Bradykinin and Phorbol Dibutyrate Activate Phospholipase D in PC12 Cells by Different Mechanisms

Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor.

1976 • 5,526 citations

Methods in enzymology, vol. 127

1987 • 1,134 citations

Staurosporine, K-252 and UCN-01: potent but nonspecific inhibitors of protein kinases

1989 • 905 citations

Lysophosphatidate-induced cell proliferation: Identification and dissection of signaling pathways mediated by G proteins

1989 • 846 citations

Growth factor-like action of phosphatidic acid

1986 • 531 citations

Rapid formation of diacylglycerol from phosphatidylcholine: a pathway for generation of a second messenger.

1986 • 415 citations

Phosphatidylethanol Formation via Transphosphatidylation by Rat Brain Synaptosomal Phospholipase D

1987 • 342 citations

Phospholipase D catalyzes phospholipid metabolism in chemotactic peptide-stimulated HL-60 granulocytes.

1988 • 307 citations

Proposed mechanism of cholinergic action in smooth muscle

1980 • 256 citations

Phosphatidylcholine breakdown in rat liver plasma membranes. Roles of guanine nucleotides and P2-purinergic agonists.

1987 • 253 citations

Regulation of Phospholipase D in HL-60 Granulocytes

1989 • 250 citations

Second messengers involved in the mechanism of action of bradykinin in sensory neurons in culture

1989 • 249 citations

Phorbol ester and 1-oleoyl-2-acetylglycerol inhibit angiotensin activation of phospholipase C in cultured vascular smooth muscle cells.

1985 • 240 citations

Down regulation of protein kinase C in neuronal cells: effects on neurotransmitter release

1987 • 204 citations

Long-term phorbol ester treatment down-regulates protein kinase C and sensitizes the phosphoinositide signaling pathway to hormone and growth factor stimulation. Evidence for a role of protein kinase C in agonist-induced desensitization.

1988 • 186 citations

P2-Purinergic Agonists Stimulate Phosphodiesteratic Cleavage of Phosphatidylcholine in Endothelial Cells

1989 • 180 citations

Phorbol myristate acetate inhibits thrombin-stimulated Ca2+ mobilization and phosphatidylinositol 4,5-bisphosphate hydrolysis in human platelets.

1985 • 179 citations

Gonadotropin-releasing hormone activates phospholipase D in ovarian granulosa cells

1989 • 168 citations

Phosphatidylethanol Biosynthesis in Ethanol-exposed NG108-15 Neuroblastoma X Glioma Hybrid Cells

1989 • 151 citations

Muscarinic Receptor Activation of Phosphatidylcholine Hydrolysis

1989 • 146 citations

Stimulation of phosphatidic acid of calcium influx and cyclic GMP synthesis in neuroblastoma cells.

1981 • 135 citations

Phorbol diesters stimulate the accumulation of phosphatidate, phosphatidylethanol, and diacylglycerol in three cell types. Evidence for the indirect formation of phosphatidylcholine-derived diacylglycerol by a phospholipase D pathway and direct formation of diacylglycerol by a phospholipase C pathway.

1990 • 113 citations

Rapid protein kinase C-dependent activation of phospholipase D leads to delayed 1,2-diglyceride accumulation.

1990 • 110 citations

Differential hydrolysis of phospholipid molecular species during activation of human platelets with thrombin and collagen.

1987 • 102 citations

Alterations of Lipid Metabolism in Response to Nerve Growth Factor

1982 • 97 citations

Phosphatidate as a Molecular Link Between Depolarization and Neurotransmitter Release in the Brain

1981 • 95 citations

Phospholipase D in homogenates from HL-60 granulocytes: Implications of calcium and G protein control

1989 • 91 citations

12-O-tetradecanoylphorbol-13-acetate activates phosphatidylethanol and phosphatidylglycerol synthesis by phospholipase D in cell lysates

1988 • 78 citations

Evidence for a protein kinase C‐directed mechanism in the phorbol diester‐induced phospholipase D pathway of diacylglycerol generation from phosphatidylcholine

1989 • 74 citations

Fundamentals of Behavioral Statistics.

1981 • 71 citations

Phospholipids containing polyunsaturated fatty acyl groups are mitogenic for normal mouse mammary epithelial cells in serum-free primary cell culture.

1989 • 62 citations

Insulin and Insulin-Like Growth Factors Stimulate Deoxyribonucleic Acid Synthesis in PC 12 Pheochromocytoma Cells

1988 • 60 citations

Evidence for protein kinase C independent activation of phospholipase D by phorbol esters in lymphocytes

1990 • 47 citations

Hydrolysis of Endogenous Phospholipids by Rat Brain Microsomes

1985 • 45 citations

Bradykinin Activates a Phospholipase D that Hydrolyzes Phosphatidylcholine in PC12 Cells

1991 • 39 citations

Long-term phorbol ester treatment dissociates phospholipase D activation from phosphoinositide hydrolysis and prostacyclin synthesis in endothelial cells stimulated with bradykinin

1989 • 35 citations

Guanine Nucleotide‐Binding Protein Regulation of Microsomal Phospholipase D Activity of Canine Cerebral Cortex

1990 • 33 citations

Phosphorylation of tyrosine hydroxylase in protein kinase C-deficient PC12 cells

1989 • 29 citations

Carbachol and Bradykinin Increase the Production of Diacylglycerol from Sources Other than Inositol‐Containing Phospholipids in PC12 Cells

1990 • 28 citations

Choline acetyltransferase-like activity bound to neuronal plasma membranes

1988 • 14 citations