGF and FGF converts slowly dividing O-2Aadult progenitor cells to rapidly dividing cells with characteristics of O-2Aperinatal progenitor cells.

1992 • 230 citations

Oligodendrocytes in the early course of multiple sclerosis

1994 • 215 citations

Immunoglobulins promote remyelination in the central nervous system

1990 • 211 citations

Demyelination of the superior cerebellar peduncle in the mouse induced by cuprizone

1973 • 205 citations

Observations on oligodendrocyte degeneration, the resolution of status spongiosus and remyelination in cuprizone intoxication in mice

1972 • 204 citations

Local recruitment of remyelinating cells in the repair of demyelination in the central nervous system

1997 • 187 citations

Plasticity of developing cerebellar cells in vitro studied with antibodies against the NG2 antigen

1987 • 183 citations

Proliferation of mature oligodendrocytes after trauma to the central nervous system

1984 • 179 citations

In vitro analysis of the origin and maintenance of O-2Aadult progenitor cells.

1992 • 144 citations

Expression of the Highly Polysialylated Neural Cell Adhesion Molecule During Postnatal Myelination and Following Chemically Induced Demyelination of the Adult Mouse Spinal Cord

1995 • 136 citations

FGF-2 converts mature oligodendrocytes to a novel phenotype

1997 • 128 citations

Plasticity in the adult human oligodendrocyte lineage

1994 • 122 citations

Identification of the adult resting progenitor cell by autoradiographic tracking of oligodendrocyte precursors in experimental CNS demyelination

1998 • 122 citations

Division of astroblasts and oligodendroblasts in postnatal rodent brain: Evidence for separate astrocyte and oligodendrocyte lineages

1991 • 120 citations

An autoradiographic study of cellular proliferation in remyelination of the central nervous system.

1979 • 116 citations

A proliferative adult human oligodendrocyte progenitor

1995 • 114 citations

Evidence that axons are mitogenic for oligodendrocytes isolated from adult animals

1986 • 113 citations

Suppression of remyelination in the CNS by X-irradiation

1978 • 111 citations

Early recruitment of oligodendrocyte precursors in CNS demyelination

1994 • 109 citations

Mature Oligodendrocytes

1984 • 108 citations

Failure to achieve remyelination of demyelinated rat axons following transplantation of glial cells obtained from the adult human brain

1996 • 95 citations

Coexistence of perinatal and adult forms of a glial progenitor cell during development of the rat optic nerve

1990 • 94 citations

The Pathological and Clinical Dynamics of Multiple Sclerosis

1994 • 87 citations

The Potential for Oligodendrocyte Proliferation During Demyelinating Disease

1993 • 85 citations

Transplanting oligodendrocyte progenitors into the adult CNS

1997 • 82 citations

The demonstration of recurrent demyelination and remyelination of axons in the central nervous system

1981 • 81 citations

Can oligodendrocytes attached to myelin proliferate?

1988 • 77 citations

Immunoreactivity of Cyclin D1/cdk4 in Neurons and Oligodendrocytes After Focal Cerebral Ischemia in Rat

1997 • 76 citations

Distribution and morphological characteristics of oligodendrocytes in the rat hippocampusin situ andin vitro: an immunocytochemical study with the monoclonal Rip antibody

1994 • 69 citations

Growth factor stimulation triggers apoptotic cell death in mature oligodendrocytes

1996 • 68 citations

Immunoglobulins stimulate central nervous system remyelination: electron microscopic and morphometric analysis of proliferating cells.

1991 • 66 citations

Differentiation and proliferation: Two possible mechanisms for the regeneration of oligodendrocytes in culture

1982 • 51 citations

THE ORIGIN OF REMYELINATING OLIGODENDROCYTES IN ANTISERUM-MEDIATED DEMYELINATIVE OPTIC NEUROPATHY

1990 • 49 citations

Glial cell transplants that are subsequently rejected can be used to influence regeneration of glial cell environments in the CNS

1995 • 48 citations

Myelination by mature ovine oligodendrocytes in vivo and in vitro: Evidence that different steps in the myelination process are independently controlled

1993 • 26 citations

Oligodendrocyte precursor quantitation and localization in perinatal brain using a retrospective bioassay

1994 • 25 citations

Myelin Palingenesis (Part 1 of 2)

1992 • 16 citations

Rejection of wild-type and genetically engineered major histocompatibility complex-deficient glial cell xenografts in the central nervous system results in bystander demyelination and Wallerian degeneration

1998 • 7 citations