Primary Structure of the Cytochrome P450 Lanosterol 14α-Demethylase Gene fromCandida tropicalis

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

A simple method for displaying the hydropathic character of a protein

1982 • 22,471 citations

Rapid and Sensitive Protein Similarity Searches

1985 • 4,091 citations

Codon selection in yeast.

1982 • 1,580 citations

P450 GENES: STRUCTURE, EVOLUTION, AND REGULATION

1987 • 1,559 citations

DNA sequence required for efficient transcription termination in yeast

1982 • 1,014 citations

Mechanisms for the incorporation of proteins in membranes and organelles.

1982 • 875 citations

The P450 Gene Superfamily: Recommended Nomenclature

1987 • 812 citations

A comprehensive sequence analysis program for the IBM personal computer

1984 • 605 citations

Point mutations identify the conserved, intron-contained TACTAAC box as an essential splicing signal sequence in yeast

1984 • 339 citations

Candida tropicalis: A Major Pathogen in Immunocompromised Patients

1979 • 311 citations

Origin of the eukaryotic nucleus determined by rate-invariant analysis of rRNA sequences

1988 • 311 citations

How proteins find mitochondria and intramitochondrial compartments

1986 • 302 citations

CandidaInfections: An Overview

1987 • 298 citations

Role of sterols in membranes

1974 • 260 citations

A short amino-terminal segment of microsomal cytochrome P-450 functions both as an insertion signal and as a stop-transfer sequence.

1987 • 215 citations

Molecular cloning and nucleotide sequence of cDNA for mRNA of mitochondrial cytochrome P-450(SCC) of bovine adrenal cortex.

1984 • 208 citations

Yeast cytochrome P-450 catalyzing lanosterol 14 alpha-demethylation. II. Lanosterol metabolism by purified P-450(14)DM and by intact microsomes.

1984 • 207 citations

Gene Structure of Human Cytochrome P-450(SCC), Cholesterol Desmolase

1987 • 192 citations

Metabolism of Sterols in Yeast

1978 • 187 citations

Primary Structure of the P450 Lanosterol Demethylase Gene fromSaccharomyces cerevisiae

1987 • 178 citations

Sequences responsible for transcription termination on a gene segment in Saccharomyces cerevisiae.

1984 • 154 citations

Mutations in a yeast intron demonstrate the importance of specific conserved nucleotides for the two stages of nuclear mRNA splicing

1986 • 150 citations

Structural Characteristics of Cytochrome P-450. Possible Location of the Heme-Binding Cysteine in Determined Amino-Acid Sequences

1983 • 146 citations

P ‐450 Cytochromes: Structure and Function

1987 • 145 citations

Positive charges at the NH2 terminus convert the membrane-anchor signal peptide of cytochrome P-450 to a secretory signal peptide.

1988 • 135 citations

Interaction of azole derivatives with cytochrome P‐450 isozymes in yeast, fungi, plants and mammalian cells

1987 • 131 citations

Properties of a Yeast Cytochrome P‐450‐Containing Enzyme System which Catalyzes the Hydroxylation of Fatty Acids, Alkanes, and Drugs

1973 • 116 citations

Microbial Models for Drug Metabolism

1979 • 106 citations

Mechanistic studies of lanosterol C-32 demethylation. Conditions which promote oxysterol intermediate accumulation during the demethylation process.

1986 • 97 citations

Isolation of a cytochrome P-450 structural gene from Saccharomyces cerevisiae

1986 • 80 citations

Expression inSaccharomyces cerevisiaeof Chimeric Cytochrome P450 cDNAs Constructed from cDNAs for Rat Cytochrome P450c and P450d

1987 • 58 citations

Isolation of the alkane inducible cytochrome P450 (P450alk) gene from the yeast Candida tropicalis

1987 • 46 citations

Ketoconazole as a Possible Universal Inhibitor of Cytochrome P-450 Dependent Enzymes: Its Mode of Inhibition

1987 • 43 citations

Cytochromes P-450 of yeasts.

1986 • 43 citations

Effect of ketoconazole on cholesterol synthesis and on HMG-COA reductase and LDL-receptor activities in Hep G2 cells

1987 • 42 citations

Characterization of Rabbit Liver Cytochrome P-450 (Laurate ω-1 Hydroxylase) Synthesized in Transformed Yeast Cells1

1988 • 38 citations

The primary structure of a peroxisomal fatty acyl-CoA oxidase from the yeast Candida tropicalis pK233

1987 • 36 citations

Isolation and characterization of an altered cytochrome P-450 from a yeast mutant defective in lanosterol 14 alpha-demethylation.

1987 • 34 citations

A mammalian mutant cell lacking detectable lanosterol 14 alpha-methyl demethylase activity.

1988 • 34 citations

Isolation of the Candida tropicalis gene for P450 lanosterol demethylase and its expression in Saccharomyces cerevisiae

1987 • 33 citations

[14] Use of transposon-promoted deletions in DNA sequence analysis

1987 • 31 citations

Functional characterization of a pyrimidine-rich element in the 5'-noncoding region of the yeast iso-1-cytochrome c gene.

1988 • 29 citations

The nucleotide sequence of complementary DNA and the deduced amino acid sequence of peroxisomal catalase of the yeast Candida tropicalis pK233

1987 • 26 citations

Site-Directed Mutagenesis of Basic Amino Acid Residues in the Extension Peptide of P-450(SCC) Precursor: Effects on the Import of the Precursor into Mitochondria

1987 • 21 citations

Gene Engineering in Yeast for Biodegradation: Immunological Cross-Reactivity Among Cytochrome P-450 System Proteins ofSaccharomyces CerevisiaeandCandida Tropicalis

1985 • 16 citations

The distinction of different types of cytochromes P-450 from the yeasts Candida tropicalis and Saccharomyces uvarum

1986 • 14 citations

[16] A new and simple rapid method for sequencing DNA

1987 • 3 citations