Evidence of Functional Modulation of the MEKK/JNK/cJun Signaling Cascade by the Low Density Lipoprotein Receptor-related Protein (LRP)

Mammalian MAP kinase signalling cascades

2001 • 5,041 citations

LDL-receptor-related proteins in Wnt signal transduction

2000 • 1,305 citations

Reeler/Disabled-like Disruption of Neuronal Migration in Knockout Mice Lacking the VLDL Receptor and ApoE Receptor 2

1999 • 1,231 citations

STRUCTURES AND FUNCTIONS OF MULTILIGAND LIPOPROTEIN RECEPTORS: Macrophage Scavenger Receptors and LDL Receptor-Related Protein (LRP)

1994 • 1,175 citations

An LDL-receptor-related protein mediates Wnt signalling in mice

2000 • 1,080 citations

LDL-receptor-related protein 6 is a receptor for Dickkopf proteins

2001 • 1,028 citations

LRP: a multifunctional scavenger and signaling receptor

2001 • 975 citations

LRP: a multifunctional scavenger and signaling receptor

2001 • 856 citations

A Cytoplasmic Inhibitor of the JNK Signal Transduction Pathway

1997 • 678 citations

Linkage of G Protein-Coupled Receptors to the MAPK Signaling Pathway Through PI 3-Kinase γ

1997 • 671 citations

Neuronal regulation of astroglial morphology and proliferation in vitro.

1985 • 605 citations

Cargo of Kinesin Identified as Jip Scaffolding Proteins and Associated Signaling Molecules

2001 • 593 citations

Interaction of Cytosolic Adaptor Proteins with Neuronal Apolipoprotein E Receptors and the Amyloid Precursor Protein

1998 • 544 citations

Induction of c-fos expression through JNK-mediated TCF/Elk-1 phosphorylation.

1995 • 535 citations

MEKK1/JNK signaling stabilizes and activates p53

1998 • 521 citations

LDL receptor-related protein, a multifunctional ApoE receptor, binds secreted β-amyloid precursor protein and mediates its degradation

1995 • 493 citations

Interactions of the Low Density Lipoprotein Receptor Gene Family with Cytosolic Adaptor and Scaffold Proteins Suggest Diverse Biological Functions in Cellular Communication and Signal Transduction

2000 • 458 citations

The JIP Group of Mitogen-Activated Protein Kinase Scaffold Proteins

1999 • 454 citations

A JNK signal transduction pathway that mediates morphogenesis and an immune response in Drosophila.

1996 • 407 citations

T cell activation by clustered tyrosine kinases

1993 • 379 citations

Low density lipoprotein receptor-related protein mediates apolipoprotein E-dependent neurite outgrowth in a central nervous system-derived neuronal cell line.

1995 • 355 citations

A Novel ε-Cleavage within the Transmembrane Domain of the Alzheimer Amyloid Precursor Protein Demonstrates Homology with Notch Processing

2002 • 349 citations

Stable Expression and Secretion of Apolipoproteins E3 and E4 in Mouse Neuroblastoma Cells Produces Differential Effects on Neurite Outgrowth

1995 • 321 citations

Genetic association of the low-density lipoprotein receptor-related protein gene (LRP), and apolipoprotein E receptor, with late-onset Alzheimer's disease

1997 • 303 citations

Jun NH₂-Terminal Kinase Phosphorylation of p53 on Thr-81 Is Important for p53 Stabilization and Transcriptional Activities in Response to Stress

2001 • 290 citations

Proteolytic Processing of Low Density Lipoprotein Receptor-related Protein Mediates Regulated Release of Its Intracellular Domain

2002 • 286 citations

Role of Tissue Plasminogen Activator Receptor LRP in Hippocampal Long-Term Potentiation

2000 • 285 citations

Platelet-derived Growth Factor (PDGF)-induced Tyrosine Phosphorylation of the Low Density Lipoprotein Receptor-related Protein (LRP)

2002 • 250 citations

The Reelin Receptor ApoER2 Recruits JNK-interacting Proteins-1 and -2

2000 • 245 citations

Requirement of the JIP1 scaffold protein for stress-induced JNK activation

2001 • 230 citations

The LDL Receptor Gene Family

2001 • 230 citations

Apolipoprotein E-containing High Density Lipoprotein Promotes Neurite Outgrowth and Is a Ligand for the Low Density Lipoprotein Receptor-related Protein

1996 • 226 citations

Apolipoprotein E receptors: linking brain development and alzheimer's disease

2000 • 218 citations

Platelet-derived Growth Factor Mediates Tyrosine Phosphorylation of the Cytoplasmic Domain of the Low Density Lipoprotein Receptor-related Protein in Caveolae

2002 • 216 citations

c-Jun N-Terminal Kinase (JNK)-Interacting Protein-1b/Islet-Brain-1 Scaffolds Alzheimer's Amyloid Precursor Protein with JNK

2001 • 188 citations

Neuritic plaque evolution in Alzheimer's disease is accompanied by transition of activated microglia from primed to enlarged to phagocytic forms

1997 • 180 citations

Jun NH2-terminal Kinase (JNK) Interacting Protein 1 (JIP1) Binds the Cytoplasmic Domain of the Alzheimer's β-Amyloid Precursor Protein (APP)

2002 • 163 citations

IB1, a JIP-1-related Nuclear Protein Present in Insulin-secreting Cells

1998 • 141 citations

Demonstration by Fluorescence Resonance Energy Transfer of Two Sites of Interaction between the Low-Density Lipoprotein Receptor-Related Protein and the Amyloid Precursor Protein: Role of the Intracellular Adapter Protein Fe65

2001 • 136 citations

Molecular dissection of ligand binding sites on the low density lipoprotein receptor-related protein.

1994 • 135 citations

Phosphatidylinositol 3-Kinase Mediates Epidermal Growth Factor-Induced Activation of the c-Jun N-Terminal Kinase Signaling Pathway

1997 • 133 citations

Tyrosine-phosphorylated Low Density Lipoprotein Receptor-related Protein 1 (LRP1) Associates with the Adaptor Protein SHC in SRC-transformed Cells

2001 • 124 citations

Protein kinase Cθ, a selective upstream regulator of JNK/SAPK and IL-2 promoter activation in Jurkat T cells

1999 • 113 citations

Fe65 and the protein network centered around the cytosolic domain of the Alzheimer's β‐amyloid precursor protein

1998 • 112 citations

APOE is a major susceptibility gene for Alzheimer's disease

1994 • 102 citations

The p150-Spir protein provides a link between c-Jun N-terminal kinase function and actin reorganization

2000 • 101 citations

The Low‐Density Lipoprotein Receptor‐Related Protein, a Multifunctional Apolipoprotein E Receptor, Modulates Hippocampal Neurite Development

1997 • 92 citations

The Spir actin organizers are involved in vesicle transport processes

2001 • 89 citations

Expression of ?2-macroglobulin receptor/low density lipoprotein receptor-related protein (LRP) in rat microglial cells

2000 • 87 citations

Neuronal Apoptosis by Apolipoprotein E4 through Low-Density Lipoprotein Receptor-Related Protein and Heterotrimeric GTPases

2000 • 83 citations

LDL Induces Transcription Factor Activator Protein-1 in Human Endothelial Cells

1998 • 81 citations

Cellular signalling by lipoprotein receptors

2000 • 73 citations

Shc Regulates Epidermal Growth Factor-induced Activation of the JNK Signaling Pathway

1999 • 68 citations

T cell expressed PKCθ demonstrates cell‐type selective function

2000 • 59 citations

Synergistic action of protein kinase C θ and calcineurin is sufficient for Fas ligand expression and induction of a crmA-sensitive apoptosis pathway in Jurkat T cells

1999 • 52 citations

T cell expressed PKCθ demonstrates cell-type selective function

2000 • 50 citations

T Cell Activation Induced by Novel Gain-of-function Mutants of Syk and ZAP-70

1998 • 43 citations

Activated microglia and cerebral amyloid deposits in alzheimer's disease

1992 • 41 citations

Prolonged Jun N-terminal kinase (JNK) activation and the upregulation of p53 and p21WAF1/CIP1 preceded apoptosis in hepatocytes after partial hepatectomy and cisplatin

2001 • 36 citations

Effects of the amyloid protein precursor of Alzheimer's disease and other ligands of the LDL receptor‐related protein on neurite outgrowth from sympathetic neurons in culture

1998 • 30 citations

Growth Hormone Deficiency Associated with Pituitary Stalk Interruption Syndrome

1998 • 29 citations

Apolipoprotein E Inhibits Serum-stimulated Cell Proliferation and Enhances Serum-independent Cell Proliferation

2001 • 25 citations

Activation of Immune System Effector Function by T-cell or Fc Receptor Intracellular Domains

1992 • 18 citations

Involvement of c-Jun N-terminal kinase and caspase 3-like protease in DNA damage-induced, p53-mediated apoptosis of cultured mouse cerebellar granule neurons

2001 • 16 citations

7,8-Dihydroneopterin induces apoptosis of Jurkat T-lymphocytes via a Bcl-2-sensitive pathway

2002 • 6 citations