Expression of the Three Alternative Forms of the Sphingolipid Activator Protein Precursor in Baby Hamster Kidney Cells and Functional Assays in a Cell Culture System

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Measurement of protein using bicinchoninic acid

1985 • 17,516 citations

Gangliosides of human, bovine, and rabbit plasma

1972 • 354 citations

Activator proteins and topology of lysosomal sphingolipid catabolism

1992 • 269 citations

Coding of Two Sphingolipid Activator Proteins (SAP-1 and SAP-2) by Same Genetic Locus

1988 • 251 citations

A simple and novel method for tritium labeling of gangliosides and other sphingolipids

1978 • 250 citations

Identification of prosaposin as a neurotrophic factor.

1994 • 228 citations

A Sulfated Glycoprotein Synthesized by Sertoli Cells and by Epididymal Cells is a Component of the Sperm Membrane 1

1984 • 226 citations

Modulation of DNA Binding Specificity by Alternative Splicing of the Wilms Tumor wt1 Gene Transcript

1992 • 221 citations

Specific radioactive labeling of terminal N-acetylgalactosamine of glycosphingolipids by the galactose oxidase–sodium borohydride method

1972 • 207 citations

Saposin-like proteins (SAPLIP) carry out diverse functions on a common backbone structure.

1995 • 205 citations

Sphingolipid activator protein deficiency in a 16-week-old atypical Gaucher disease patient and his fetal sibling: Biochemical signs of combined sphingolipidoses

1989 • 199 citations

Expression in mammalian cells of a gene fromStreptomyces albonigerconferring puromycin resistance

1986 • 183 citations

Vectors for efficient expression in mammalian fibroblastoid, myeloid and lymphoid cells via transfection or infection

1988 • 170 citations

Immunochemical Characterization of Two Activator Proteins Stimulating Enzymic Sphingomyelin Degradation in vitro Absence of One of them in a Human Gaucher Disease Variant

1986 • 164 citations

Sphingolipid Activator Protein D (sap-D) Stimulates the Lysosomal Degradation of Ceramide in Vivo

1994 • 154 citations

Simultaneous deficiency of sphingolipid activator proteins 1 and 2 is caused by a mutation in the initiation codon of their common gene.

1992 • 149 citations

Structure of Full-Length cDNA Coding for Sulfatide Activator, a Co-β-Glucosidase and Two Other Homologous Proteins: Two Alternate Forms of the Sulfatide Activator1

1989 • 134 citations

Prosaposin deficiency: further characterization of the sphingolipid activator protein-deficient sibs

1993 • 128 citations

Saposin A: second cerebrosidase activator protein.

1989 • 126 citations

Identification of the neurotrophic factor sequence of prosaposin

1995 • 123 citations

Binding and transport of gangliosides by prosaposin.

1992 • 115 citations

The Precursor of Sulfatide Activator Protein is Processed to Three Different Proteins

1988 • 114 citations

Isolation, Characterization, and Proteolysis of Human Prosaposin, the Precursor of Saposins (Sphingolipid Activator Proteins)

1993 • 101 citations

Protection by Prosaposin Against Ischemia-Induced Learning Disability and Neuronal Loss

1994 • 99 citations

Functional differences between the two splice variants of the nucleolar transcription factor UBF: the second HMG box determines specificity of DNA binding and transcriptional activity.

1994 • 98 citations

Sulfatide activator protein. Alternative splicing that generates three mRNAs and a newly found mutation responsible for a clinical disease.

1991 • 96 citations

Diagnosis of Metachromatic Leukodystrophy, Krabbe Disease, and Farber Disease after Uptake of Fatty Acid-labeled Cerebroside Sulfate into Cultured Skin Fibroblasts

1982 • 77 citations

Two procedures to remove polar contaminants from a crude brain lipid extract by using prepacked reversed‐phase columns

1987 • 76 citations

Isolation of overproducing recombinant mammalian cell lines by a fast and simple selection procedure

1988 • 75 citations

Isolation and characterization of prosaposin from human milk

1991 • 67 citations

Insertion in the mRNA of a metachromatic leukodystrophy patient with sphingolipid activator protein-1 deficiency.

1990 • 66 citations

Sphingolipid activator protein 1 deficiency in metachromatic leucodystrophy with normal arylsulphatase A activity. A clinical, morphological, biochemical and immunological study

1991 • 64 citations

Additional biochemical findings in a patient and fetal sibling with a genetic defect in the sphingolipid activator protein (SAP) precursor, prosaposin. Evidence for a deficiency in SAP-1 and for a normal lysosomal neuraminidase

1992 • 60 citations

Synthesis and processing of sphingolipid activator protein-2 (SAP-2) in cultured human fibroblasts.

1986 • 59 citations

The complete amino‐acid sequences of human ganglioside GM2 activator protein and cerebroside sulfate activator protein

1990 • 58 citations

The activator protein for glucosylceramide beta-glucosidase from guinea pig liver. Improved isolation method and complete amino acid sequence.

1988 • 55 citations

The organization of the gene for the human cerebroside sulfate activator protein

1991 • 48 citations

The mechanism for a 33-nucleotide insertion in mRNA causing sphingolipid activator protein (SAP-1)-deficient metachromatic leukodystrophy

1991 • 42 citations

Analysis of a splice-site mutation in the sap-precursor gene of a patient with metachromatic leukodystrophy.

1996 • 29 citations

Differential segregation of human and hamster cathepsin D in transfected baby-hàmster kidney cells

1991 • 29 citations

Effect of saposins on acid sphingomyelinase

1993 • 28 citations

Release of Sphingomyelin Phosphodiesterase (Acid Sphingomyelinase) by Ammonium Chloride from CL 1D Mouse L-Cells and Human Fibroblasts. Partial Purification and Characterization of the Exported Enzymes

1983 • 24 citations

Modulation of human saposin B sphingolipid-binding specificity by alternative splicing. A study with saposin B-derived synthetic peptides.

1994 • 21 citations

Structure of the lysosomal sphingolipid activator protein 1 by homology with influenza virus neuraminidase

1988 • 21 citations

Regional localization of the gene coding for sphingolipid activator protein SAP-1 on human chromosome 10

1987 • 18 citations

Porcine cerebroside sulfate activator: Further structural characterization and disulfide identification

1993 • 17 citations

Structural study of the oligosaccharide moieties of sphingolipid activator proteins, saposins A, C and D obtained from the spleen of a Gaucher patient

1993 • 17 citations

Characteristics of asparagine-linked sugar chains of sphingolipid activator protein 1 purified from normal human liver and GM1 gangliosidosis (type 1) liver

1990 • 16 citations

The primary structure of mouse saposin

1992 • 16 citations

Compartmentalized gene expression during sporulation in Bacillus subtilis

1991 • 13 citations