Aqueous Dissolution of Alzheimer's Disease Aβ Amyloid Deposits by Biometal Depletion

Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

1996 • 2,543 citations

Copper, iron and zinc in Alzheimer's disease senile plaques

1998 • 2,035 citations

Rapid induction of Alzheimer A beta amyloid formation by zinc

1994 • 1,483 citations

The Aβ Peptide of Alzheimer's Disease Directly Produces Hydrogen Peroxide through Metal Ion Reduction

1999 • 1,070 citations

Dramatic Aggregation of Alzheimer Aβ by Cu(II) Is Induced by Conditions Representing Physiological Acidosis

1998 • 988 citations

Apolipoprotein E allele–specific antioxidant activity and effects on cytotoxicity by oxidative insults and β–amyloid peptides

1996 • 876 citations

Intramuscular desferrioxamine in patients with Alzheimer's disease

1991 • 723 citations

beta-Amyloid-(1-42) is a major component of cerebrovascular amyloid deposits: implications for the pathology of Alzheimer disease.

1993 • 713 citations

Alpha-2 macroglobulin is genetically associated with Alzheimer disease

1998 • 647 citations

Water-soluble Aβ(N-40, N-42) Oligomers in Normal and Alzheimer Disease Brains

1996 • 603 citations

Peptide Compositions of the Cerebrovascular and Senile Plaque Core Amyloid Deposits of Alzheimer′s Disease

1993 • 489 citations

Analysis of Heterogeneous βA4 Peptides in Human Cerebrospinal Fluid and Blood by a Newly Developed Sensitive Western Blot Assay

1996 • 477 citations

Substitutions of hydrophobic amino acids reduce the amyloidogenicity of Alzheimer's disease βA4 peptides

1992 • 406 citations

Alzheimer's β‐amyloid peptide specifically interacts with and is degraded by insulin degrading enzyme

1994 • 385 citations

Zinc-induced Alzheimer's Aβ1–40 Aggregation Is Mediated by Conformational Factors

1997 • 307 citations

The Presence of Amyloid β-Protein in the Detergent-Insoluble Membrane Compartment of Human Neuroblastoma Cells

1998 • 150 citations

alpha2-Macroglobulin as a beta-amyloid peptide-binding plasma protein.

1997 • 131 citations

α₂‐Macroglobulin as a β‐Amyloid Peptide‐Binding Plasma Protein

1997 • 108 citations

Biochemical Evidence for the Long-Tail Form (Aβ1-42/43) of Amyloid β Protein as a Seed Molecule in Cerebral Deposits of Alzheimer′s Disease

1994 • 102 citations

Degradation of Amyloid β-Protein by a Serine Protease-α2-Macroglobulin Complex

1996 • 98 citations

Modified Amyloid β Protein Ending at 42 or 40 with Different Solubility Accumulates in the Brain of Alzheimer′s Disease

1995 • 50 citations

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