Bone Marrow Adipocytes: A Neglected Target Tissue for Growth Hormone

Multilineage Potential of Adult Human Mesenchymal Stem Cells

1999 • 20,447 citations

Osteogenic differentiation of purified, culture-expanded human mesenchymal stem cells in vitro

1997 • 2,492 citations

Bone Marrow, Cytokines, and Bone Remodeling — Emerging Insights into the Pathophysiology of Osteoporosis

1995 • 1,661 citations

Physiological role of adipose tissue: white adipose tissue as an endocrine and secretory organ

2001 • 1,216 citations

Liver-derived insulin-like growth factor I (IGF-I) is the principal source of IGF-I in blood but is not required for postnatal body growth in mice

1999 • 938 citations

Human Growth Hormone and Human Aging

1993 • 874 citations

Growth Hormone and Bone*

1998 • 807 citations

Adult Human Mesenchymal Stem Cell Differentiation to the Osteogenic or Adipogenic Lineage Is Regulated by Mitogen-activated Protein Kinase

2000 • 749 citations

Osteoporosis and the Replacement of Cell Populations of the Marrow by Adipose Tissue

1971 • 743 citations

Leptin Acts on Human Marrow Stromal Cells to Enhance Differentiation to Osteoblasts and to Inhibit Differentiation to Adipocytes¹

1999 • 712 citations

Clinical Aspects of Growth Hormone Deficiency in Adults

1995 • 690 citations

Effect of Growth Hormone on Carbohydrate and Lipid Metabolism

1987 • 584 citations

Evidence that intermittent treatment with parathyroid hormone increases bone formation in adult rats by activation of bone lining cells.

1995 • 580 citations

A dual effector theory of growth-hormone action

1985 • 512 citations

Sex Steroids and Bone

2001 • 484 citations

Changes in trabecular bone, hematopoiesis and bone marrow vessels in aplastic anemia, primary osteoporosis, and old age: A comparative histomorphometric study

1987 • 450 citations

Differential Roles for Bone Morphogenetic Protein (BMP) Receptor Type IB and IA in Differentiation and Specification of Mesenchymal Precursor Cells to Osteoblast and Adipocyte Lineages

1998 • 379 citations

Overexpression of ΔFosB transcription factor(s) increases bone formation and inhibits adipogenesis

2000 • 333 citations

Is there a therapeutic opportunity to either prevent or treat osteopenic disorders by inhibiting marrow adipogenesis?

2000 • 281 citations

Growth hormone-deficient dwarfism in the rat: a new mutation

1988 • 239 citations

Increased Adipogenesis and Myelopoiesis in the Bone Marrow of SAMP6, a Murine Model of Defective Osteoblastogenesis and Low Turnover Osteopenia

1997 • 232 citations

Growth hormone stimulates proliferation and differentiation of normal human osteoblast-like cells in vitro

1993 • 207 citations

High expression of leptin by human bone marrow adipocytes in primary culture

1998 • 204 citations

Osteoblasts Are a New Target for Prolactin: Analysis of Bone Formation in Prolactin Receptor Knockout Mice**This work was supported in part by grants from Hoechst Marion Roussel, Inc.

1999 • 187 citations

Short and long‐term effects of growth hormone treatment on bone turnover and bone mineral content in adult growth hormone‐deficient males*

1993 • 180 citations

Comparison of the effects of intermittent and continuous administration of human parathyroid hormone(1?34) on rat bone

1995 • 159 citations

Age-related variations of fat tissue fraction in normal human bone marrow depend both on size and number of adipocytes: a stereological study.

1989 • 141 citations

Growth Hormone (GH) Receptors in Clonal Osteoblast Like Cells Mediate a Mitogenic Response to GH*

1991 • 139 citations

Relationships between marrow fat and bone turnover in ovariectomized and intact rats

1991 • 130 citations

Body fat distribution, the menopause transition, and hormone replacement therapy.

2000 • 128 citations

Interleukin-6-type cytokines stimulate mesenchymal progenitor differentiation toward the osteoblastic lineage.

1998 • 125 citations

Gender Differences in the Effects of Long Term Growth Hormone (GH) Treatment on Bone in Adults with GH Deficiency¹

1999 • 114 citations

Differential Effects of Growth Hormone and Insulin-Like Growth Factor I on Colony Formation of Epiphyseal Chondrocytes in Suspension Culture in Rats of Different Ages*

1987 • 112 citations

Prolonged treatment with recombinant insulin-like growth factor-I in children with growth hormone insensitivity syndrome--a clinical research center study. GHIS Collaborative Group.

1996 • 112 citations

The function of adipocytes in the bone marrow stroma.

1990 • 109 citations

Characterization of the Inhibitory Effect of Growth Hormone on Primary Preadipocyte Differentiation

1998 • 108 citations

Adipose tissue assessed by magnetic resonance imaging in growth hormone-deficient adults: the effect of growth hormone replacement and a comparison with control subjects

1995 • 96 citations

Age-Associated Loss of Bone Marrow Hematopoietic Cells Is Reversed by GH and Accompanies Thymic Reconstitution

2002 • 86 citations

Reduced Expression of Interleukin-11 in Bone Marrow Stromal Cells of Senescence-Accelerated Mice (SAMP6): Relationship to Osteopenia with Enhanced Adipogenesis

1998 • 79 citations

Expression and Regulation of Growth Hormone (GH) Receptor Messenger Ribonucleic Acid (mRNA) in Rat Adipose Tissue, Adipocytes, and Adipocyte Precursor Cells: GH Regulation of GH Receptor mRNA^*

1991 • 77 citations

Effects of in vivo estrogen treatment on adipose tissue metabolism and nuclear estrogen receptor binding in isolated rat adipocytes

1992 • 76 citations

Pubertal development and testicular function in the male growth hormone-deficient rat

1990 • 74 citations

Growth, growth hormone (GH)-binding protein, and GH receptors are differentially regulated by peak and trough components of the GH secretory pattern in the rat.

1996 • 68 citations

Growth hormone stimulates proliferation of normal human bone marrow stromal osteoblast precursor cells in vitro.

1994 • 66 citations

PRL Receptor-Mediated Effects in Female Mouse Adipocytes: PRL Induces Suppressors of Cytokine Signaling Expression and Suppresses Insulin-Induced Leptin Production in Adipocytes in Vitro

2001 • 60 citations

Prolactin receptor expression during adipocyte differentiation of bone marrow stroma.

1996 • 58 citations

Hormonal changes affect the bone and bone marrow cells in a rat model

2000 • 52 citations

Treatment of Growth Hormone Deficiency in Adults

2000 • 52 citations

Efficient Fat Storage in Premenopausal Women and in Early Pregnancy: A Role for Estrogen

2001 • 49 citations

The Haematopoietic Effects of Growth Hormone and Insulin-like Growth Factor-I

1998 • 49 citations

The Treatment of Growth Hormone Deficiency in Adults

2000 • 48 citations

The effects of growth hormone on cortical and cancellous bone.

2001 • 44 citations

Microcytophotometric analysis of human osteoclast metabolism: lack of activity in certain oxidative pathways indicates inability to sustain biosynthesis during resorption.

1994 • 40 citations

The obese growth hormone (GH)-deficient dwarf rat: body fat responses to patterned delivery of GH and insulin-like growth factor-I.

1996 • 40 citations

Growth Hormone Treatment of Hypophysectomized Rats Increases Catecholamine‐induced Lipolysis and the Number of β‐Adrenergic Receptors in Adipocytes: No Differences in the Effects of Growth Hormone on Different Fat Depots

1996 • 37 citations

Effect of 16 Months of Treatment with Tibolone on Bone Mass, Turnover, and Biomechanical Quality in Mature Ovariectomized Rats

2001 • 37 citations

Bioactivity of Parathyroid Hormone and Parathyroid Hormone-Like Peptide: Agonist and Antagonist Activities of Amino-Terminal Fragments as Assessed by the Cytochemical Bioassay and in Situ Biochemistry*

1991 • 35 citations

Relationship between the location of osteoblastic alkaline phosphatase activity and bone formation in human iliac crest bone

1992 • 31 citations

Regulation of testicular insulin-like growth factor-I in pubertal growth hormone-deficient male rats

1991 • 29 citations

Cortical Remodeling Following Suppression of Endogenous Estrogen with Analogs of Gonadotrophin Releasing Hormone

1997 • 27 citations

Single cell enzyme activity and proliferation in the growth plate: Effects of growth hormone

1996 • 21 citations

Subpopulations of Stromal Cells from Long‐term Human Bone Marrow Cultures: Ontogeny of Progenitor Cells and Expression of Growth Hormone Receptors *

1997 • 13 citations

Growth Hormone, Osteoblasts, and Marrow Adipocytes: A Case Report

1997 • 13 citations

Differential phosphorylation of Janus kinase 2, Stat5A and Stat5B in response to growth hormone in primary rat adipocytes

2001 • 7 citations